Striatonigral direct pathway activation is sufficient to induce repetitive behaviors

Bouchekioua, Youcef; Tsutsui-Kimura, Iku; Sano, Hiromi; Koizumi, Miwako; Tanaka, Kenji F.; Yoshida, Kouji; Kosaki, Yutaka; Watanabe, Shigeru; Mimura, Masaru

doi:10.1016/j.neures.2017.09.007

Cited by 26 publications

(17 citation statements)

References 19 publications

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“…In this regard, recent reports propose that phasic and tonic dopamine is increased through striatal hyperinnervation in TS, which may have similar effects as the recently reported increased D1 receptor availability leading to a hyperfunctional direct pathway in patients with dystonia . Moreover, optogenetic activation of D1 receptor‐expressing medium spiny neurons can induce motor stereotypies in rodents . Thus, gathering further understanding of the association of exaggerated direct pathway activation and theta oscillations in the hyperkinetic state in dystonia, TS, and levodopa‐induced dyskinesia could help to reveal the underlying pathophysiological mechanisms …”

Section: Discussionmentioning

confidence: 70%

Pallidal and thalamic neural oscillatory patterns in tourette's syndrome

Neumann

Huebl

Brücke

et al. 2018

Annals of Neurology

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Section: Discussionmentioning

confidence: 70%

Pallidal and thalamic neural oscillatory patterns in tourette's syndrome

Neumann

Huebl

Brücke

et al. 2018

Annals of Neurology

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“…Because SNc dopamine neurons form a reciprocal loop with the dorsal striatum, dopamine rebound may represent a mechanism by which striosomes can control the timing of phasic dopamine signals in the striatum and therefore control the plasticity of their own synapses. Future work is needed to test whether self-contained dopamine rebound activity is related to the role striosomes play in repetitive behaviors (Bouchekioua et al, 2018;Canales and Graybiel, 2000) and persistent (devaluation-resistant) stimulus-response learning (Jenrette et al, 2019).…”

Section: What Is the Significance Of Striosomal Inhibition And Dopamimentioning

confidence: 99%

Functional dissection of basal ganglia inhibitory input onto SNc dopaminergic neurons

Evans

Twedell

Zhu

et al. 2019

Preprint

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Substania nigra (SNc) dopaminergic neurons show a pause-rebound firing pattern in response to aversive events. Because these neurons integrate information from predominately inhibitory brain areas, it is important to determine which inputs functionally inhibit the dopamine neurons and whether this pause-rebound firing pattern can be produced by a solely inhibitory input. Here, we functionally map geneticallydefined inhibitory projections from the dorsal striatum (striosome and matrix) and globus pallidus (GPe; parvalbumin and Lhx6) onto SNc neurons. We find that GPe and striosomal inputs both pause firing in SNc neurons, but rebound firing only occurs after inhibition from striosomes. Indeed, we find that striosomes are synaptically optimized to produce rebound and preferentially inhibit a subpopulation of ventral, intrinsically rebound-ready SNc dopaminergic neurons on their reticulata dendrites. Therefore, we describe a self-contained dendrite-specific striatonigral circuit that can produce pauserebound firing in the absence of excitatory input.

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“…Motor stereotypies have been elicited in dopamine transporter knock-out mice, suggesting the relation between stereotypies and dopamine pathways [ 26 ]. Repetitive behaviors have also been induced, modulating the striatonigral direct circuit in mice models [ 27 ]. Imaging studies in subjects with motor stereotypies found lower levels of GABA, supporting the involvement of the anterior cingulate cortex and the striatum in the pathophysiology of motor stereotypies [ 28 ].…”

Section: Introductionmentioning

confidence: 99%

Patterns of Restricted and Repetitive Behaviors in Autism Spectrum Disorders: A Cross-Sectional Video Recording Study. Preliminary Report

Grossi¹,

Caminada²,

Goffredo³

et al. 2021

Brain Sciences

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Background: Several instruments have been proposed to investigate restricted, repetitive behaviors (RRBs) in individuals with Autism Spectrum Disorder (ASD). Systematic video observations may overcome questionnaire and interview limitations to investigate RRBs. This study aimed to analyze stereotypic patterns through video recordings and to determine the correlation between the number and appearance of RRBs to ASD severity. Methods: Twenty health professionals wearing a body cam recorded 780 specific RRBs during everyday activities of 67 individuals with ASD (mean age: 14.2 ± 3.72 years) for three months. Each stereotypy was classified according to its complexity pattern (i.e., simple or complex) based on body parts and sensory channels involved. Results: The RRBs spectrum for each subject ranged from one to 33 different patterns (mean: 11.6 ± 6.82). Individuals with a lower number of stereotypies shown a lower ASD severity compared to subjects with a higher number of stereotypies (p = 0.044). No significant differences were observed between individuals exhibiting simple (n = 40) and complex patterns (n = 27) of stereotypies on ASD severity, age, sex, and the number of stereotypes. Conclusions: This study represents the first attempt to systematically document expression patterns of RRBs with a data-driven approach. This may provide a better understanding of the pathophysiology and management of RRBs.

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Striatonigral direct pathway activation is sufficient to induce repetitive behaviors

Cited by 26 publications

References 19 publications

Pallidal and thalamic neural oscillatory patterns in tourette's syndrome

Pallidal and thalamic neural oscillatory patterns in tourette's syndrome

Functional dissection of basal ganglia inhibitory input onto SNc dopaminergic neurons

Patterns of Restricted and Repetitive Behaviors in Autism Spectrum Disorders: A Cross-Sectional Video Recording Study. Preliminary Report

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