Strobe

Nijsten, Tamar; Spuls, Phyllis I.; Stern, Robert S.

doi:10.1001/archderm.144.9.1200

Cited by 16 publications

(4 citation statements)

References 9 publications

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“…b and c). Modulating the mechanistic profile of PUVA may have great potential in improving the safety of the treatment in patients with various skin diseases because long‐term PUVA treatment increases the risk of non‐melanoma skin cancer and possibly malignant melanoma . Indeed, similar to UVB radiation PUVA is a complete carcinogen, leading to carcinogenesis by enhancing tumor initiation, promotion and/or immune suppression (reviewed in (–49)).…”

Section: Discussionmentioning

confidence: 99%

Serotonin signalling is crucial in the induction of PUVA‐induced systemic suppression of delayed‐type hypersensitivity but not local apoptosis or inflammation of the skin

Wolf

Byrne

Limón-Flores

et al. 2016

Experimental Dermatology

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Psoralen and UVA (PUVA) has immunosuppressive and proapoptotic effects, which are thought to be responsible alone or in combination for its therapeutic efficacy. However, the molecular mechanism by which PUVA mediates its effects are not well understood. Activation of the serotonin (5-hydroxytryptamine, 5-HT) pathway has been suggested to be involved in the modulation of T cell responses and found to mediate UVB-induced immune suppression. In particular, the activation of the 5-HT2A receptor has been proposed as one mechanism responsible for UV-induced immune suppression. We therefore hypothesized that 5-HT may play a role in PUVA-induced effects. The model of systemic suppression of delayed-type hypersensitivity (DTH) to Candida albicans was used to study immune function after exposure of C3H and KITW-Sh/W-Sh mice to a minimal inflammatory dose of topical PUVA. The intraperitoneal injection of the 5-HT2 receptor antagonist ketanserin or cyproheptadine or an anti-5-HT antibody immediately before PUVA exposure entirely abrogated suppression of DTH but had no significant effect on inflammation, as measured by swelling and cellular infiltration of the skin, and apoptosis as determined by the number of sunburn cells in C3H mice. Importantly, the systemic injection of 5-HT recapitulated PUVA immune suppression of DTH but did not induce inflammation or apoptosis in the skin. KITW-Sh/W-Sh mice (exhibiting myelopoietic abnormalities, including lack of 5-HT-containing mast cells) were resistant to PUVA-induced suppression of DTH but not local skin swelling. Thus, this points towards a crucial role of 5-HT signaling in PUVA-induced immune suppression but not inflammation or apoptosis in situ in the skin.

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Section: Discussionmentioning

confidence: 99%

Serotonin signalling is crucial in the induction of PUVA‐induced systemic suppression of delayed‐type hypersensitivity but not local apoptosis or inflammation of the skin

Wolf

Byrne

Limón-Flores

et al. 2016

Experimental Dermatology

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“…In order to address this, the STrengthening the Reporting of OBservational Studies in Epidemiology (STROBE) initiative developed recommendations on what should be incorporated in a precise and thorough report of an observational study. The STROBE statement and checklist were published in October 2007[ 13 , 14 ]. These reporting guidelines were envisioned to make issues such as confounding, bias, and generalizability more ostensible.…”

Section: Introductionmentioning

confidence: 99%

Quality of Reporting and Study Design of CKD Cohort Studies Assessing Mortality in the Elderly Before and After STROBE: A Systematic Review

