Striking Differences in the Incidence of Childhood Celiac Disease Between Denmark and Sweden

Weile, Birgitte; Cavell, B; Nivenius, K; Krasilnikoff, P. A.

doi:10.1097/00005176-199507000-00011

Cited by 73 publications

(46 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…There was no difference in the amount of flour introduced in the first portion between cases with CD and healthy controls [18]. Several authors have also implicated divergent flour consumption as an explanation for the geographic differences in CD incidence in Europe [50,51,52]. Furthermore, it is known that the amount of gluten in the diet correlates with the mucosal damage [53,54], and we speculate that large amounts of gluten in the early non-breast milk diet could trigger more symptoms in children with CD and, thus, a diagnosis of CD.…”

Section: Amount Of Glutenmentioning

confidence: 99%

Timing of Introduction of Gluten and Celiac Disease Risk

Ludvigsson¹,

Fasano²

2012

Ann Nutr Metab

View full text Add to dashboard Cite

Breast milk is the natural nutrition for infants, but in the second half of the first year of life, complementary feeding is needed. Many complementary foods contain gluten, but gluten exposure is associated with the risk of developing celiac disease (CD). CD is a disease with considerable morbidity and mortality. Although CD is associated with certain genetic features, carrying the human leukocyte antigen haplotypes DQ2 or DQ8 (a prerequisite for CD development) cannot fully explain who will or who will not develop CD. Potential risk factors for CD include perinatal events and infant feeding practice. With the exception that children who are breastfed at and beyond gluten introduction into the diet probably may be at a lower risk of developing CD, and that heavy gluten load early in life may increase the risk of future CD, data on the impact of infant feeding are inconsistent.

show abstract

Section: Amount Of Glutenmentioning

confidence: 99%

Timing of Introduction of Gluten and Celiac Disease Risk

Ludvigsson¹,

Fasano²

2012

Ann Nutr Metab

View full text Add to dashboard Cite

show abstract

“…There is a 70 % concordance for CD in monozygotic twins (2) . Environmental factors, such as the time of initial exposure of intestinal epithelium to gluten (4) , as well as the duration of gluten exposure are also associated with the development of CD (5) .…”

Section: Introductionmentioning

confidence: 99%

Is vitamin D deficiency a feature of pediatric celiac disease?

Villanueva

Maranda

Nwosu

2012

Journal of Pediatric Endocrinology and Metabolism

View full text Add to dashboard Cite

Background: Celiac disease (CD) is an autoimmune enteropathy characterized by villus atrophy and malabsorption of essential nutrients. Vitamin D defi ciency has been described in autoimmune diseases, but its status in prepubertal children with CD has not been adequately studied. Objective: To determine the vitamin D status of prepubertal children with CD. Study design: A retrospective study of prepubertal children aged 3 -12 years with CD (n = 24) who were compared to prepubertal, non-CD children of the same age (n = 50). Children were included in the study if they had a diagnosis of CD by intestinal biopsy, and were not on a gluten-free diet (GFD). Patients were excluded if they had diseases of calcium or vitamin D metabolism, or were receiving calcium or vitamin D supplementation or had other autoimmune diseases. All subjects had their serum 25-hydroxyvitamin D [25(OH)D] level measured. Results: There was no difference in 25(OH)D level between the CD and non-CD children (27.58 ± 9.91 vs. 26.20 ± 10.45, p = 0.59). However, when the patients were subdivided into obese and non-obese groups, the non-obese CD patients had a signifi cantly higher 25(OH)D level than the obese normal children (28.39 ± 10.26 vs. 21.58 ± 5.67, p = 0.009). In contrast, there was no difference in 25(OH)D level between non-obese CD patients and non-obese normal children (28.39 ± 10.26 vs. 30.64 ± 12.08, p = 0.52). The season of 25(OH)D measurement was not a signifi cant confounder (p = 0.7). Conclusions: Our data showed no difference in 25(OH) D levels between normal children and those with CD when adjusted for body mass index.

show abstract

“…Coeliac disease is induced by prolamines (gluten) present in wheat, barley or rye [4] in genetically susceptible individuals. Timing of the introduction of gluten into the infant diet, the amount of gluten consumed and the introduction of gluten after cessation of breast-feeding have been linked to the risk of coeliac disease and type 1 diabetes [5][6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Development of autoimmunity to transglutaminase C in children of patients with type 1 diabetes: relationship to islet autoantibodies and infant feeding

Hummel

Banholzer

et al. 2006

Diabetologia

View full text Add to dashboard Cite

Aims/hypothesis Coeliac disease and transglutaminase antibodies are common in patients with type 1 diabetes and their relatives. We investigated the development of transglutaminase antibodies and analysed potential risk factors for coeliac disease autoimmunity in first-degree relatives of patients with type 1 diabetes. Methods The study was conducted by prospective observational follow-up from birth of 1,511 children at increased risk of type 1 diabetes or coeliac disease born in Germany between 1989 and 2000. Mean follow-up was to age 7.6 years. Children were tested for transglutaminase and islet autoantibodies. Children were classified as transglutaminase antibody-positive if antibodies were detected by both ELISA and radiobinding assays. Results The risk of developing transglutaminase antibodies was 4.9% by age 8 years (n=63; 95% CI, 3.7-6.1%). Transglutaminase antibodies developed at an older age than islet autoantibodies (median age, 4.9 vs 2.3 years; p<0.005), and only three children developed both transglutaminase antibodies and islet autoantibodies. Multivariate analysis indicated an increased risk of transglutaminase antibodies in children with the HLA-DRB1*03 allele (hazard ratio for heterozygous DR3, 5.5; 95% CI, 2.9-10.2; hazard ratio for homozygous DR3, 16.2; 95% CI, 6.7-39; p<0.0001) and in children with impaired uterine growth (birth weight ≤ 1st percentile, hazard ratio, 3

show abstract

Striking Differences in the Incidence of Childhood Celiac Disease Between Denmark and Sweden

Cited by 73 publications

References 0 publications

Timing of Introduction of Gluten and Celiac Disease Risk

Timing of Introduction of Gluten and Celiac Disease Risk

Is vitamin D deficiency a feature of pediatric celiac disease?

Development of autoimmunity to transglutaminase C in children of patients with type 1 diabetes: relationship to islet autoantibodies and infant feeding

Contact Info

Product

Resources

About