Stretching DNA in polymer nanochannels fabricated by thermal imprint in PMMA

Thamdrup, Lasse Højlund Eklund; Klukowska, Anna; Kristensen, Anders

doi:10.1088/0957-4484/19/12/125301

Cited by 74 publications

(68 citation statements)

References 38 publications

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“…15. Further extensions to the fabrication of optic fluidic channels as lab-on-chip can be found in numerous publications [143][144][145][146][147][148]. A further step toward high-throughput application by which is simply the difference of the expansions between the circles and the dots.…”

Section: Nanofluidic Channelsmentioning

confidence: 99%

Applications of nanoimprint lithography/hot embossing: a review

Chen

2015

Appl. Phys. A

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This review concentrates on the applications of nanoimprint lithography (NIL) and hot embossing for the fabrications of nanolectronic devices, nanophotonic metamaterials and other nanostructures. Technical challenges and solutions in NIL such as nanofabrication of templates, removal of residual resist, pattern displacement in thermal NIL arising from thermal expansion are first discussed. In the nanofabrication of templates, dry etch in plasma for the formation of multi-step structures and ultra-sharp tip arrays in silicon, nanophotonic chiral structures with high aspect ratio in SiC are demonstrated. A bilayer technique for nondestructive removal of residual resist in thermal NIL is described. This process is successfully applied for the fabrication of T-shape gates and functional high electron mobility transistors. However, pattern displacement intrinsically existing in thermal NIL/hot embossing owing to different thermal expansions in the template and substrate, respectively, limits its further development and scale-up. Low temperature even room temperature NIL (RTNIL) was then proposed on HSQ, trying to eliminate the pattern distortion by avoiding a thermal loop in the imprint. But, considerable pressure needed in RTNIL turned the major attentions to the development of UVcuring NIL in UV-curable monomers at low temperature. A big variety of applications by low-temperature UV-curing NIL in SU-8 are described, including high-aspect-ratio phase gratings, tagging technology by nanobarcode for DNA sequencing, nanofluidic channels, nanophotonic metamaterials and biosensors. Hot embossing, as a parallel technique to NIL, was also developed, and its applications on ferroelectric polymers as well as metals are reviewed. Therefore, it is necessary to emphasize that this review is mainly attempted to review the applications of NIL/embossing instead of NIL technique advances.

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Section: Nanofluidic Channelsmentioning

confidence: 99%

Applications of nanoimprint lithography/hot embossing: a review

Chen

2015

Appl. Phys. A

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“…Some phenomena such as overlapped electric double layers, reduced electro osmotic flow, increased viscosity, ion enrichment as well as depletion emerge in nanochannel. These special phenomena make nanofluidic system a key tool for lots of special usages, for example, nanofluidic devices are the main tool for manipulating DNA, proteins, small molecules and nanoparticles, with strong effects of surface force and confinement (Thamdrup et al 2008).…”

Section: Introductionmentioning

confidence: 99%

“…But these devices suffer from limitations such as low throughput and high cost. Recently, polymers have been increasingly employed as substrates of nanofluidic devices due to their advantages of lowcost, disposability and wide range of materials available (Thamdrup et al 2008, Abgrall et al 2007). Additionally, molding techniques present attractive solutions to fabrication of polymer nanochannels.…”

Section: Introductionmentioning

confidence: 99%

Bonding of planar poly (methyl methacrylate) (PMMA) nanofluidic channels using thermal assisted ultrasonic bonding method

et al. 2010

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Because of extremely small dimensions of nanochannels and low rigidity of polymer, most bonding techniques which are suitable for sealing polymer microscale channels (width and depth in tens to hundreds microns) are not competent for bonding of polymer nanochannels. In this study, a new thermal assisted ultrasonic bonding method for sealing poly (methyl methacrylate) (PMMA) nanochannels was presented. Substrates were preheated to 30-40°C lower than glass transition temperature (T g ) of the material by hot plate. Then low amplitude ultrasonic vibration was employed to generate facial heat at the interface of the substrates. Influences of preheating temperature on bonding strength and dimension loss were studied. The nanochannels were successfully bonded with depth loss less than 5.3% (10.6 nm) and bonding strength of 0.21 J/cm 2 at the preheating temperature of 70°C. Thermal assisted ultrasonic bonding is proven to be competent for bonding of polymer nanochannels with high bonding strength, low dimension loss and short bonding time.

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“…Microfabrication techniques are largely contributing to design and fabricate nano-and micropatterned devices for singlemolecule manipulation, probing, and sensing. For instance, nanopores [9], nanochannels [10][11][12], nanomechanical sensors [13], nanoantennas [14,15], and more generally laboratory-on-chips [16,17] are the ultimate developments of micronanotechnology aimed at single-molecule detection. In this paper, we describe how our micro-and nanofabricated superhydrophobic surfaces can be used to concentrate and vehiculate to specific detection points the analyte to achieve single-molecule detection with a high signal-to-noise ratio, allowing X-ray diffraction, Raman spectroscopy, and electron microscopy characterizations.…”

mentioning

confidence: 99%

Superhydrophobic Devices Molecular Detection

Limongi

Ferrara

Das

et al. 2014

Novel Approaches for Single Molecule Activation and Detection

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Recent advances in the single-molecule detection and manipulation provided unexpected solutions for the understanding of the physio-pathological behavior of individual biological macromolecules. Modern techniques of patterning at the micro-and nanometer scale combined with chemical treatments are being used to create surfaces that stretch the hydrophobic behavior to the limit. The ability to create surfaces with high static water contact angles (usually greater than 150°) is essential for a variety of applications, ranging from the development of biosensors to the implementation of sensitive and reliable single-molecule collection and sample preparation methods. Thus, superhydrophobic devices could be considered as nano-biotechnological single-molecule detection tools that can be applied to a wide range of high-resolution studies. To outline the paper, singlemolecule detection topics and theoretical principles of superhydrophobicity are first introduced. A comprehensive overview is then given, describing how different types of devices with superhydrophobic surfaces are realized. Finally, the usefulness of the presented devices for a wide range of applications and the concluding comments are proposed.

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Stretching DNA in polymer nanochannels fabricated by thermal imprint in PMMA

Cited by 74 publications

References 38 publications

Applications of nanoimprint lithography/hot embossing: a review

Applications of nanoimprint lithography/hot embossing: a review

Bonding of planar poly (methyl methacrylate) (PMMA) nanofluidic channels using thermal assisted ultrasonic bonding method

Superhydrophobic Devices Molecular Detection

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