Striae distensae in darker skin types: the influence of melanocyte mechanobiology

Piérard-Franchimont, C; Hermanns, Jean‐François; Hermanns‐Lê, Trinh; Pierard, Gérald

doi:10.1111/j.1473-2165.2005.00306.x

Cited by 28 publications

(43 citation statements)

References 25 publications

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“…Rarely, in people with darker skin, striae appear darker because of increased melanization as striae cerulae (blue) or striae nigrae (black) 1–4. The color of SD is linked to the stage of their evolution and to the influence of melanocyte mechanobiology 5. Also, in case of striae nigrae and striae cerulae, the releasing of cytokines, such as the stem cell factor and hepatocyte growth factor, may induce epidermal hyperpigmentation 2…”

Section: Introductionmentioning

confidence: 99%

Improvement of skin condition in striae distensae: development, characterization and clinical efficacy of a cosmetic product containing Punica granatum seed oil and Croton lechleri resin extract

Bogdan¹,

Iurian

Tomuță

et al. 2017

DDDT

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Striae distensae are a frequent skin condition associated with pregnancy, weight change or lack of skin elasticity. The aim of this research was to obtain a topical product containing herbal active ingredients with documented antioxidant and anti-inflammatory activity (Punica granatum seed oil and Croton lechleri resin extract) and demonstrate its positive effect on prevention and treatment of striae distensae. First, the cream base formulation was optimized through experimental design. Secondly, the cream containing the two active ingredients was investigated in an interventional nonrandomized clinical trial. The clinical outcome was assessed through biophysical parameters and ultrasonographic evaluation. The state of the skin was evaluated by biophysical measurements and ultrasonography at the beginning of the study and after 3 and 6 weeks. The experimental design was successfully used to set the best ranges for the technological and formulation factors to obtain a cosmetic formulation with optimal characteristics. The study of clinical efficacy on the optimal formulation revealed an increase in the dermis thickness, hydration and elasticity values in both groups after 6 weeks of cream application. The new oil-in-water cream containing P. granatum seed oil and C. lechleri resin extract can be helpful in the prevention or improving of skin changes associated with striae.

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Section: Introductionmentioning

confidence: 99%

Improvement of skin condition in striae distensae: development, characterization and clinical efficacy of a cosmetic product containing Punica granatum seed oil and Croton lechleri resin extract

Bogdan¹,

Iurian

Tomuță

et al. 2017

DDDT

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“…The livid facial appearance, especially marked on the cheeks, is due to the skin thinning at a site where the subpapillary venous plexus is nearer the surface than in most other body sites. Striae distensae are the results of loosening structure of the dermis at sites of maximal stress and appear to represent elastic fibre failure owing to the stress [44,45]. These lesions are normally evident to some degree in adolescence and pregnant women, but are more prominent in Cushing syndrome.…”

Section: Endocrinopathies and The Skinmentioning

confidence: 99%

Skin in maturity: the endocrine and neuroendocrine pathways

Quatresooz

Piérard‐Franchimont

Kharfi

et al. 2007

Intern J of Cosmetic Sci

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SynopsisIrrespective of age, most of the skin components are under the physiological control of endocrine and neuroendocrine factors. There is evidence that skin ageing appears complex showing much interindividual variability. Conceptually, ageing is a single biological process that is influenced and modulated by a series of various internal and exogenous factors. Among them, hormones and neuroendocrine signals play key roles in several ways. Ageing of most endocrine glands will in turn alter the skin biology. In addition, the age-related reduction in the intrinsic neuroendocrine activity of the skin will also alter the ageing rate of this organ. At last, various endocrinopathies will boost or conversely decrease the severity of the signs of cutaneous ageing. Ré suméIndépendamment de l'âge, la plupart des composants de la peau sont sous le contrôle physiologique de facteurs endocriniens et neuroendocriniens. Il semble évident, que le vieillissement cutané apparaît complexe, révélant une grande variabilité interindividuelle. Conceptuellement, le vieillissement est un processus biologique unique qui est influencé et modulé par une ensemble de divers facteurs internes et externes. Parmi eux, les hormones et les signaux neuroendocriniens jouent des rôles clés de diverses manières. D'une part, le vieillissement de la plupart des glandes endocrines va, par voie de conséquence, altérer la biologie cutanée. D'autre part, la réduction liée à l'âge de l'activité neuroendocrinienne intrinsèque de la peau altère aussi la progression du vieillissement de cet organe. Enfin, diverses endocrinopathies peuvent accélérer ou, en revanche, réduire la sévérité des signes du vieillissement cutané.

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“…9 Cushing syndrome or long term administration of topical/oral corticosteroids may cause the developing of striae. 5,[10][11][12][13] Genetic susceptibility can definitely have a major role as well; however, the precise mechanism has not completely elucidated. Tung et al performed some accurate genome analysis and demonstrated the collapse of elastic microfibrils as the etiology of some cases of striae distensae.…”

Section: Introductionmentioning

confidence: 99%

Fractionated CO2 Laser in the Treatment of Striae Alba in Darker Skinned Patients - A Prospective Study

et al. 2017

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Introduction: In recent years, the positive effect of fractional CO 2 laser on increasing collagen fibers, and consequently its effect on treating striae has been suggested. The present study aims to assess the effectiveness of CO 2 fractional laser 10600-nm in the treatment of striae alba. Methods: In this prospective clinical trial, 2 treatment sessions of fractional CO 2 laser with 4-week interval was given to 30 patients with striae alba. Cutaneous resonance running time (CRRT) was measured at baseline and at week 4 and 3 months after the last session of laser therapy. The level of improvement was assessed by 2 independent dermatologists and patients after 3 months of follow up. Results: 16.7% of patients had moderate improvement, 63.3% had minimal improvement, and 20% had no improvement. A statistical significant difference was found in median CRRT during the study (P < 0.0001). The median CRRT levels were significantly higher in week 4 and 3 months after the last treatment compared to the baseline (both P < 0.001). Likewise, a significant increase was observed in median CRRT level from week 4 till the end of study (P < 0.001). Evaluation of participant satisfaction revealed that 10% were very satisfied, 10% satisfied, 3.3% slightly satisfied, and 76.7% unsatisfied. Conclusion: Striae alba remain a challenging condition to treat. The treatment of striae alba with CO2 fractional laser results in minimal improvement with mild side effects.

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Striae distensae in darker skin types: the influence of melanocyte mechanobiology

Cited by 28 publications

References 25 publications

Improvement of skin condition in striae distensae: development, characterization and clinical efficacy of a cosmetic product containing <em>Punica granatum</em> seed oil and <em>Croton lechleri</em> resin extract

Improvement of skin condition in striae distensae: development, characterization and clinical efficacy of a cosmetic product containing <em>Punica granatum</em> seed oil and <em>Croton lechleri</em> resin extract

Skin in maturity: the endocrine and neuroendocrine pathways

Fractionated CO2 Laser in the Treatment of Striae Alba in Darker Skinned Patients - A Prospective Study

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