Stressful environmental stimuli increase extracellular DOPAC levels in the prefrontal cortex of hypoemotional (Roman high-avoidance) but not hyperemotional (Roman low-avoidance) rats. An in vivo voltammetric study

D'Angio, Magali; Serrano, A.; Driscoll, Peter; Scatton, B.

doi:10.1016/0006-8993(88)90768-8

Cited by 133 publications

(41 citation statements)

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“…A possible interpretation of this is that the septohippocampal system is involved in finding the appropriate coping reaction in an aversive situation (see also the theory by Gray [19]). According to D'Angio et al [9] also the medial prefrontal cortex plays a role in finding the appropriate coping strategy by way of influencing "attentional and/or cognitive processes in an attempt to deal with the stressor". The results of the present study, however, indicate that this is not true for the prelimbic area (it may well be true for the anterior cingulate area), because coping behavior was not influenced by the lesion.…”

Section: Discussionmentioning

confidence: 99%

“…According to another view [31] it may have the function '*to update appropriate response outputs dependent on ..[the] internal state", which may among others be determined by the amygdala, which determines the 'emotional significance' of stimuli. Related to this is the opinion that the medial prefrontal cortex plays a role in stress responses [4], namely in finding appropriate coping reactions [9]. Besides these hypotheses, there are also those assigning to the prelimbic area a function in selecting responses in a working memory task context [18] or selecting 'cognitive strategies' [5].…”

Section: Introductionmentioning

confidence: 99%

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Effects of an electrolytic lesion of the prelimbic area on anxiety-related and cognitive tasks in the rat

Maaswinkel

Gispen

Spruijt

1996

Behavioural Brain Research

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The aim of this paper was to study the role of the prelimbic area of rats in response selection• A bilateral electrolytic lesion was made in the prelimbic area. The rats were tested in the Morris water-maze, the conditioned shock-prod burying test, the elevated plus-maze, a modified open field test, and the step-through passive avoidance test. In the water-maze during initial acquisition, the latency times of the lesioned rats were not different from those of the controls, but they found the platform faster than the shamoperated rats after the platform was placed in a new position. The lesion did not affect performance in the shock-prod burying test. In the elevated plus-maze the lesioned rats were more active than the sham-operated rats and spent more time on the open arms. In the open field there was no difference between lesioned and sham-operated rats with regard to distance travelled or the time spent near the object in the center of the open field. In the passive avoidance test the lesioned rats had a shorter latency time to enter the shock compartment during the retention trial than the sham-operated rats did. The results were discussed in relation to those of similar studies. The extent and precise localisation of the lesion seems to be crucial for the outcome: lesions confined to the prelimbic area may have the opposite effects of larger lesions. Furthermore, it may well be that the prelimbic area is only involved in processing of stimuli of a specific sensory modality, as made probable by the results of different conditioned reinforcement tasks. Finally, it was stated that we still lack a hypothesis about the precise role of the prelimbic area in response selections.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of an electrolytic lesion of the prelimbic area on anxiety-related and cognitive tasks in the rat

Maaswinkel

Gispen

Spruijt

1996

Behavioural Brain Research

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“…Thus, it has been hypothesized that long-term exposure to drugs of abuse may alter the functional activity of dopaminergic afferent projections and glutamatergic neurons in frontocortical areas, with a consequent deficiency in the ability to inhibit inappropriate responses to drugs or drug-paired stimuli (Jentsch and Taylor, 1999;Everitt and Wolf, 2002;Chambers et al, 2003;Vanderschuren and Everitt, 2005). It is therefore noteworthy in this context that, compared with RLA rats, the mesocortical dopaminergic system of RHA rats is more robustly activated by both stressful and rewarding stimuli (D'Angio et al, 1988;Corda et al, 1997;Giorgi et al, 1999Giorgi et al, , 2003. In addition, RHA rats display higher scores than RLA rats in experimental paradigms used to assess sensation/ novelty seeking behavior in rodents (Siegel et al, 1993;Escorihuela et al, 1999;Fernández-Teruel et al, 2002;Steimer and Driscoll 2005).…”

Section: Figurementioning

confidence: 99%

“…Thus, compared with their RLA counterparts, RHA rats display a more robust sensation/novelty seeking profile, as well as higher baseline levels of impulsivity, and a marked preference for and intake of natural and drug rewards (Zeier et al, 1978;Siegel et al 1993;Escorihuela et al 1999;Giorgi et al 1999;Fernández-Teruel et al 2002). The phenotypic traits that distinguish these lines are at least partly determined by differences in the functional properties of their central dopaminergic pathways: (1) stressors and anxiogenic drugs activate the mesocortical dopaminergic projection of RHA, but not RLA, rats (D'Angio et al, 1988;Corda et al, 1997;Giorgi et al, 2003); (2) RHA rats have a higher density of D-1 dopamine (DA) receptors in the NAc (Giorgi et al, 1994); (3) the acute administration of psychostimulants and morphine causes a larger increment in motor activity and in DA output in the shell than in the core of the NAc of RHA, but not RLA, rats (Lecca et al, 2004); (4) the repeated administration of psychostimulants and morphine induces behavioral sensitization only in RHA rats Corda et al, 2005;Giorgi et al, 2005a); (5) in sensitized RHA rats, a subsequent challenge with these drugs elicits a more robust increment in DA output in the NAc-core, associated with an attenuated dopaminergic response in the NAc-shell, whereas these adaptive changes are not observed in sensitization-resistant RLA rats (Giorgi et al, 2005b(Giorgi et al, , 2007.…”

