Striatin family proteins: The neglected scaffolds

Tanti, Goutam Kumar; Pandey, Prachi; Shreya, Smriti; Jain, Buddhi Prakash

doi:10.1016/j.bbamcr.2023.119430

Cited by 7 publications

(3 citation statements)

References 125 publications

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“…Subsequently, cell experiments further confirmed that STRN3 could promote the dephosphorylation of MST1/2 protein and YAP protein to inhibit the Hippo pathway, regulate the nuclear entry of YAP protein, and promote the transcription of related genes. As reported, STRN3 is a regulatory subunit of PP2A and forms the PP2A holoenzyme by binding to two additional subunits of PP2A (PP2Aa and PP2Ac) through its coiled‐coil domain, and further forming the STRIPAK complex 24 . Several research had already highlighted the correlation between STRIPAK complex and the Hippo pathway in tumorigenesis.…”

Section: Discussionmentioning

confidence: 90%

“…As reported, STRN3 is a regulatory subunit of PP2A and forms the PP2A holoenzyme by binding to two additional subunits of PP2A (PP2Aa and PP2Ac) through its coiledcoil domain, and further forming the STRIPAK complex. 24 Several research had already highlighted the correlation between STRIPAK complex and the Hippo pathway in tumorigenesis. Chen revealed active RhoA bound and dissociated rhophilin and NF2/Kibra from STRIPAK, inducing the STRIPAK phosphatase to catalyse the dephosphorylation of MST1/2 and MAP4Ks by binding to the PP2AC subunit.…”

Section: Discussionmentioning

confidence: 99%

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STRN3 promotes tumour growth in hepatocellular carcinoma by inhibiting the hippo pathway

Zhu,

Tang,

Fang

et al. 2024

J Cellular Molecular Medi

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HCC is a globally high‐incidence malignant tumour, and its pathogenesis is still unclear. Recently, STRN3 has been found to be elevated in various tumours, but its expression and biological functions in HCC have not been studied. In the study, clinical correlation analysis was performed on 371 liver cancer patients from TCGA database and liver cancer tissues and normal tissues from the GEO database. qRT‐PCR and western blotting were used to detect relevant proteins in cells, and CCK8 and colony formation experiments were performed to analyse cell proliferation ability. Transwell and wound healing experiments were performed to detect cell invasion ability, and flow cytometry was used to detect cell apoptosis. Single‐cell sequencing data and multiple immunofluorescence were analysed for the expression abundance and distribution of certain proteins. Immunohistochemistry was used to assess the expression of STRN3 in patients' tumour and adjacent non‐cancerous tissues. The results indicated STRN3 was highly expressed in liver tumour tissues and was closely associated with poor prognosis. Knockdown of STRN3 could significantly inhibit cell proliferation and migration ability. At the same time, we found that STRN3 could inhibit the Hippo pathway and promote the entry of YAP protein into the nucleus. Our study first found that STRN3 could promote tumour growth by inhibiting the Hippo pathway. The study of STRN3 can promote the understanding and treatment of the occurrence and development of HCC.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

STRN3 promotes tumour growth in hepatocellular carcinoma by inhibiting the hippo pathway

Zhu,

Tang,

Fang

et al. 2024

J Cellular Molecular Medi

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“…Regulatory subunit B directs PP2A holoenzyme to recognize specific substrates. Besides, the regulatory subunit of a holoenzyme complex varies with tissue type and is highly dependent on the abundance of specific B subunit in a particular tissue 55 , 56 , 57 , 58 . …”

Section: Deubiquitination Complex Platform (Dcp) Is a Potential Mecha...mentioning

confidence: 99%

Deubiquitination complex platform: A plausible mechanism for regulating the substrate specificity of deubiquitinating enzymes

Fang

et al. 2023

Acta Pharmaceutica Sinica B

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The foam cell-derived exosomal miRNA Novel-3 drives neuroinflammation and ferroptosis during ischemic stroke

Qin,

Dong,

Tang

et al. 2024

Nat Aging

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Striatin family proteins: The neglected scaffolds

Cited by 7 publications

References 125 publications

STRN3 promotes tumour growth in hepatocellular carcinoma by inhibiting the hippo pathway

STRN3 promotes tumour growth in hepatocellular carcinoma by inhibiting the hippo pathway

Deubiquitination complex platform: A plausible mechanism for regulating the substrate specificity of deubiquitinating enzymes

The foam cell-derived exosomal miRNA Novel-3 drives neuroinflammation and ferroptosis during ischemic stroke

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