Striatal Volume Increase After Six Weeks of Selective Dopamine D2/3 Receptor Blockade in First-Episode, Antipsychotic-Naïve Schizophrenia Patients

Andersen, Helle G.; Raghava, Jayachandra Mitta; Svarer, Claus; Wulff, Sanne; Johansen, Louise Baruël; Antonsen, Patrick K.; Nielsen, Mette Ødegaard; Rostrup, Egill; Vernon, Anthony C.; Jensen, Lars T.; Pinborg, Lars H.; Glenthøj, Birte; Ebdrup, Bjørn H

doi:10.3389/fnins.2020.00484

Cited by 18 publications

(14 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In 10 studies patients were treated with both FGAs and SGAs after baseline MRI scan ( 14 , 15 , 20 , 28 , 37 , 39 , 47 – 49 , 52 ). Other 24 studies observed brain changes after treatment with SGAs ( 16 , 17 , 24 – 27 , 30 – 36 , 38 , 40 , 41 , 43 – 46 , 50 , 51 , 53 , 54 ). Only two studies had no clear information of medication ( 29 , 42 ).…”

Section: Resultsmentioning

confidence: 98%

“…All additional studies included 9 structural studies ( 16 , 44 , 48 – 54 ) and 8 functional studies ( 17 , 40 – 43 , 45 – 47 ). Finally, a total of 36 longitudinal studies was included in this review with good quality (mean score = 8.78) ( Supplementary Table 1 ), including 21 studies ( 14 – 16 , 27 – 30 , 32 , 33 , 35 – 37 , 39 , 44 , 48 – 54 ) on brain structure and 15 studies ( 17 , 20 , 24 – 26 , 31 , 34 , 38 , 40 – 43 , 45 – 47 ) on brain function ( Figure 1 ).…”

Section: Resultsmentioning

confidence: 99%

“…Among structural MRI studies, 17 studies investigated gray matter volume alterations ( 14 – 16 , 27 – 30 , 35 , 36 , 39 , 48 – 54 ). In particular, four studies used Diffusion Tensor Imaging (DTI) to assess the white matter microstructure ( 32 , 33 , 37 , 44 ).…”

Section: Resultsmentioning

confidence: 99%

“…One of these studies observed that greater volume of the prefrontal cortex was associated with improvement in negative symptoms ( 30 ). Regarding the striatum, amisulpride monotherapy induced hypertrophy of the structure ( 27 ) but quetiapine monotherapy caused hypotrophy ( 16 ). In these two studies, it was showed that the reductions in positive symptoms were associated with striatal volume increases after the administration of antipsychotics ( 27 ), while striatal volume loss was related to low quetiapine dose ( 16 ).…”

Section: Resultsmentioning

confidence: 99%

“…Regarding the striatum, amisulpride monotherapy induced hypertrophy of the structure ( 27 ) but quetiapine monotherapy caused hypotrophy ( 16 ). In these two studies, it was showed that the reductions in positive symptoms were associated with striatal volume increases after the administration of antipsychotics ( 27 ), while striatal volume loss was related to low quetiapine dose ( 16 ). As to the subregions of striatum, such as the caudate and putamen, their gray matter consistently increased in patients after antipsychotic treatment ( 15 , 49 , 53 , 54 ).…”

Section: Resultsmentioning

confidence: 99%

See 4 more Smart Citations

The Effects of Antipsychotic Treatment on the Brain of Patients With First-Episode Schizophrenia: A Selective Review of Longitudinal MRI Studies

et al. 2021

View full text Add to dashboard Cite

A large number of neuroimaging studies have detected brain abnormalities in first-episode schizophrenia both before and after treatment, but it remains unclear how these abnormalities reflect the effects of antipsychotic treatment on the brain. To summarize the findings in this regard and provide potential directions for future work, we reviewed longitudinal structural and functional imaging studies in patients with first-episode schizophrenia before and after antipsychotic treatment. A total of 36 neuroimaging studies was included, involving 21 structural imaging studies and 15 functional imaging studies. Both anatomical and functional brain changes in patients after treatment were consistently observed in the frontal and temporal lobes, basal ganglia, limbic system and several key components within the default mode network (DMN). Alterations in these regions were affected by factors such as antipsychotic type, course of treatment, and duration of untreated psychosis (DUP). Over all we showed that: (a) The striatum and DMN were core target regions of treatment in schizophrenia, and their changes were related to different antipsychotics; (b) The gray matter of frontal and temporal lobes tended to reduce after long-term treatment; and (c) Longer DUP was accompanied with faster hippocampal atrophy after initial treatment, which was also associated with poorer outcome. These findings are in accordance with previous notions but should be interpreted with caution. Future studies are needed to clarify the effects of different antipsychotics in multiple conditions and to identify imaging or other biomarkers that may predict antipsychotic treatment response. With such progress, it may help choose effective pharmacological interventional strategies for individuals experiencing recent-onset schizophrenia.

