Stressor-specific induction of heat shock proteins in rat hepatoma cells

Wiegant, F. A. C.; Souren, J. E. M.; Rijn, J. van; Wijk, R. Van

doi:10.1016/0300-483x(94)90034-5

Cited by 48 publications

(35 citation statements)

References 31 publications

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“…However, little is known about the cause/effect relationship between the cadmium-induced response and the mitochondrial chaperonine (hsp60) expression. Some authors have demonstrated the hsp60 induction in response to cadmium in hepatoma cells [29]; in addition, others have proposed hsp60 as a potential biomarker to toxicant stress in nematode [9]. We have previously shown that P. lividus embryos subjected to heat shock increased the synthesis levels of hsp56, a mitochondrial chaperonine belonging to the hsp60 family [25,30].…”

Section: Discussionmentioning

confidence: 93%

Cadmium induces the expression of specific stress proteins in sea urchin embryos

Roccheri

Agnello

Bonaventura

et al. 2004

Biochemical and Biophysical Research Communications

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Section: Discussionmentioning

confidence: 93%

Cadmium induces the expression of specific stress proteins in sea urchin embryos

Roccheri

Agnello

Bonaventura

et al. 2004

Biochemical and Biophysical Research Communications

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“…Clone VL21 corresponds to a mRNA that encodes the C. elegans HSP70F protein precursor. The expression of HSP70 has been shown to increase following cadmium exposure in mammalian cells (16,55). This response, however, has not been reported in C. elegans.…”

Section: Effect Of Cadmium On Gene Expression-the Level Of the Cmentioning

confidence: 91%

“…Cadmium has been shown to activate the transcription of the C. elegans hsp-16 gene, which encodes for a low molecular weight HSP (62). In cultured cells, cadmium increases HSP70 protein and mRNA levels, as well as the levels of HSP28, -60, -68, -84, -90, and -100 (16,55,63). It also causes an increase in the binding of the heat shock transcription factor to HSP70 promoter (64).…”

Section: Figmentioning

confidence: 99%

“…These proteins (a) chelate the metal to prevent further damage, (b) remove reactive oxygen species, (c) repair membrane and DNA damage, and (d) renature or degrade unfolded proteins. Cadmium has been shown to affect the steady-state levels of the mRNAs encoding metallothionein (13), heme oxygenase (14), ␥-glutamylcysteine synthetase (15), low and high molecular weight heat shock proteins (16), and ubiquitin (17). In addition, increases in superoxide dismutase, catalase, glutathione peroxidase, and glucose-6-phosphate dehydrogenase activities are observed following cadmium exposure in cultured cells and whole animals (18,19).…”

mentioning

confidence: 99%

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Cadmium-regulated Genes from the NematodeCaenorhabditis elegans

Liao¹,

Freedman²

1998

Journal of Biological Chemistry

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The transition metal cadmium is a pervasive and persistent environmental contaminant that has been shown to be both a human toxicant and carcinogen. To inhibit cadmium-induced damage, cells respond by increasing the expression of genes encoding stress-response proteins. In most cases, the mechanism by which cadmium affects the expression of these genes remains unknown. It has been demonstrated in several instances that cadmium activates gene transcription through signal transduction pathways, mediated by protein kinase C, cAMPdependent protein kinase, or calmodulin. A codicil is that cadmium should influence the expression of numerous genes. To investigate the ability of cadmium to affect gene transcription, the differential display technique was used to analyze gene expression in the nematode Caenorhabditis elegans. Forty-nine cDNAs whose steady-state levels of expression change 2-6-fold in response to cadmium exposure were identified. The nucleotide sequences of the majority of the differentially expressed cDNAs are identical to those of C. elegans cosmids, yeast artificial chromosomes, expressed sequence tags, or predicted genes. The translated amino acid sequences of several clones are identical to C. elegans metallothionein-1, HSP70, collagens, and rRNAs. In addition, C. elegans homologues of pyruvate carboxylase, DNA gyrase, ␤-adrenergic receptor kinase, and human hypothetical protein KIAA0174 were identified. The translated amino acid sequences of the remaining differentially expressed cDNAs encode novel proteins.

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“…It means that stimulation of the (disease) pattern by another irritation that has a similar pattern is able to extinguish the diseased state in cells and increases the number of surviving cells. 54,55 Subsequently, research by Jonas and colleagues demonstrated that specific protective proteins and their mRNA precursors are stimulated by specific dilutions of toxins. 56 This finding bridges the gap somewhat between the simile principle and potential biologic mechanisms but does not address the question of ultra-high dilutions.…”

Section: Homeopathy Research 815mentioning

confidence: 99%

Research on Homeopathy: State of the Art

Walach

Jonas²,

Ives³

et al. 2005

The Journal of Alternative and Complementary Medicine

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In this paper, we review research on homeopathy from four perspectives, focusing on reviews and some landmark studies. These perspectives are laboratory studies, clinical trials, observational studies, and theoretical work. In laboratory models, numerous effects and anomalies have been reported. However, no single model has been sufficiently widely replicated. Instead, researchers have focused on ever-new models and experiments, leaving the picture of scattered anomalies without coherence. Basic research, trying to elucidate a purported difference between homeopathic remedies and control solutions has also produced some encouraging results, but again, series of independent replications are missing. While there are nearly 200 reports on clinical trials, few series have been conducted for single conditions. Some of these series document clinically useful effects and differences against placebo and some series do not. Observational research into uncontrolled homeopathic practice documents consistently strong therapeutic effects and sustained satisfaction in patients. We suggest that this scattered picture has to do with the fourth line of research: lack of a good theory. Some of the extant theoretical models are reviewed, including placebo, water structure, silica contamination, energy models, and entanglement models. It emerges that local models, suggesting some change in structure in the solvent, are far from convincing. The nonlocal models proposed would predict that it is impossible to nail down homeopathic effects with direct experimental testing and this places homeopathy in a scientific dilemma. We close with some suggestions for potentially fruitful research.

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Stressor-specific induction of heat shock proteins in rat hepatoma cells

Cited by 48 publications

References 31 publications

Cadmium induces the expression of specific stress proteins in sea urchin embryos

Cadmium induces the expression of specific stress proteins in sea urchin embryos

Cadmium-regulated Genes from the NematodeCaenorhabditis elegans

Research on Homeopathy: State of the Art

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