Stretta Radiofrequency Treatment for GERD: A Safe and Effective Modality

Franciosa, Mark; Mashimo, Hiroshi

doi:10.1038/ajg.2013.275

Cited by 23 publications

(25 citation statements)

References 35 publications

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“…The RF treatment significantly improved heartburn scores, GERD HRQL scores, and general QoL scores in all patients after 8 years; these results are comparable to what was recorded in shorter term follow-up patient cohorts with similar study design [15]. The procedure satisfaction superior to that achieved with prior drug therapy, although acidic exposure time was not significantly superior in this study to baseline values after 8 years, might be due (1) to the little cohort of data evaluable for this time of follow-up and (2) mostly to the fact that RF delivery might improve reflux and dyspepsia symptoms related to delayed gastric emptying [16].…”

Section: Discussionsupporting

confidence: 75%

Durability of Stretta Radiofrequency Treatment for GERD: Results of an 8-Year Follow-Up

Rotondano²,

Cento

et al. 2014

Gastroenterology Research and Practice

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From June 2002 to March 2013 26 patients that underwent Stretta procedure (16 females, 10 males) reached to date an eight-year follow-up. Primary end point of the study was to verify the durability of the procedure at this time. All patients underwent clinical evaluation by upper endoscopy, oesophageal pressure, and pH studies. For each patient 8-year data were compared to those recorded at baseline and at 4 years. There was a significant decrease in both heartburn and GERD HRQL scores at 4 years (P = 0.001) and at 8 years (P = 0.003) as well as a significant increase of QoL scores at each control time (mental SF-36 and physical SF-36, P = 0.001). After 4 and 8 years, 21 patients (80.7%, P = 0.0001) and 20 patients (76.9%, P = 0.0001) were completely off PPIs. Median LES pressure did not show significant amelioration at 4 and 8 years and mean oesophageal acid exposure significantly improved at 4 years (P = 0.001) but returned to baseline values after 8 years. This further follow-up study of ours from four to eight years confirms that RF energy delivery for GERD provides durable improvement in symptoms and in quality of life and reduces antireflux drugs consumption.

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Section: Discussionsupporting

confidence: 75%

Durability of Stretta Radiofrequency Treatment for GERD: Results of an 8-Year Follow-Up

Rotondano²,

Cento

et al. 2014

Gastroenterology Research and Practice

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“…The Stretta procedure is a minimally invasive endoscopic procedure that delivers radiofrequency energy using the Stretta system . However, we used a RFA device, MER‐200GA, that was developed in China.…”

Section: Discussionmentioning

confidence: 99%

Radiofrequency ablation is safe and effective in the treatment of Chinese patients with gastroesophageal reflux disease: A single‐center prospective study

Liu

Meng

Han

et al. 2019

J of Digest Diseases

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Objective: This study aimed to evaluate the safety and efficiency of radiofrequency ablation (RFA) in Chinese patients with gastroesophageal reflux disease (GERD).Methods: This was a single-center, prospective study including 27 Chinese patients with GERD. The outcomes in all patients were evaluated before and at 3, 6, and 12 months after RFA, including their GERD health-related quality of life (GERD-HRQL) score, esophageal acid exposure, DeMeester score, lower esophageal sphincter (LES) resting pressure, and patient's satisfaction with symptom control. Furthermore, rabeprazole sodium (RS) administration, reflux esophagitis (RE), and intraoperative and postoperative complications were also evaluated.Results: RFA treatment significantly reduced the GERD-HRQL score, the percentage of time that esophageal pH < 4, and the DeMeester score, and significantly increased the LES resting pressure in GERD patients. A need for RS administration was reduced and RE symptoms were relieved. Satisfaction rate of 92.6% and 96.3% was reported by these patients at 6 and 12 months post-treatment, respectively. Mild bleeding (<20 mL) occurred in one patient during RFA, and no serious intraoperative and postoperative complications were observed.Conclusion: RFA is safe and effective in the treatment of GERD in Chinese patients. K E Y W O R D Sgastroesophageal reflux, peptic esophagitis, quality of liferadiofrequency ablation

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“…While the exact mechanism of action is unclear, RFED may work by increasing LES pressure secondary to inflammation with subsequent fibrosis, decreasing esophagogastric junction compliance, reducing TLESR by neural modulation of the distal esophagus, or by improving gastric emptying. 11 …”

Section: Introductionmentioning

confidence: 99%

Review of antireflux procedures for proton pump inhibitor nonresponsive gastroesophageal reflux disease

Hillman

Yadlapati

Whitsett

et al. 2017

Diseases of the Esophagus

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Introduction Up to 40% of patients with gastroesophageal reflux disease (GERD) report persistent symptoms despite proton pump inhibitor (PPI) therapy. This review outlines the evidence for surgical and endoscopic therapies for the treatment of PPI non-responsive GERD. Material and Methods A literature search for GERD therapies from 2005–2015 in PubMed, EMBASE, Cochrane Central Register of Controlled Trials, and the Cochrane Database of Systematic Reviews identified unique 2928 citations. Of those, 45 unique articles specific to surgical and endoscopic therapies for PPI non-responsive GERD were reviewed. Results Laparoscopic fundoplication (n=19) provides symptomatic and physiologic relief out to 10 years, though efficacy wanes with time. Magnetic sphincter augmentation (n=6) and transoral incisionless fundoplication (n=9) improve symptoms in PPI non-responders, and may offer fewer side effects than fundoplication, though long-term follow-up is lacking. Radiofrequency energy delivery (n=8) has insufficient evidence for routine use in treating PPI non-responsive GERD. Electrical stimulator implantation (n=1) and endoscopic mucosal surgery (n=2) are emerging therapies for the treatment of GERD. Discussion Laparoscopic fundoplication remains the most proven therapeutic approach. Newer anti-reflux procedures such as magnetic sphincter augmentation and transoral incisionless fundoplication offer alternatives with varying degrees of success, durability, and side effect profiles that may better suit individual patients. Larger head-to-head comparison trials are needed to better characterize the difference in symptom response and side effect profiles.

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Stretta Radiofrequency Treatment for GERD: A Safe and Effective Modality

Cited by 23 publications

References 35 publications

Durability of Stretta Radiofrequency Treatment for GERD: Results of an 8-Year Follow-Up

Durability of Stretta Radiofrequency Treatment for GERD: Results of an 8-Year Follow-Up

Radiofrequency ablation is safe and effective in the treatment of Chinese patients with gastroesophageal reflux disease: A single‐center prospective study

Review of antireflux procedures for proton pump inhibitor nonresponsive gastroesophageal reflux disease

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