Stressed rats fail to exhibit avoidance reactions to innately aversive social calls

Shukla, Ashutosh; Chattarji, Sumantra

doi:10.1038/s41386-021-01230-z

Cited by 8 publications

(15 citation statements)

References 105 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Whereas the former demonstrated increased activity in CeA in avoider animals, the latter showed that acute stress involves an activation of the BLA, while chronic stress enhances activity in the entire amygdala. In contrast, Shukla and Chattarji (2021) showed that chronically stressed animals lack the BLA activation that seems to be required for an appropriate avoidance response in the linear track task. Another brain region that emerges repeatedly is the DRN, the activation of which typically appears to be associated with avoidance (in the ETM or lever press avoidance) (de Andrade et al, 2012Andrade et al, , 2013Hashimoto et al, 2021).…”

Section: Neurobiological Mechanismsmentioning

confidence: 91%

“…The rodent is placed in a small adjustable Plexiglass cylinder with small holes to allow for ventilation. The duration of this stress induction procedure can range from a single acute exposure of 30 min to chronic restraint sessions of 10 h for several weeks ( Gamaro et al, 1999 ; Yamada et al, 2003 ; Nooshinfar et al, 2011 ; de Andrade et al, 2012 ; Radahmadi et al, 2013 ; Navarro-Francés and Arenas, 2014 ; Kozlova et al, 2021 ; Shukla and Chattarji, 2021 ; Wang et al, 2022 ).…”

Section: Methodsmentioning

confidence: 99%

“…After the second playback, the rodent is allowed to explore the track for another 5 min before returning to its home cage. Time spent on the distal half compared to proximal half of the track (relative to the speaker) is compared during habituation and playback ( Shukla and Chattarji, 2021 ).…”

Section: Methodsmentioning

confidence: 99%

“…Finally, in vivo recordings showed that theta waves in BLA and in dmPFC were increased in controls during exposure to the aversive USV calls, but not in stressed rats. The authors stated that the increased BLA-dmPFC synchrony seen in control rats may reflect communication between both areas thereby mediating avoidance responses, 10.3389/fnbeh.2022.983026 which may be impaired in stressed animals (Shukla and Chattarji, 2021).…”

Section: Neurobiological Mechanismsmentioning

confidence: 99%

See 3 more Smart Citations

The effects of stress on avoidance in rodents: An unresolved matter

López-Moraga

Beckers

Luyten

2022

Front. Behav. Neurosci.

View full text Add to dashboard Cite

In the face of a possible threat, a range of physiological (e.g., increased heart rate) and behavioral (e.g., avoidance or escape) responses are recruited. Here, we will focus on avoidance, in its persistent form one of the core symptoms of anxiety disorders and obsessive-compulsive disorder. The initial goal of fear and avoidance responses is to increase survival, but if they become persistent or overgeneralize, they can disrupt normal daily functioning, and ultimately even result in anxiety-related disorders. Relatedly, acute stress responses promote adaptation and survival, while chronic stress has been found to aggravate pathophysiology. Thus, stress might trigger the transition from adaptive to maladaptive responses, e.g., from goal-directed to persistent avoidance. Animal models are prime tools to unravel if and how stress influences avoidance. This is typically done by performing stress inductions prior to the assessment of (passive or active) avoidance behavior. Despite its clinical relevance, the current literature on this topic is fragmented, and an overall conclusion is lacking. In this Review, we first recapitulate the state of the art regarding stress and active as well as passive avoidance procedures. We then summarize the behavioral effects of acute and chronic stress on active and passive avoidance, and discuss the main neurobiological findings of the field. Finally, we highlight possible reasons for the largely contradictory findings in the literature and we propose strategies to further unravel the effect of stress on avoidance behavior. A deeper understanding of this currently unresolved matter may provide further insights in the etiology and treatment of anxiety-related disorders.

show abstract

Section: Neurobiological Mechanismsmentioning

confidence: 91%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Neurobiological Mechanismsmentioning

confidence: 99%

See 2 more Smart Citations

The effects of stress on avoidance in rodents: An unresolved matter

López-Moraga

Beckers

Luyten

2022

Front. Behav. Neurosci.

View full text Add to dashboard Cite

show abstract

“…Would these effects on astrocytes, if any, also vary between the hippocampus and amygdala? Here we address these questions by combining morphometric analyses of spine-density in principal neurons, as well as astrocyte structure, in the basal amygdala (BA) and hippocampal area CA1 using a well-characterized rat model of chronic immobilization stress ( Ghosh et al, 2013 ; Mitra et al, 2005 ; Rahman et al, 2016 ; Shukla and Chattarji, 2021 ; Suvrathan et al, 2014 ; Vyas et al, 2002 ).…”

Section: Introductionmentioning

confidence: 99%

Riluzole prevents stress-induced spine plasticity in the hippocampus but mimics it in the amygdala

Naskar

Datta

Chattarji

2022

Neurobiology of Stress

Self Cite

View full text Add to dashboard Cite

The paradoxical effects of chronic stress on avoidance: a role for amygdala-dorsomedial prefrontal cortex dialogue

Grunfeld

Likhtik

2022

Neuropsychopharmacol.

View full text Add to dashboard Cite

Chronic stress has been a pervasive factor during the new-normal of the COVID era. Notably, although moderate stress is critical for adaptation in a changing world, prolonged stress exposure can lead to an array of mental health conditions, often associated with structural changes in brain regions that affect emotional learning, such as the amygdala, the frontal cortices, and the hippocampus. To better target treatments, it is critical that we improve our understanding of the physiological and behavioral consequences of increased exposure to chronic stress. To this end, rodent behavioral tasks have been instrumental for probing symptoms of stressinduced behavioral change, including the social interaction test, the sucrose preference test, and the forced swim test to study increased social avoidance, anhedonia, and decreased motivation, respectively.

show abstract

Stressed rats fail to exhibit avoidance reactions to innately aversive social calls

Cited by 8 publications

References 105 publications

The effects of stress on avoidance in rodents: An unresolved matter

The effects of stress on avoidance in rodents: An unresolved matter

Riluzole prevents stress-induced spine plasticity in the hippocampus but mimics it in the amygdala

The paradoxical effects of chronic stress on avoidance: a role for amygdala-dorsomedial prefrontal cortex dialogue

Contact Info

Product

Resources

About