Striatum and globus pallidus control the electrical activity of reticular thalamic nuclei

Villalobos, Nelson; Oviedo-Chávez, Aldo; Alatorre, Alberto; Ríos, Alain; Barrientos, Rafael; Delgado, Alfonso; Querejeta, Enrique

doi:10.1016/j.brainres.2016.05.032

Cited by 16 publications

(9 citation statements)

References 76 publications

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“…In this study, we only recorded irregularly firing neurons. The spontaneous activity of such neurons is increased after infusion of GABA into the GP [ 83 ]. For this reason, we decided to evaluate the effect of high pallidal GABA levels on these cells and the influence of changes in pallidal GABA levels by BI analysis under basal and experimental conditions.…”

Section: Discussionmentioning

confidence: 99%

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Elevation of GABA levels in the globus pallidus disinhibits the thalamic reticular nucleus and desynchronized cortical beta oscillations

2022

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The external globus pallidus (GP) is a GABAergic node involved in motor control regulation and coordinates firing and synchronization in the basal ganglia–thalamic–cortical network through inputs and electrical activity. In Parkinson's disease, high GABA levels alter electrical activity in the GP and contribute to motor symptoms. Under normal conditions, GABA levels are regulated by GABA transporters (GATs). GAT type 1 (GAT-1) is highly expressed in the GP, and pharmacological blockade of GAT-1 increases the duration of currents mediated by GABA A receptors and induces tonic inhibition. The functional contribution of the pathway between the GP and the reticular thalamic nucleus (RTn) is unknown. This pathway is important since the RTn controls the flow of information between the thalamus and cortex, suggesting that it contributes to cortical dynamics. In this work, we investigated the effect of increased GABA levels on electrical activity in the RTn by obtaining single-unit extracellular recordings from anesthetized rats and on the motor cortex (MCx) by corticography. Our results show that high GABA levels increase the spontaneous activity rate of RTn neurons and desynchronize oscillations in the beta frequency band in the MCx. Our findings provide evidence that the GP exerts tonic control over RTn activity through the GP–reticular pathway and functionally contributes to cortical oscillation dynamics.

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Section: Discussionmentioning

confidence: 99%

“…However, the functional implications of the GP–RTn network, especially in motor control, have not yet been clarified. The ability of the GP to modulate the electrical activity of RTn neurons in vivo [ 65 , 83 ] and the involvement of the RTn in locomotor activity [ 53 ] were recently reported.…”

Section: Introductionmentioning

confidence: 99%

Elevation of GABA levels in the globus pallidus disinhibits the thalamic reticular nucleus and desynchronized cortical beta oscillations

2022

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“…Therefore, inhibition of GPe neurons may disinhibit GABAergic interneurons in the cortex to suppress firing of pyramidal cells and promote sleep. Furthermore, it has been reported that GABAergic neurons in the GPe send axons to the thalamic reticular nucleus (TRN) ( Gandia et al, 1993 ; Mastro et al, 2014 ) and regulate spiking rates of neurons in the TRN ( Villalobos et al, 2016 ). Given that direct activation of GABAergic neurons in the TRN increases the amount of NREM sleep ( Herrera et al, 2016 ; Ni et al, 2016 ), we propose that neurons in the GPe, probably PV-positive neurons, may regulate sleep-wake behavior by influencing activity of TRN neurons.…”

Section: Discussionmentioning

confidence: 99%

Striatal adenosine A2A receptor neurons control active-period sleep via parvalbumin neurons in external globus pallidus

Yuan

Wang

Dong

et al. 2017

eLife

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Dysfunction of the striatum is frequently associated with sleep disturbances. However, its role in sleep-wake regulation has been paid little attention even though the striatum densely expresses adenosine A2A receptors (A2ARs), which are essential for adenosine-induced sleep. Here we showed that chemogenetic activation of A2AR neurons in specific subregions of the striatum induced a remarkable increase in non-rapid eye movement (NREM) sleep. Anatomical mapping and immunoelectron microscopy revealed that striatal A2AR neurons innervated the external globus pallidus (GPe) in a topographically organized manner and preferentially formed inhibitory synapses with GPe parvalbumin (PV) neurons. Moreover, lesions of GPe PV neurons abolished the sleep-promoting effect of striatal A2AR neurons. In addition, chemogenetic inhibition of striatal A2AR neurons led to a significant decrease of NREM sleep at active period, but not inactive period of mice. These findings reveal a prominent contribution of striatal A2AR neuron/GPe PV neuron circuit in sleep control.

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“…Within this framework, the BG are thought to influence the connectivity between frontoparietal regions by updating goal-directed behaviour, in order to adapt to changes in the environment [73]. Another intriguing possibility is that signals from the pallidum indirectly influence posterior cortical activity via the thalamus, given its projections to several nuclei of the thalamus, such as the lateral geniculate nucleus (LGN) , reticular nucleus (TRN) [74,75] and the pulvinar [65,[76][77][78],…”

Section: Discussionmentioning

confidence: 99%

Hemispheric asymmetry of globus pallidus relates to alpha modulation in reward-related attentional tasks

Mazzetti

Staudigl

Marshall

et al. 2018

Preprint

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19 20Although basal ganglia (BG) functions have been widely explored in relation to motor 21 control, recent evidence suggests that their mechanisms extend to the domain of attentional 22 switching. We here investigated the BG involvement in reward related top-down control of 23 visual alpha-band oscillations (8 -13 Hz), which have been linked to the mechanisms 24 supporting the allocation of spatial attention. Given that items associated with contextual 25 saliency (e.g. monetary reward or loss) attract attention, it is not surprising that alpha 26 oscillations are further modulated by the saliency properties of the visual items. The 27 executive network controlling such reward-dependent modulations of oscillatory brain 28activity has yet to be elucidated, and likely relies on the contribution of subcortical regions. 29To uncover this, we investigated whether derived measures of basal ganglia (BG) structural 30 asymmetries could predict interhemispheric modulation of alpha power, during a spatial 31 attention task. We show that volumetric lateralization of the globus pallidus (GP) 32 significantly explains individual hemispheric biases in alpha power modulation. Importantly, 33 this effect varied as a function of value-saliency parings in the task. We hence provide 34 compelling evidence suggesting that the GP in humans is a node within the executive control 35 network, implicated in reward related top-down control of visual alpha oscillations during 36 saliency processing.

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Striatum and globus pallidus control the electrical activity of reticular thalamic nuclei

Cited by 16 publications

References 76 publications

Elevation of GABA levels in the globus pallidus disinhibits the thalamic reticular nucleus and desynchronized cortical beta oscillations

Elevation of GABA levels in the globus pallidus disinhibits the thalamic reticular nucleus and desynchronized cortical beta oscillations

Striatal adenosine A2A receptor neurons control active-period sleep via parvalbumin neurons in external globus pallidus

Hemispheric asymmetry of globus pallidus relates to alpha modulation in reward-related attentional tasks

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