Stroke After Aortic Surgery: History of Chronic Obstructive Pulmonary Disease Is a Significant and Independent Risk Factor

Zhou, Zhandong; Raza, Syed Ali; Bhayana, Joginder N.; Rizvi, Irfan; Suresh, Adit

doi:10.1378/chest.128.4.2497

Cited by 2 publications

(3 citation statements)

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“…Research has linked infection with organisms such as chlamydia with AAU, and the mechanism of this association may be related to inappropriate or abnormal activation of a cell-mediated immune response by IL-18[46, 47]. In sarcoidosis, a condition in which AAU occurs, enhanced expression of IL-18R alpha chain has been noted in CD4 T cells[48]. …”

Section: Discussionmentioning

confidence: 99%

Genetic Dissection of Acute Anterior Uveitis Reveals Similarities and Differences in Associations Observed With Ankylosing Spondylitis

Robinson

Claushuis

Cortés

et al. 2014

Arthritis & Rheumatology

120

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Objective To use high density genotyping to investigate the genetic associations of acute anterior uveitis (AAU) in patients both with and without ankylosing spondylitis (AS). Method We genotyped 1,711 patients with AAU (either primary or with AAU and AS), 2,339 AS patients without AAU, and 10,000 controls on the Illumina Immunochip Infinium microarray. We also used data on AS patients from previous genomewide association studies to investigate the AS risk locus ANTXR2 for its putative effect in AAU. ANTXR2 expression in mouse eyes was investigated by RT-PCR. Results Comparing all AAU cases with HC, strong association was seen over HLA-B corresponding to the HLA-B27 tag SNP rs116488202. Three non-MHC loci IL23R, the intergenic region 2p15 and ERAP1 were associated at genome-wide significance (P < 5×10−8). Five loci harboring the immune-related genes IL10-IL19, IL18R1-IL1R1, IL6R, the chromosome 1q32 locus harboring KIF21B, as well as the eye related gene EYS, were also associated at a suggestive level of significance (P < 5×10−6). A number of previously confirmed AS associations demonstrated significant differences in effect size between AS patients with AAU and AS patients without AAU. ANTXR2 expression was found to vary across eye compartments. Conclusion These findings, with both novel AAU specific associations, and associations shared with AS demonstrate overlapping but also distinct genetic susceptibility loci for AAU and AS. The associations in IL10 and IL18R1 are shared with inflammatory bowel disease, suggesting common etiologic pathways.

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Section: Discussionmentioning

confidence: 99%

Genetic Dissection of Acute Anterior Uveitis Reveals Similarities and Differences in Associations Observed With Ankylosing Spondylitis

Robinson

Claushuis

Cortés

et al. 2014

Arthritis & Rheumatology

120

View full text Add to dashboard Cite

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“…The diagnosis of pulmonary sarcoidosis was established based on clinical findings and histologic evidence of noncaseating epithelioid cell granulomas, after excluding known causes of granulomatous diseases, in accordance with the American Thoracic Society/European Respiratory Society/World Association of Sarcoidosis and other Granulomatous Disorders guidelines [14]. All subjects underwent BAL, which is a routine diagnostic procedure at our hospital for patients with undiagnosed sarcoidosis, as described previously [18,19]. Serum samples were collected 30 minutes before BAL in all subjects.…”

Section: Methodsmentioning

confidence: 99%

“…All patients had provided written informed consent for their samples to be used in future clinical research [18,19]. The Institutional Review Board of Hokkaido University Hospital for Clinical Research approved the study protocols (approval No.…”

Section: Methodsmentioning

confidence: 99%

Effects of molecular structural variants on serum Krebs von den Lungen-6 levels in sarcoidosis

et al. 2012

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BackgroundSerum Krebs von den Lungen-6 (KL-6), which is classified as human mucin-1 (MUC1), is used as a marker of sarcoidosis and other interstitial lung diseases. However, there remain some limitations due to a lack of information on the factors contributing to increased levels of serum KL-6. This study was designed to investigate the factors contributing to increased levels of serum KL-6 by molecular analysis.MethodsWestern blot analysis using anti-KL-6 antibody was performed simultaneously on the bronchoalveolar lavage fluid (BALF) and serum obtained from 128 subjects with sarcoidosis.ResultsKL-6/MUC1 in BALF showed three bands and five band patterns. These band patterns were associated with the MUC1 genotype and the KL-6 levels. KL-6/MUC1 band patterns in serum were dependent on molecular size class in BALF. Significantly increased levels of serum KL-6, serum/BALF KL-6 ratio and serum soluble interleukin 2 receptor were observed in the subjects with influx of high molecular size KL-6/MUC1 from the alveoli to blood circulation. The multivariate linear regression analysis involving potentially relevant variables such as age, gender, smoking status, lung parenchymal involvement based on radiographical stage and molecular size of KL-6/MUC1 in serum showed that the molecular size of KL-6/MUC1 in serum was significant independent determinant of serum KL-6 levels.ConclusionsThe molecular structural variants of KL-6/MUC1 and its leakage behavior affect serum levels of KL-6 in sarcoidosis. This information may assist in the interpretation of serum KL-6 levels in sarcoidosis.

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Stroke After Aortic Surgery: History of Chronic Obstructive Pulmonary Disease Is a Significant and Independent Risk Factor

Cited by 2 publications

References 0 publications

Genetic Dissection of Acute Anterior Uveitis Reveals Similarities and Differences in Associations Observed With Ankylosing Spondylitis

Genetic Dissection of Acute Anterior Uveitis Reveals Similarities and Differences in Associations Observed With Ankylosing Spondylitis

Effects of molecular structural variants on serum Krebs von den Lungen-6 levels in sarcoidosis

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