Section: Introductionmentioning

confidence: 99%

The Roman High- and Low-Avoidance Rat Lines Differ in the Acquisition, Maintenance, Extinction, and Reinstatement of Intravenous Cocaine Self-Administration

Fattore

Piras

Corda

et al. 2008

Neuropsychopharmacol

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The selective breeding of Roman high-(RHA) and low-avoidance (RLA) rats for, respectively, rapid vs extremely poor acquisition of avoidant behavior in a shuttlebox has produced two phenotypes that differ in temperament traits, in mesocortical/mesolimbic dopamine system function, and in the behavioral and neurochemical responses to the acute and repeated administration of psychostimulants and opiates. The phenotypic traits of the RHA line predict higher susceptibility, compared with RLA rats, to the reinforcing properties of addictive substances like cocaine. The present study was designed to compare the acquisition, maintenance, reinstatement of drugseeking after long-term extinction, and reacquisition of intravenous cocaine self-administration (SA) behavior in the Roman lines. Compared with RLA rats, the rates of responding during cocaine SA acquisition were higher, extinction from cocaine SA was prolonged, and drug-induced reinstatement of cocaine-seeking behavior was more robust in RHA rats. Moreover, only RHA rats reacquired extinguished lever-pressing activity when a low reinforcing dose of cocaine was available. These findings are consistent with the view that subjects with genetically determined high responsiveness to the acute and chronic (ie, sensitizing) effects of psychostimulants, such as RHA rats, also display a higher propensity to self -administer cocaine. Further comparative studies in the Roman lines, using SA paradigms that distinguish mere drug-taking from the compulsive and uncontrolled drug use that characterizes addiction in humans, may eventually help to characterize the relationships among genotype, temperament traits, and neurobiological mechanisms involved in the individual vulnerability to cocaine addiction.

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“…These findings suggest that RLA rats represent a valid genetic model to investigate the neural circuitry and molecular mechanisms underlying stress‐induced depression and, more specifically, to study depression associated with anxiety symptoms. Multidisciplinary studies aimed at identifying the central neuronal circuits involved in the above‐mentioned behavioral differences across the Roman lines have shown that their divergent phenotypic traits may be accounted for, at least in part, by differences in the functional responses of their central monoaminergic systems (D'Angiò, Serrano, Driscoll, & Scatton, 1988; Giorgi, Lecca, Piras, Driscoll, & Corda, 2003; Giorgi, Piras, Lecca, & Corda, 2005; Giorgi et al., 1994; Giorgi, Piras, et al., 2003 Giorgi et al., 2007, 2015; Lecca, Piras, Driscoll, Giorgi, & Corda, 2004; Sanna et al., 2015; Tournier et al., 2013). …”

Section: Introductionmentioning

confidence: 99%

Expression of BDNF and trkB in the hippocampus of a rat genetic model of vulnerability (Roman low‐avoidance) and resistance (Roman high‐avoidance) to stress‐induced depression

et al. 2017

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IntroductionThe selective breeding of Roman High‐ (RHA) and Low‐Avoidance (RLA) rats for, respectively, rapid versus poor acquisition of the active avoidance response has generated two distinct phenotypes differing in many behavioral traits, including coping strategies to aversive conditions. Thus, RLA rats are considered as a genetic model of vulnerability to stress‐induced depression whereas RHA rats are a model of resilience to that trait. Besides the monoamine hypothesis of depression, there is evidence that alterations in neuronal plasticity in the hippocampus and other brain areas are critically involved in the pathophysiology of mood disorders.Materials and MethodsWestern blot (WB) and immunohistochemistry were used to investigate the basal immunochemical occurrence of brain‐derived neurotrophic factor (BDNF) and its high‐affinity tyrosine‐kinase receptor trkB in the dorsal and ventral hippocampus of adult RHA and RLA rats.Results WB analysis indicated that the optical density of BDNF‐ and trkB‐positive bands in the dorsal hippocampus is, respectively, 48% and 25% lower in RLA versus RHA rats. Densitometric analysis of BDNF‐ and trkB‐like immunoreactivity (LI) in brain sections showed that BDNF‐LI is 24% to 34% lower in the different sectors of the Ammon's horn of RLA versus RHA rats, whereas line‐related differences are observed in the dentate gyrus (DG) only in the ventral hippocampus. As for trkB‐LI, significant differences are observed only in the dorsal hippocampus, where density is 23% lower in the DG of RLA versus RHA rats, while no differences across lines occur in the Ammon's horn.ConclusionThese findings support the hypothesis that a reduced BDNF/trkB signaling in the hippocampus of RLA versus RHA rats may contribute to their more pronounced vulnerability to stress‐induced depression.

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Stressful environmental stimuli increase extracellular DOPAC levels in the prefrontal cortex of hypoemotional (Roman high-avoidance) but not hyperemotional (Roman low-avoidance) rats. An in vivo voltammetric study

Cited by 133 publications

References 42 publications

Effects of an electrolytic lesion of the prelimbic area on anxiety-related and cognitive tasks in the rat

Effects of an electrolytic lesion of the prelimbic area on anxiety-related and cognitive tasks in the rat

The Roman High- and Low-Avoidance Rat Lines Differ in the Acquisition, Maintenance, Extinction, and Reinstatement of Intravenous Cocaine Self-Administration

Expression of BDNF and trkB in the hippocampus of a rat genetic model of vulnerability (Roman low‐avoidance) and resistance (Roman high‐avoidance) to stress‐induced depression

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