Stretch-induced nerve conduction deficits in guinea pig ex vivo nerve

Li, Jianming; Shi, Riyi

doi:10.1016/j.jbiomech.2006.02.009

Cited by 42 publications

(41 citation statements)

References 38 publications

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“…Picture courtesy of Jon Block, DC, CNIM. recordings from distal muscles as well as the contralateral (nonsurgical-side) quadriceps MEP response amplitude should theoretically remain unchanged (Figures 2A and 2B). There have been multiple animal studies where peripheral nerve conduction is recorded while stretch or compressive forces are applied to a peripheral nerve segment (Kieman and Kaji, 2013, Li and Shi 2007, Ochs et al 2000. It has been demonstrated that with increasing forces applied over time, at some point, nerve conduction ceases and impulses are no longer conducted across the stretched or compressed segment (conduction block).…”

Section: Theory For the Utility Of Meps For Llifs And Rationale For mentioning

confidence: 99%

“…(L: left, VM: vastus medialis, VL: vastus lateralis, EDB: extensor digitorum brevis, AFIL: abductor hallicus longus, ADD: adductors, RF: rectus femoris, ABS: abdominals). Picture courtesy of Justin Silverstein, DHSc, CNIM. nerves can lead to irreversible damage (Kieman and Kaji, 2013, Li and Shi, 2007, Ochs et al 2000.…”

Section: Theory For the Utility Of Meps For Llifs And Rationale For mentioning

confidence: 99%

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Motor Evoked Potentials for Femoral Nerve Protection in Transpsoas Lateral Access Surgery of the Spine

Block¹,

Silverstein

Ball³

et al. 2015

The Neurodiagnostic Journal

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Detecting potential intraoperative injuries to the femoral nerve should be the main goal of neuromonitoring of lateral lumber interbody fusion (LLIF) procedures. We propose a theory and technique to utilize motor evoked potentials (MEPs) to protect the femoral nerve (a peripheral nerve), which is at risk in LLIF procedures. MEPs have been advocated and widely used for monitoring spinal cord function during surgical correction of spinal deformity and surgery of the cervical and thoracic spine, but have had limited acceptance for use in lumbar procedures. This is due to the theoretical possibility that MEP recordings may not be sensitive in detecting an injury to a single nerve root considering there is overlapping muscle innervation of adjacent root levels. However, in LLIF procedures, the surgeon is more likely to encounter lumbar plexus elements than nerve roots. Within the substance of the psoas muscle, the L2, L3, and L4 nerve roots combine in the lumbar plexus to form the trunk of the femoral nerve. At the point where the nerve roots become the trunk of the femoral nerve, there is no longer any alternative overlapping innervation to the quadriceps muscles. Insult to the fully formed femoral nerve, which completely blocks conduction in motor axons, should theoretically abolish all MEP responses to the quadriceps muscles. On multiple occasions over the past year, our neuro-monitoring groups have observed significantly degraded amplitudes of the femoral motor and/or sensory evoked potentials limited to only the surgical side. Most of these degraded response amplitudes rapidly returned to baseline values with a surgical intervention (i.e., prompt removal of surgical retraction).

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Section: Theory For the Utility Of Meps For Llifs And Rationale For mentioning

confidence: 99%

Section: Theory For the Utility Of Meps For Llifs And Rationale For mentioning

confidence: 99%

Motor Evoked Potentials for Femoral Nerve Protection in Transpsoas Lateral Access Surgery of the Spine

Block¹,

Silverstein

Ball³

et al. 2015

The Neurodiagnostic Journal

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“…The compound nerve action potential has been recorded in many different species, including cats[2627], rats[5], guinea pig[2829], monkeys[30] and humans[23]. A similar compound nerve action potential waveform is recorded in vitro [31] or in vivo [32].…”

Section: Introductionmentioning

confidence: 99%

The optimal distance between two electrode tips during recording of compound nerve action potentials in the rat median nerve

