Stroke and breast cancer in the United States during 2007–2017

Rethemiotaki, Irene; Rethemiotakis, Andrew

doi:10.5114/amsad.2019.86749

Cited by 6 publications

(5 citation statements)

References 19 publications

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“…Some cases series and retrospective study has showed that breast cancer is a risk factor for stroke. [ 14 ] Nilsson et al performed an observational study, and, from comparing breast cancer patients with stroke to patients without, drew the conclusion that the risk of stroke was increased in patients with breast cancer [RR = 1.12 95% CI = (1.07, 1.17)]. It seemed that breast cancer was a risk factor for stroke, especially ischemic stroke.…”

Section: Discussionmentioning

confidence: 99%

Investigating the association of breast cancer and stroke: A two-sample Mendelian randomization study

Qu,

He,

et al. 2023

Medicine

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We conducted a two-sample Mendelian randomization (MR) design to evaluate the causal relation between breast cancer and stroke. Genetic variants associated with breast cancer and stroke were both obtained from genome-wide association study summary data. The single nucleotide polymorphisms were selected as instrumental variables. Effect estimates were primarily evaluated using standard inverse variance weighted. Finally, sensitivity analyses were performed for the detection of potential pleiotropy and heterogeneity in the cause-effect evaluation. There was a causal association of ER-positive breast cancer (odds ratio = 0.11, 95% confidence interval: 0.08–0.16, P < .001), and ER-negative breast cancer (odds ratio = 1.04, 95% confidence interval: 1.00–1.07, P = .045) with stroke. MR-egger regression revealed that the cause-effect of ER-positive breast cancer (P < .001) is drove by the directional horizontal pleiotropy, while there was no directional pleiotropy in the cause-effect of ER-negative breast cancer (P = .82). Cochran Q-derived P-value from inverse variance weighted (P = .27) shown that the cause-effect of ER-negative breast cancer on stroke do not need to consider the effect of heterogeneity. In addition, the leave-one-out analysis showed no influential instruments driving the associations, suggesting robust results for all outcomes. The present MR study reveals that ER negative breast cancer increase the risk of stroke.

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Section: Discussionmentioning

confidence: 99%

Investigating the association of breast cancer and stroke: A two-sample Mendelian randomization study

Qu,

He,

et al. 2023

Medicine

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“…The literature includes studies regarding the development of stroke in various disease settings such as prostate [16] and breast cancer [17]. However, as a cardiac disorder, estimation of development of ischaemic stroke is especially clinically important for patients with PFO, where PFO closure, although still controversial, is an option that may preclude worse outcome [5,18].…”

Section: Discussionmentioning

confidence: 99%

Neutrophil to lymphocyte ratio and platelet to lymphocyte ratio are associated with cryptogenic stroke in patients with patent foramen ovale

Çağlar

Erdem

Karabulut

et al. 2020

Arch Med Sci Atheroscler Dis

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Introduction: Although most ischaemic strokes are due to cardioembolism, about 25-40% of strokes are cryptogenic. Patent foramen ovale has been associated with cryptogenic stroke; however, the precise mechanism of this association has not been demonstrated. The aim of this study was to evaluate the association between inflammatory markers and cryptogenic stroke in patients with patent foramen ovale. Material and methods: We included 206 patients with patent foramen ovale. Ninety-four (45.63%) out of 206 patients had had stroke, and 112 (54.37%) had not had stroke. The ratio of the total neutrophil count to the total lymphocyte count was defined as the neutrophil to lymphocyte ratio, and the ratio of the absolute platelet count to the absolute lymphocyte count was determined as the platelet to lymphocyte count. Results: The neutrophil to lymphocyte ratio was significantly higher in patients who had stroke than in those who did not (2.41 ±1.69 vs. 2.19 ±1.74, p = 0.047). Although the platelet to lymphocyte count was also higher in patients who had had stroke than in those who had not, it was not statistically significant (120.94 ±55.45 vs. 118.01 ±52.21, p = 0.729). 1.62 was the cutoff value for neutrophil to lymphocyte ratio to be associated with stroke with 73.4% sensitivity and 45.05% specificity (p = 0.042). Conclusions: This study demonstrated that elevated neutrophil to lymphocyte ratio and platelet to lymphocyte count could be associated with cryptogenic stroke in patients with patent foramen ovale.

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“…The high rate of BC in highly developed countries is attributed to the higher prevalence of risk factors, such as late motherhood, nulliparity, non-breastfeeding or short-term breastfeeding, early age menarche, menopause at older ages, use of oral contraceptives and hormone replacement, alcohol intake, overweight, diet rich in processed foods and red meats, physical inactivity, work shifts, unemployment having worked before, exposure to ionizing radiation such as mammography and radiotherapy and to endocrine disrupting chemicals 3 – 8 .…”

Section: Introductionmentioning

confidence: 99%

Variabilidade espacial intraurbana da mortalidade por câncer de mama e do colo do útero no município de São Paulo: análise dos fatores associados

Aguiar

Pellini

Rebolledo

et al. 2023

Rev. bras. epidemiol.

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RESUMO Objetivo: Identificar a variabilidade espacial da mortalidade por câncer de mama e colo do útero e avaliar fatores associados à mortalidade por esses cânceres no município de São Paulo. Métodos: Entre 2009 e 2016 foram registrados, no Sistema de Informações sobre Mortalidade, 10.124 óbitos por câncer de mama e 2.116 óbitos por câncer do colo do útero em mulheres com 20 anos e mais. Os registros foram geocodificados por endereço de residência e agregados segundo território adstrito. Foram realizadas modelagens de regressão espacial utilizando-se a abordagem bayesiana com estrutura de Besag-York-Mollié para verificar a associação dos óbitos com indicadores selecionados. Resultados: As taxas de mortalidade por esses cânceres apresentaram padrões espaciais inversos. As variáveis associadas à mortalidade por câncer de mama foram: tempo de deslocamento para o trabalho entre uma e duas horas (risco relativo — RR 0,97; intervalo de credibilidade — IC95% 0,93–1,00); mulheres responsáveis pelo domicílio (RR 0,97; IC95% 0,94–0,99) e óbitos por câncer de mama ocorridos em estabelecimentos privados (RR 1,04; IC95% 1,00–1,07). À mortalidade por câncer do colo do útero, estiveram associados: tempo de deslocamento para o trabalho entre meia e uma hora (RR 0,92; IC95% 0,87–0,98); rendimento domiciliar até três salários-mínimos (RR 1,27; IC95% 1,18–1,37); e razão de menores de um ano em relação à população feminina de 15 a 49 anos (RR 1,09; IC95% 1,01–1,18). Conclusão: Foram calculados os RR preditos para a mortalidade por esses cânceres, que estiveram associados às condições socioeconômicas das áreas de abrangência.

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Stroke and breast cancer in the United States during 2007–2017

Cited by 6 publications

References 19 publications

Investigating the association of breast cancer and stroke: A two-sample Mendelian randomization study

Investigating the association of breast cancer and stroke: A two-sample Mendelian randomization study

Neutrophil to lymphocyte ratio and platelet to lymphocyte ratio are associated with cryptogenic stroke in patients with patent foramen ovale

Variabilidade espacial intraurbana da mortalidade por câncer de mama e do colo do útero no município de São Paulo: análise dos fatores associados

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