2024
DOI: 10.1021/acs.analchem.4c05008
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Stressor-Actuated Proximity Labeling for Reporting Cellular Interaction

Guyu Wang,
Yichun Wang,
Lan Wang
et al.

Abstract: Cell-cell interactions determine the activation state and function of cells. When host cells are exposed to stressors such as microorganisms, immune defense machinery is activated to release H 2 O 2 , providing direct evidence of the relevant cellular physiological processes. Inspired by the fact that peroxidase can catalyze proximity labeling in the presence of exogenous H 2 O 2 , a stressor-actuated proximity labeling (SAPL) strategy is developed to report the process information on cell−cell interactions by… Show more

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