Striking a balance: new perspectives on homeostatic dendritic cell maturation

Bosteels, Victor; Janssens, Sophie

doi:10.1038/s41577-024-01079-5

Cited by 2 publications

References 231 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Lipid nanoparticles as a tool to dissect dendritic cell maturation pathways

Janssens,

Rennen,

Bosteels

et al. 2024

Preprint

View full text Add to dashboard Cite

Dendritic cells (DCs) are short-lived immune cells that continuously roam our body in search for foreign or self-antigens. Upon acquisition of antigen, they mature and start migrating to the lymph node to present the antigen to naïve T cells. Depending on the context wherein the antigen is acquired, DCs will mature in a homeostatic or immunogenic manner. So far, the field is lacking proper tools to distinguish between the two maturation states. Most maturation markers are shared between the two states and therefore inappropriate to use. Still, defining the proper maturation type is crucial as it determines how the DCs will instruct the T cells towards antigen expressing cells. In this study, we used a lipid nanoparticle (LNP)-based approach to steer DC maturation pathways in vivo. CITE-seq analysis allowed us to design a panel of flow cytometry markers that reliably annotates the two DC maturation states, as validated in an infection and in a tumor model. Furthermore, the data corroborated that uptake of empty LNPs in DCs induces their homeostatic maturation, in contrast to uptake of mRNA-LNPs or TLR ligand-adjuvanted LNPs, leading to distinct effector T cell outputs. This reveals that LNPs themselves are not being decoded as “danger” by cDC1s, and that the cargo is essential to provide adjuvants activity, which is highly relevant for targeted design of LNP-based therapies.

show abstract

Lipid nanoparticles as a tool to dissect dendritic cell maturation pathways

Janssens,

Rennen,

Bosteels

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

Myokines May Be the Answer to the Beneficial Immunomodulation of Tailored Exercise—A Narrative Review

Lu,

Wang,

Zhang

et al. 2024

Biomolecules

View full text Add to dashboard Cite

Exercise can regulate the immune function, activate the activity of immune cells, and promote the health of the organism, but the mechanism is not clear. Skeletal muscle is a secretory organ that secretes bioactive substances known as myokines. Exercise promotes skeletal muscle contraction and the expression of myokines including irisin, IL-6, BDNF, etc. Here, we review nine myokines that are regulated by exercise. These myokines have been shown to be associated with immune responses and to regulate the proliferation, differentiation, and maturation of immune cells and enhance their function, thereby serving to improve the health of the organism. The aim of this article is to review the effects of myokines on intrinsic and adaptive immunity and the important role that exercise plays in them. It provides a theoretical basis for exercise to promote health and provides a potential mechanism for the correlation between muscle factor expression and immunity, as well as the involvement of exercise in body immunity. It also provides the possibility to find a suitable exercise training program for immune system diseases.

show abstract

Striking a balance: new perspectives on homeostatic dendritic cell maturation

Cited by 2 publications

References 231 publications

Lipid nanoparticles as a tool to dissect dendritic cell maturation pathways

Lipid nanoparticles as a tool to dissect dendritic cell maturation pathways

Myokines May Be the Answer to the Beneficial Immunomodulation of Tailored Exercise—A Narrative Review

Contact Info

Product

Resources

About