Stressing the potential of guanfacine as a treatment for cocaine use disorder

Lustberg, Daniel

doi:10.1038/s41386-020-0649-4

Cited by 1 publication

(1 citation statement)

References 10 publications

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“…Although not FDA-approved for ADHD in adults, guanfacine extended-release has also been shown to reduce cocaine and alcohol craving in cocaine-dependent women ( Fox et al, 2014 ), and there has been a growing interest in its application to cocaine addiction ( Lustberg & Weinshenker, 2020 ; Milivojevic et al, 2017 ). Similarly, the novel nonstimulant viloxazine extended-release, currently approved to treat ADHD in children (≥6 years) and adults, has not demonstrated any potential for abuse in non-human primate models using the original, instant-release formulation ( Yanagita et al, 1980 ).…”

Section: Impact Of Pharmacological Treatmentmentioning

confidence: 99%

Functional Impairments Associated With ADHD in Adulthood and the Impact of Pharmacological Treatment

et al. 2023

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Objective: Among untreated adults, functional impairments associated with ADHD are widespread and cumulative, and can include social, educational, and professional impairments, increased risk of accidents and mortality, and reduced quality of life. Here, we review the most prominent functional impairments in adults with ADHD and summarize evidence describing the potential role of medication in improving outcomes. Method: Articles related to the search terms “ADHD,” “adult,” and functional impairments were identified through Google Scholar and PubMed and selected for inclusion based on four criteria: strength of evidence, relevance to current challenges in adult ADHD, impact on the field, and recency of the results. Results: We identified 179 papers to support the conclusions on the relationship between ADHD and functional impairments, and the impact of pharmacological therapy on functional impairments. Conclusion: This narrative review provides evidence that pharmacological treatment can be effective in minimizing not only the symptoms of ADHD, but its functional consequences as well.

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