Lao

Zhao

et al. 2014

Neural Regen Res

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The distance between the two electrode tips can greatly influence the parameters used for recording compound nerve action potentials. To investigate the optimal parameters for these recordings in the rat median nerve, we dissociated the nerve using different methods and compound nerve action potentials were orthodromically or antidromically recorded with different electrode spacings. Compound nerve action potentials could be consistently recorded using a method in which the middle part of the median nerve was intact, with both ends dissociated from the surrounding fascia and a ground wire inserted into the muscle close to the intact part. When the distance between two stimulating electrode tips was increased, the threshold and supramaximal stimulating intensity of compound nerve action potentials were gradually decreased, but the amplitude was not changed significantly. When the distance between two recording electrode tips was increased, the amplitude was gradually increased, but the threshold and supramaximal stimulating intensity exhibited no significant change. Different distances between recording and stimulating sites did not produce significant effects on the aforementioned parameters. A distance of 5 mm between recording and stimulating electrodes and a distance of 10 mm between recording and stimulating sites were found to be optimal for compound nerve action potential recording in the rat median nerve. In addition, the orthodromic compound action potential, with a biphasic waveform that was more stable and displayed less interference (however also required a higher threshold and higher supramaximal stimulus), was found to be superior to the antidromic compound action potential.

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“…Another group reports that the extant data indicate that strain of 6 -8% for short duration causes transient physiological changes that appear to be within the normal stress tolerance of the tissue, whereas acute strains of 11% or greater cause long-term damage and may be considered to be excessive stress states (35). A study of guinea pig tibial nerves in 2007 included the application of incremental quantities of stretch and measuring corresponding changes in compound action potential (CAP) (21). Results of this study showed that a longitudinal strain of 5% caused a 16% reduction in the CAP, a strain of 10% caused a 50% reduction in the CAP, and with 20% strain, severe conduction block with minimal recovery was observed (21).…”

mentioning

confidence: 99%

“…A study of guinea pig tibial nerves in 2007 included the application of incremental quantities of stretch and measuring corresponding changes in compound action potential (CAP) (21). Results of this study showed that a longitudinal strain of 5% caused a 16% reduction in the CAP, a strain of 10% caused a 50% reduction in the CAP, and with 20% strain, severe conduction block with minimal recovery was observed (21). Given the differences in the species and types of nerves described above, the comparison of quantitative data among studies is challenging.…”

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confidence: 99%

A computational study of the role of the aortic arch in idiopathic unilateral vocal-fold paralysis

Williams

Ayylasomayajula

Behkam

et al. 2015

Journal of Applied Physiology

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Unilateral vocal-fold paralysis (UVP) occurs when one of the vocal folds becomes paralyzed due to damage to the recurrent laryngeal nerve (RLN). Individuals with UVP experience problems with speaking, swallowing, and breathing. Nearly two-thirds of all cases of UVP is associated with impaired function of the left RLN, which branches from the vagus nerve within the thoracic cavity and loops around the aorta before ascending to the larynx within the neck. We hypothesize that this path predisposes the left RLN to a supraphysiological, biomechanical environment, contributing to onset of UVP. Specifically, this research focuses on the identification of the contribution of the aorta to onset of left-sided UVP. Important to this goal is determining the relative influence of the material properties of the RLN and the aorta in controlling the biomechanical environment of the RLN. Finite element analysis was used to estimate the stress and strain imposed on the left RLN as a function of the material properties and loading conditions. The peak stress and strain in the RLN were quantified as a function of RLN and aortic material properties and aortic blood pressure using Spearman rank correlation coefficients. The material properties of the aortic arch showed the strongest correlation with peak stress [ρ = -0.63, 95% confidence interval (CI), -1.00 to -0.25] and strain (ρ = -0.62, 95% CI, -0.99 to -0.24) in the RLN. Our results suggest an important role for the aorta in controlling the biomechanical environment of the RLN and potentially in the onset of left-sided UVP that is idiopathic.

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Stretch-induced nerve conduction deficits in guinea pig ex vivo nerve

Cited by 42 publications

References 38 publications

Motor Evoked Potentials for Femoral Nerve Protection in Transpsoas Lateral Access Surgery of the Spine

Motor Evoked Potentials for Femoral Nerve Protection in Transpsoas Lateral Access Surgery of the Spine

The optimal distance between two electrode tips during recording of compound nerve action potentials in the rat median nerve

A computational study of the role of the aortic arch in idiopathic unilateral vocal-fold paralysis

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