et al. 2016

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BackgroundThe STrengthening the Reporting of OBservational studies in Epidemiology (STROBE) statement was published in October 2007 to improve quality of reporting of observational studies. The aim of this review was to assess the impact of the STROBE statement on observational study reporting and study design quality in the nephrology literature.Study DesignSystematic literature review.Setting & PopulationEuropean and North American, Pre-dialysis Chronic Kidney Disease (CKD) cohort studies.Selection Criteria for StudiesStudies assessing the association between CKD and mortality in the elderly (>65 years) published from 1st January 2002 to 31st December 2013 were included, following systematic searching of MEDLINE & EMBASE.PredictorTime period before and after the publication of the STROBE statement.OutcomeQuality of study reporting using the STROBE statement and quality of study design using the Newcastle Ottawa Scale (NOS), Scottish Intercollegiate Guidelines Network (SIGN) and Critical Appraisal Skills Programme (CASP) tools.Results37 papers (11 Pre & 26 Post STROBE) were identified from 3621 potential articles. Only four of the 22 STROBE items and their sub-criteria (objectives reporting, choice of quantitative groups and description of and carrying out sensitivity analysis) showed improvements, with the majority of items showing little change between the period before and after publication of the STROBE statement. Pre- and post-period analysis revealed a Manuscript STROBE score increase (median score 77.8% (Inter-quartile range [IQR], 64.7–82.0) vs 83% (IQR, 78.4–84.9, p = 0.05). There was no change in quality of study design with identical median scores in the two periods for NOS (Manuscript NOS score 88.9), SIGN (Manuscript SIGN score 83.3) and CASP (Manuscript CASP score 91.7) tools.LimitationsOnly 37 Studies from Europe and North America were included from one medical specialty. Assessment of study design largely reliant on good reporting.ConclusionsThis study highlights continuing deficiencies in the reporting of STROBE items and their sub-criteria in cohort studies in nephrology. There was weak evidence of improvement in the overall reporting quality, with no improvement in methodological quality of CKD cohort studies between the period before and after publication of the STROBE statement.

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“…[ 1 ] The effect of treatment is remarkable, but the PUVA (PSO and ultra violet light, type A) therapy is mutagenic and carcinogenic. [ 2,3 ] The actual mechanism of the treatment is unknown. Some people think that PSO can selectively intercalate and cross‐link the 5′‐TA dinucleotides of double‐stranded DNA (dsDNA) in the presence of long wave length UVA, which has impacts on DNA structure and function.…”

Section: Figurementioning

confidence: 99%

Effects of Psoralen on Histone‐DNA Interactions Studied by Using Atomic Force Microscopy

Zhang

2020

Macromol. Rapid Commun.

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The investigation of the DNA‐histone interactions and factors that affect such interactions in the nucleosome is essential for understanding the role of chromatin organization in all cellular processes involved in the repair, transcription, and replication of the eukaryotic genome. As a kind of photosensitive molecule, psoralen (PSO) is used in the treatment of skin disease with ultraviolet light (PSO and ultra violet light, type A). The effect of treatment is remarkable, but the side effect is also obvious. PSO can be embedded in a 5′ TA sequence in double‐stranded DNA (dsDNA), and dsDNA is mainly wrapped around a histone octamer to form a nucleosome structure in human cells. Therefore, it is very necessary to explore the influence of PSO on DNA‐histone interactions. To this end, the binding specificity and mode of DNA and histone in the presence or absence of PSO are investigated systematically. The results show that the presence of PSO (no matter if there is ultra violet light treatment) can increase the overall probability of histone binding to dsDNA while lowering the selectivity of histone binding to the specific DNA sequence in vitro. In addition, the increase of solution ionic strength can lower the ratio of histone binding to nonspecific DNA.

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Strobe

Cited by 16 publications

References 9 publications

Serotonin signalling is crucial in the induction of PUVA‐induced systemic suppression of delayed‐type hypersensitivity but not local apoptosis or inflammation of the skin

Serotonin signalling is crucial in the induction of PUVA‐induced systemic suppression of delayed‐type hypersensitivity but not local apoptosis or inflammation of the skin

Quality of Reporting and Study Design of CKD Cohort Studies Assessing Mortality in the Elderly Before and After STROBE: A Systematic Review

Effects of Psoralen on Histone‐DNA Interactions Studied by Using Atomic Force Microscopy

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