Stretchable ultrasonic arrays for the three-dimensional mapping of the modulus of deep tissue

Hu, Hongjie; Ma, Yuxiang; Gao, Xiaoxiang; Song, Dawei; Li, Mohan; Huang, Hao; Qian, Xuejun; Wu, Ray S.; Shi, Keren; Ding, Hong; Lin, Muyang; Chen, Xiangjun; Zhao, Wenbo; Qi, Baiyan; Zhou, Sai; Chen, Ruimin; Gu, Yue; Chen, Yimu; Lei, Yusheng; Wang, Chonghe; Wang, Chunfeng; Tong, Yitian; Cui, Haotian; Abdal, Abdulhameed; Zhu, Yangzhi; Tian, Xinyu; Chen, Zhaoxin; Lu, Chengchangfeng; Yang, Xinqi; Mu, Jing; Lou, Zhiyuan; Eghtedari, Mohammad; Zhou, Qifa; Oberai, Assad A.; Xu, Sheng

doi:10.1038/s41551-023-01038-w

Cited by 48 publications

(18 citation statements)

References 86 publications

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“…Emerging applications, key properties, and examples of (a) bioadhesive electronics; − (b) bioadhesive chemical sensors; − (c) bioadhesive drug delivery devices; , (d) bioadhesive cell depots; (e) bioadhesive photonic devices; − (f) bioadhesive acoustic devices; − (g) bioadhesive mechanomodulation; and (h) bioadhesive thermal stimulators . Images reproduced with permission from ref (Copyright 2011 AAAS), ref (Copyright 2016 American Chemical Society), ref (Copyright 2022 Elsevier), ref (Copyright 2022 American Chemical Society), ref (Copyright 2016 AAAS), ref (Copyright 2021 Springer Nature), ref (Copyright 2021 Elsevier), ref (Copyright 2018 Wiley), ref (Copyright 2020 Wiley), ref (Copyright 2021 Wiley), ref (Copyright 2014 Elsevier), ref (Copyright 2013 Springer Nature), ref (Copyright 2019 Springer Nature), ref (licensed under CC BY 4.0), ref (Copyright 2022 AAAS), ref (Copyright 2023 Springer Nature), ref (Copyright 2023 Springer Nature), ref (Copyright 2022 Springer Nature), and ref (Copyright 2022 AAAS).…”

Section: Nontraditional Applications Of Bioadhesivesmentioning

confidence: 99%

“…Recently, wearable ultrasound devices have attracted substantial interest for their potential to unlock continuous deep-tissue imaging and ultrasound-based stimulation (Figure f). The noninvasive, radiation-free characteristics of ultrasound imaging have made it a valuable tool for assessing diverse body functions, including muscular activity, cardiac function, blood flow, bone healing, and gastric activity (refs − , , − ). Traditional ultrasound components are rigid and bulky, posing a challenge to their on-body integration.…”

Section: Nontraditional Applications Of Bioadhesivesmentioning

confidence: 99%

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Bioadhesive Technology Platforms

Wu,

Zhao

2023

Chem. Rev.

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Bioadhesives have emerged as transformative and versatile tools in healthcare, offering the ability to attach tissues with ease and minimal damage. These materials present numerous opportunities for tissue repair and biomedical device integration, creating a broad landscape of applications that have captivated clinical and scientific interest alike. However, fully unlocking their potential requires multifaceted design strategies involving optimal adhesion, suitable biological interactions, and efficient signal communication. In this Review, we delve into these pivotal aspects of bioadhesive design, highlight the latest advances in their biomedical applications, and identify potential opportunities that lie ahead for bioadhesives as multifunctional technology platforms.

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Section: Nontraditional Applications Of Bioadhesivesmentioning

confidence: 99%

Section: Nontraditional Applications Of Bioadhesivesmentioning

confidence: 99%

Bioadhesive Technology Platforms

Wu,

Zhao

2023

Chem. Rev.

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“…Over the past two decades, advances in stretchable electronics have drastically transformed the landscape of today’s functional devices and led to the current prosperities of the field of flexible and stretchable electronics. Owing to their outstanding deformability, flexible and stretchable electronics have found numerous practical applications, spanning many different aspects of daily life and industry, such as long-term healthcare, − diagnosis and therapeutics, , sports protection − and athletic analysis, − nondestructive testing of large equipment, robotics, − cosmetics, , Internet of things, , among others. Commercialization of flexible/stretchable electronics is also under way, represented by a series of startups, such as MC10 (Medidata), iRhythm, VitalConnect, Chero, LifeSignals, BioIntelliSense, Sibel Health, c3nano, and Sonica.…”

