Strictly Approximating Attributes of DNA Lesion Repair in Terms of Inherent DNA Responses to Mutability and Malignant Transformation

Abstract

Selective susceptibilities of the cellular genome for permissive emergence of mutability hot-spots are governed by specific patterns of approximate repair of lesions in terms of response to DNA damage. Given the pattern recognition of mutability as an integral approximation there is central cooperative susceptibility within such pattern responses that specify the attributes of genomic instability as contexts for approximate DNA repair. Malignant transformation is hence a para-physiologic consequence for permissive evolution of the malignant transformation of cells and for the creation of a milieu for permissive accumulation of mutability susceptibilities towards malignancy.