Stressful experiences differentially regulate immediate-early genes and stress hormone receptors in immature and mature dentate gyrus neurons

Todorova, Evgenia V; Cahill, Shaina P.; Snyder, Jason S.

doi:10.19185/matters.201710000009

Cited by 1 publication

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References 42 publications

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“…Also, we found that cells analysed three weeks post-IdU labelling show decreased activation in mice exposed to forced-swim stress and similar results were recently reported with restrained stress that reduces levels of zif268, another IEG, in immature neurons but not in mature neurons. The newborn cells analysed in that study may correspond to cells ranging between 18 and 30 days postcumulative BrdU labelling [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

Newly Generated Cells in the Dentate Gyrus Differentially Respond to Brief Spatial Exploration and Forced Swim in Adult Female Balb/C Mice

2018

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Neurogenesis in the hippocampus is influenced by several factors including external stimuli. In addition to their involvement in learning and memory processes, newborn neurons of the dentate gyrus (DG) buffer against the effects of stress. Although the response of these cells to environmental stimuli has been shown, the age of the cells that respond to a brief spatial exploration or a stressful situation produced by forced-swim stress in adult female Balb/C mice is still unknown. Here, we investigated the activation of newborn neurons after three (IdU) or six weeks (CldU) postlabelling with the expression of Arc in the same mice but exposed to different environmental stimuli. Mice housed in standard conditions showed an increase in the activation of CldU-labelled cells after two exposures to a brief spatial exploration but no increase in the activation of IdU-labelled cells compared with the control group. Additionally, we analysed neuronal activation in the DG of mice housed in standard conditions and further exposed to forced-swim stress. We found a decreased activation of IdU-labelled cells in mice exposed to forced-swim stress with increase number of CldU-labelled cells. Our results suggest that based on their time postlabelling, newly generated hippocampal neurons show a different response to several environmental stimuli.

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Section: Discussionmentioning

confidence: 99%