Stria Vascularis in Mániàre's Disease: A Quantitative Histopathological Study

Masutani, Haruhiko; Takahashi, Haruo; Sando, Isamu

doi:10.1016/s0385-8146(12)80034-4

Cited by 19 publications

(6 citation statements)

References 15 publications

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“…The stria vascularis is a rich vascular plexus in the cochlea with ability to regulate electrolytes (Axelsson, 1968; Duball et al, 1980), and is also believed to be the one of the primary sites of endolymph production. Atrophy of the stria vascularis in patients with Meniere's disease compared to normal controls has been documented (Masutani et al, 1992; Ishiyama et al, 2007), as well as in aging, ototoxicity and noise exposure (Hawkins, 1973). A thickening of the strial capillary BMs in the animal model of Alport's syndrome, the COL4A3 deficient mouse, is associated with hearing loss (Cosgrove et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

Immunocytochemical distribution of WARP (von Willebrand A domain-related protein) in the inner ear

et al. 2011

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The basic components of the epithelial, perineural and perivascular basement membranes in the inner ear have been well-documented in several animal models and in the human inner ear. The von Willebrand A domain-related protein (WARP) is an extracellular matrix molecule with restricted expression in cartilage, and a subset of basement membranes in peripheral nerves, muscle and central nervous system vasculature. It has been suggested that WARP have an important role in maintaining the blood-brain barrier. To date no studies on WARP distribution have been performed in the inner that is equipped with an intricate vasculature network. In the present study we determined the distribution of WARP by immunocytochemistry in the human inner ear using auditory and vestibular endorgans microdissected from human temporal bones obtained at autopsy. All subjects (n=5, ages 55-87 years old) had documented normal auditory and vestibular function. We also determined the WARP immunolocalization in the mouse inner ear. WARP-immunoreactivity localized to the vasculature throughout the stroma of the cristae ampullaris, the maculae utricle and saccule in the human and mouse. In the human and mouse inner ear, WARP-immunoreactivity delineated blood vessels located in the stria vascularis, spiral ligament, sub-basilar region, stromal tissue, and the spiral and vestibular ganglia. The distinct localization of WARP in the inner ear vasculature suggests an important role in maintaining its integrity. In addition, WARP allows delineation of microvessels in the inner ear allowing the study of vascular pathology in the development of otological diseases.

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Section: Discussionmentioning

confidence: 99%

Immunocytochemical distribution of WARP (von Willebrand A domain-related protein) in the inner ear

et al. 2011

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“…Masutani et al (19) reported that the vascularity and the cross-sectional area of the stria vascularis were significantly smaller in the midmodiolar section of the cochlea in a patient with Ménière's disease compared with a normal temporal bone. Our results support their findings.…”

Section: Discussionmentioning

confidence: 99%

Histopathologic Changes of Contralateral Human Temporal Bone in Unilateral Ménière's Disease

Kariya¹,

Cüreoğlu²,

Fukushima³

et al. 2007

Otology &Amp; Neurotology

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“…This structure is also central to the production of endolymph. In temporal bone studies, relative ischemia of the stria vascularis has been demonstrated in patients with a history of MD 28,29 . Whether this observation is the result or cause of hydrops remains to be determined, but these findings serve as additional evidence that dysregulation of the electrochemical gradient may be a pathophysiologic mechanism.…”

Section: Discussionmentioning

confidence: 99%