show abstract

Section: Resultsmentioning

confidence: 98%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

The Effects of Antipsychotic Treatment on the Brain of Patients With First-Episode Schizophrenia: A Selective Review of Longitudinal MRI Studies

et al. 2021

View full text Add to dashboard Cite

show abstract

Contrasting Case-Control and Normative Reference Approaches to Capture Clinically Relevant Structural Brain Abnormalities in Patients With First-Episode Psychosis Who Are Antipsychotic Naive

et al. 2022

View full text Add to dashboard Cite

ImportanceTo make progress toward precision psychiatry, it is crucial to move beyond case-control studies and instead capture individual variations and interpret them in the context of a normal range of biological systems.ObjectiveTo evaluate whether baseline deviations from a normative reference range in subcortical volumes are better predictors of antipsychotic treatment response than raw volumes in patients with first-episode psychosis (FEP) who were naive to antipsychotic medication.Design, Setting, and ParticipantsIn this prospective longitudinal study, patients with first-episode psychosis who were referred from different clinical settings (emergency department, inpatient units, and outpatient clinics) at the University of Alabama at Birmingham were included. A total of 286 patients were screened, 114 consented, 104 enrolled in the treatment trial, and 85 completed the trial. Patients were observed for 16 weeks. Controls were matched by age and sex. Data were collected between June 2016 and July 2021, and data were analyzed from August 2021 to June 2022.InterventionsRisperidone on a flexible dosing scheme for 16 weeks. There was an option to switch to aripiprazole for excessive adverse effects.Main Outcomes and MeasuresThe main outcome of this study was to evaluate, in patients with FEP who were naive to antipsychotic medication, the association of baseline raw volumes and volume deviations in subcortical brain regions with response to antipsychotic medication. Raw brain volumes or volume deviation changes after treatment were not examined.ResultsOf 190 included participants, 111 (58.4%) were male, and the mean (SD) age was 23.7 (5.5) years. Volumes and deviations were quantified in 98 patients with FEP, and data from 92 controls were used as comparison for case-control contrasts and reference curve calibration. In case-control contrasts, patients with FEP had lower raw thalamus (P = .002; F = 9.63; df = 1), hippocampus (P = .009; F = 17.23; df = 1), amygdala (P = .01; F = 6.55; df = 1), ventral diencephalon (P = .03; F = 4.84; df = 1), and brainstem volumes (P = .004; F = 8.39; df = 1). Of 98 patients, 36 patients with FEP (36%) displayed extreme deviations. Associations with treatment response significantly differed between raw volume and deviation measures in the caudate (z = −2.17; P = .03) and putamen (z = −2.15; P = .03).Conclusions and RelevanceThese data suggest that normative modeling allows capture of interindividual heterogeneity of regional brain volumes in patients with FEP and characterize structural pathology in a clinically relevant fashion. This holds promise for progress in precision medicine in psychiatry, where group-level studies have failed to derive reliable maps of structural pathology.

show abstract

Intracranial and subcortical volumes in adolescents with early‐onset psychosis: A multisite mega‐analysis from the ENIGMA consortium

Gurholt

Lonning

Nerland

et al. 2020

Human Brain Mapping

View full text Add to dashboard Cite

show abstract

Striatal Volume Increase After Six Weeks of Selective Dopamine D2/3 Receptor Blockade in First-Episode, Antipsychotic-Naïve Schizophrenia Patients

Cited by 18 publications

References 56 publications

The Effects of Antipsychotic Treatment on the Brain of Patients With First-Episode Schizophrenia: A Selective Review of Longitudinal MRI Studies

The Effects of Antipsychotic Treatment on the Brain of Patients With First-Episode Schizophrenia: A Selective Review of Longitudinal MRI Studies

Contrasting Case-Control and Normative Reference Approaches to Capture Clinically Relevant Structural Brain Abnormalities in Patients With First-Episode Psychosis Who Are Antipsychotic Naive

Intracranial and subcortical volumes in adolescents with early‐onset psychosis: A multisite mega‐analysis from the ENIGMA consortium

Contact Info

Product

Resources

About