Striated muscle involvement in experimental oral infection by herpes simplex virus type 1

González, Manuel Machuca; Sanjuán, Norberto

doi:10.1111/jop.12051

Cited by 5 publications

(4 citation statements)

References 17 publications

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“…HSV-1 is usually acquired through direct contact with infected lesions or body fluids; typically saliva [13]. Primary HSV-1 infections in children are either asymptomatic or following an incubation period of about one week which can gives rise to mucocutaneous vesicular eruptions [14]. Neonatal infection with HSV is symptomatic in almost all cases and divided into localised, central nervous system (CNS) disease and disseminated disease.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Herpes Simplex Virus in Pregnant Women from Gangetic Plain Region of Allahabad, India

Amar¹,

Bajaj²,

Gupta³

et al. 2015

AiM

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Herpes Simplex Virus (HSV) is a common pathogen that leads to lifelong latent infection and may be associated with transmission from mother to their fetus. A total of 191 blood samples of pregnant women were collected to check the prevalence of Herpes Simplex Virus (HSV). It was observed that 124 (64.9%) and 04 (2.1%) samples were positive for HSV IgG and HSV IgM, respectively. Seropositivity of HSV IgG was the highest for third trimester and it was followed by second and first trimester; while it was the highest for first trimester for HSV IgM and it was followed by third and second trimester. Seroprevalence of HSV IgG and IgM was statistically insignificant (P > 0.05) according to gestation age. A significant correlation was observed between HSV IgG and age groups of pregnant women; while it was insignificant for HSV IgM. Seroprevalence of HSV IgG + IgMwas 32 (53.3%), 61 (66.3%), and 27 (69.2%) for first, second and third trimester, respectively. Seroprevalence of HSV IgG + IgM + group was 02 (3.3%), 01 (1.1%) and 01 (2.6%) for first, second and third trimester, respectively. Seroprevalence of HSV IgG -IgM -group was 26 (43.3%), 30 (32.6%), and 11 (28.2%) for first, second and third trimester, respectively.

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Section: Introductionmentioning

confidence: 99%

Prevalence of Herpes Simplex Virus in Pregnant Women from Gangetic Plain Region of Allahabad, India

Amar¹,

Bajaj²,

Gupta³

et al. 2015

AiM

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“…However, data on metabolic disorders in muscle tissue in the presence of herpetic lesion are scarce. Some studies using modern methods substantially prove that the virion fragments are fixed in the skeletal muscle (Gonzalez and Sanjuan, ) during activation of herpetic infection, which indicates the direct effect of this viral invasion on it.…”

Section: Discussionmentioning

confidence: 99%

Nerve Regeneration in Conditions of HSV‐Infection and an Antiviral Drug Influence

Gumenyuk

Рыбалко

Ryzha

et al. 2018

The Anatomical Record

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Herpes simplex virus type I (HSV-I) is a latent neuroinfection which can cause focal brain lesion. The role of HSV-infection in nerve regeneration has not been studied so far. The aim of the work was to study sciatic nerve regeneration in the presence of HSV-infection and the influence of an antiviral drug. BALB/c line mice were divided into five groups. Group 1 animals were infected with HSV-I. After resolution of neuroinfection manifestations the sciatic nerve of these animals was crushed. Group 2 mice were administered acyclovir following the same procedures. Groups 3-5 mice served as controls. Thirty days after the operation distal nerve stumps and m.gastrocnemius were studied morphologically and biochemically. Ultrastructural organization of the sciatic nerve in control animals remained intact. Morphometric parameters of the nerves from the experimental groups have not reach control values. However, in the group 1 diameter of nerve fibers was significantly smaller than in the group 2. Both nerve regeneration and m.gastrocnemius reinnervation were confirmed. The muscle hypotrophy was found in groups 1, 2, and 3 (the muscle fibers diameter decreased). Metabolic changes in the muscles of the infected animals (groups 1 and 2) were more pronounced than in control groups 3 and 4. The levels of TBA-active products, conjugated dienes, carbonyl and SH-groups were reduced in m.gastrocnemius of the experimental groups, however no significant difference associated with acyclovir administration was found. HSV-infection is not limited to the local neurodegenerative changes in the CNS but affects regeneration of the injured sciatic nerve. Anat Rec, 301:1734-1744, 2018. © 2018 Wiley Periodicals, Inc.

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“…In the skin, mucosae and eyes, HSVs access neurons by infecting sensorial nerve termini and then traveling in a retrograde manner through the axon of these cells up to the soma. Later, HSVs may reactivate from these cells and exit them through anterograde movements either, to infect other neurons that eventually may innervate the brain or infect cells located nearby the initial site of infection (Linehan et al, 2004; Gonzalez and Sanjuan, 2013).…”

Section: Introductionmentioning

confidence: 99%

Herpes Simplex Virus Evasion of Early Host Antiviral Responses

Tognarelli

Palomino

Corrales

et al. 2019

Front. Cell. Infect. Microbiol.

100

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Herpes simplex viruses type 1 (HSV-1) and type 2 (HSV-2) have co-evolved with humans for thousands of years and are present at a high prevalence in the population worldwide. HSV infections are responsible for several illnesses including skin and mucosal lesions, blindness and even life-threatening encephalitis in both, immunocompetent and immunocompromised individuals of all ages. Therefore, diseases caused by HSVs represent significant public health burdens. Similar to other herpesviruses, HSV-1 and HSV-2 produce lifelong infections in the host by establishing latency in neurons and sporadically reactivating from these cells, eliciting recurrences that are accompanied by viral shedding in both, symptomatic and asymptomatic individuals. The ability of HSVs to persist and recur in otherwise healthy individuals is likely given by the numerous virulence factors that these viruses have evolved to evade host antiviral responses. Here, we review and discuss molecular mechanisms used by HSVs to evade early innate antiviral responses, which are the first lines of defense against these viruses. A comprehensive understanding of how HSVs evade host early antiviral responses could contribute to the development of novel therapies and vaccines to counteract these viruses.

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Striated muscle involvement in experimental oral infection by herpes simplex virus type 1

Cited by 5 publications

References 17 publications

Prevalence of Herpes Simplex Virus in Pregnant Women from Gangetic Plain Region of Allahabad, India

Prevalence of Herpes Simplex Virus in Pregnant Women from Gangetic Plain Region of Allahabad, India

Nerve Regeneration in Conditions of HSV‐Infection and an Antiviral Drug Influence

Herpes Simplex Virus Evasion of Early Host Antiviral Responses

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