Section: Introductionmentioning

confidence: 99%

“…Early flexible/stretchable electronics were mostly in the forms of wavy architectures and “island-bridge” designs. − Serpentine designs were later introduced to offer an ultrahigh stretchability, without evidence reduction of the density of functional elements. − Other structural design concepts, such as kirigami, − spiral, − and fractal designs, − were also proposed to render high levels of stretchability for a limited prescribed space of the structural layout. Based on these design concepts, various planar flexible/stretchable electronic devices were fabricated, achieving applications in diverse areas, such as daily healthcare, ,,, robotic machines, − multifunctional sensors, − solar cells, − and biomedical devices. ,, Despite the significant progress achieved to endow high degrees of stretchability and flexibility in electronic devices, most of these devices are still restricted in planar forms, leaving the gap of geometric shapes and structural functionalities between flexible/stretchable electronics and natural species unfilled. Consequently, it is essential to develop 3D architected flexible electronics that can better conform to complexly shaped biological objects and/or mimic 3D structural forms of natural species to realize more unique functionalities than planar counterparts.…”

Section: Introductionmentioning

confidence: 99%

Mechanically-Guided 3D Assembly for Architected Flexible Electronics

Bo,

Xu,

Yang

et al. 2023

Chem. Rev.

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Architected flexible electronic devices with rationally designed 3D geometries have found essential applications in biology, medicine, therapeutics, sensing/imaging, energy, robotics, and daily healthcare. Mechanically-guided 3D assembly methods, exploiting mechanics principles of materials and structures to transform planar electronic devices fabricated using mature semiconductor techniques into 3D architected ones, are promising routes to such architected flexible electronic devices. Here, we comprehensively review mechanically-guided 3D assembly methods for architected flexible electronics. Mainstream methods of mechanically-guided 3D assembly are classified and discussed on the basis of their fundamental deformation modes (i.e., rolling, folding, curving, and buckling). Diverse 3D interconnects and device forms are then summarized, which correspond to the two key components of an architected flexible electronic device. Afterward, structure-induced functionalities are highlighted to provide guidelines for function-driven structural designs of flexible electronics, followed by a collective summary of their resulting applications. Finally, conclusions and outlooks are given, covering routes to achieve extreme deformations and dimensions, inverse design methods, and encapsulation strategies of architected 3D flexible electronics, as well as perspectives on future applications.

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“…Elastography, an imaging modality, has emerged as a reliable diagnostic tool for measuring tissue stiffness. Ultrasound elastography imaging can be conducted with new stretchable ultrasonic patches or with commercially available products already adopted in hospitals 34 . Strain elastography and shear wave elastography (SWE) are the two major types of ultrasound elastography.…”

Section: Introductionmentioning

confidence: 99%

Quantifying tethered spinal cord tension: Ultrasound elastography results from computational, cadaveric, and intraoperative first-in-human studies

Kerensky

Paul²,

Routkevitch³

et al. 2023

Preprint

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Background Tension in the spinal cord is a trademark of tethered cord syndrome. Unfortunately, existing tests cannot quantify tension across the bulk of the cord, making the diagnostic evaluation of stretch ambiguous. A potential non-destructive metric for spinal cord tension is ultrasound-derived shear wave velocity (SWV). The velocity is sensitive to tissue elasticity and boundary conditions including strain. We use the term Ultrasound Tensography to describe the acoustic evaluation of tension with SWV. Methods Our solution “Tethered cord Assessment with Ultrasound Tensography (TAUT)” was utilized in three sub-studies: finite element simulations, a cadaveric benchtop validation, and a neurosurgical case series. The simulation computed SWV for given tensile forces. The induced tension cadaveric model validated the SWV-tension relationship. Lastly, SWV was measured intraoperatively in patients diagnosed with tethered cord who underwent surgical treatment (spinal column shortening). The surgery alleviates tension by decreasing the vertebral column length. Results Here we observe a strong linear relationship between tension and squared SWV across the preclinical sub-studies. Higher tension induces faster shear waves in the simulation (R2 = 0.984) and cadaveric (R2 = 0.951) models. The SWV decreases in all neurosurgical procedures (p<0.001). Moreover, TAUT has a c-statistic of 0.962 (0.92-1.00), detecting all tethered cords. Conclusions This study presents the first clinical metric of spinal cord tension. Strong agreement among computational, cadaveric, and clinical studies demonstrates the utility of ultrasound-induced SWV for quantitative intraoperative feedback. This technology is positioned to enhance tethered cord diagnosis, treatment, and post-operative monitoring as it differentiates stretched from healthy cords.

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Stretchable ultrasonic arrays for the three-dimensional mapping of the modulus of deep tissue

Cited by 48 publications

References 86 publications

Bioadhesive Technology Platforms

Bioadhesive Technology Platforms

Mechanically-Guided 3D Assembly for Architected Flexible Electronics

Quantifying tethered spinal cord tension: Ultrasound elastography results from computational, cadaveric, and intraoperative first-in-human studies

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