We investigated university students’ remote teaching experiences, how they predict psychological well-being, and whether the predictions vary depending on students’ motivation. Self-reports were collected from Finnish university students (N = 2686). Within the latent variable modeling framework, we classified students according to their expectancy-value-cost profiles, compared latent means, and tested whether the predictions differed across groups. Six groups described the data best: moderately motivated, utility-oriented, disengaged, indifferent, positively ambitious, and struggling ambitious. The groups differed significantly on remote teaching experiences and well-being, but predictions were similar across the groups: Engagement was predicted positively by evaluation of remote teaching and negatively by perceived strain, exhaustion positively by evaluation of teaching and perceived strain, and depressive symptoms by perceived strain and sense of alienation. Findings suggest that remote teaching experiences during the pandemic contribute to students’ psychological well-being in distinct ways, and that certain motivational mindsets might buffer against the negative effects.