Stroke and Coronary Artery Disease Are Associated With Parkinson’s Disease

Li, Qiongqiong; Wang, Cheng; Tang, Huidong; Chen, Shengdi; Ma, Jianfang

doi:10.1017/cjn.2018.56

Cited by 25 publications

(29 citation statements)

References 36 publications

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“…Our findings were compatible with previous studies, indicating that diabetes mellitus 33 , and head injury 34 were risk factors for developing AD and neurodegeneration. Compatible with previous reports, we also found that head injury 35 , cerebrovascular disease 36 , and osteoarthritis 37 were related to higher risk of PD.…”

Section: Discussionsupporting

confidence: 85%

Tinnitus and risk of Alzheimer’s and Parkinson’s disease: a retrospective nationwide population-based cohort study

Chu

Liang

Yeh

et al. 2020

Sci Rep

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Previous studies have shown that central auditory dysfunction without severe peripheral hearing loss was associated with higher incidences of cognitive decline and Alzheimer's dementia 11,12. Both hearing loss and central auditory dysfunction are associated with higher risk of developing dementia 5-10 years later 13. Uhlmann et al. 14 demonstrated an association of hearing impairment and Alzheimer's dementia. There may be a pathophysiological interplay of hearing impairment and neurodegeneration. Although the prevalence of tinnitus is not exactly related to the prevalence of hearing loss, chronic tinnitus is usually accompanied by a hearing impairment 4. Previous research revealed that chronic tinnitus was related to the anatomical brain abnormalities, including cortical grey matter reduction and reduced white matter integrity 15. In previous decades, structural and functional brain research showed the correlation between annoying tinnitus and various forms of cognitive dysfunction, especially executive control of attention and working memory 16. Such studies suggest that changes in hearing, olfaction may antecede the beginning of cognitive impairments and dementia as the strong risk factors of AD dementia 17,18. On the other hand, adequate research shows that specific sensory changes may be early biomarkers for AD 13. Previous studies have not used population-based cohort study to evaluate the relationship between tinnitus and subsequence risk of AD and PD. We applied nationwide data from the National Health Insurance (NHI) system to operate a retrospective population-based cohort study in Taiwan. This reliable data has been used for various studies, including tinnitus and AD/PD 19-21. The hypothesis of this study is that tinnitus might be related with the likelihood of subsequent diagnosis of AD and PD. We aim to determine the possibility of an association between tinnitus and a higher risk of AD and PD development. Methods Data sources. The NHI program, an essential health insurance program instituted in 1995, provided comprehensive medical care coverage to about 99% of the residents in Taiwan, including inpatient, outpatient, emergency, and traditional Chinese medicine services 22. Comprehensive information on medical visits, including diagnostic codes and prescription details according to the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) are provided by the NHI Research Database (NHIRD). NHIRD is supervised by the National Health Research Institutes, with confidentiality kept in congruence with the directives of the NHI Bureau, Taiwan. Data used in the current study are from the Longitudinal Health Insurance Database 2005 (LHID2005). LHID2005 data were methodically and randomly retracted from the NHIRD, which contains data on one million people. No significant differences in the average insured payroll-related amount, sex distribution, or age distribution between patients in the LHID2005 and those in the original NHIRD were reported by NHRI 23 .

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Section: Discussionsupporting

confidence: 85%

Tinnitus and risk of Alzheimer’s and Parkinson’s disease: a retrospective nationwide population-based cohort study

Chu

Liang

Yeh

et al. 2020

Sci Rep

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“…The effect of RAS inhibitor use on PD was evaluated in IHD patients, which could affect the incidence of parkinsonism, including PD (Q. Li et al, 2018 ). Thus, the association between RAS inhibitor use and PD in the general population should be investigated in further studies.…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of Renin-Angiotensin System Inhibitors on Parkinson’s Disease: A Nationwide Cohort Study

Kim

et al. 2022

Front. Pharmacol.

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Background: Renin-angiotensin system (RAS) inhibitors have been suggested as protective agents in Parkinson’s disease (PD). However, epidemiological evidence on the association between RAS inhibitors and the development of PD is inconsistent.Objectives: To investigate the effect of RAS inhibitors on PD risk in patients with ischemic heart disease (IHD) by type and cumulative duration of RAS inhibitors and their degree of blood-brain barrier (BBB) penetration ability.Methods: This was a propensity score-matched retrospective cohort study using 2008–2019 healthcare claims data from the Korean Health Insurance Review and Assessment database. The association between RAS inhibitor use and PD in patients with IHD was evaluated using multivariate Cox proportional hazard regression analysis. The risks are presented as adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs).Results: Over a 10-year follow-up, 1,086 of 62,228 IHD patients developed PD. The Cox regression model showed that the use of RAS inhibitors was significantly associated with a lower risk of PD (aHR = 0.75; 95% CI 0.66–0.85) than the non-use of RAS inhibitors. Specifically, this reduced risk of PD only remained with the use of BBB-crossing angiotensin II receptor blockers (ARBs) (aHR = 0.62; 95% CI = 0.53–0.74), and this association was more definite with an increasing cumulative duration. A significantly reduced risk of PD was not observed with the use of BBB-crossing angiotensin-converting enzyme inhibitors.Conclusions: The use of ARBs with BBB-penetrating properties and a high cumulative duration significantly reduces the risk of PD in IHD patients. This protective effect could provide insight into disease-modifying drug candidates for PD.

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“…The top 10 KEGG pathways (those enriched in the shortest paths) are shown in Table 6 ( Turi et al, 2019 ; Jia et al, 2021 ; Chothani et al, 2019 ; Yin et al, 2021 ; Manhas and Rath, 2020 ; Li et al, 2018 ; Nakajima et al, 2019 ; Hosseini et al, 2021 ; Critchley et al, 2018 ; Lathe et al, 2014 ; Margiotta, 2021 ; Nickel et al, 2002 ; Chen et al, 2020 ; Luo et al, 2020 ; Miller et al, 2021 ; Stadtman et al, 2005 ; Bonifácio et al, 2021 ; Blachier et al, 2020 ; Kumar et al, 2017 ; Récher, 2021 ; Klemm and Ruland, 2006 ). The most frequently enriched KEGG pathway was “ribosome” (enriched in eight shortest paths; Figure 4A ).…”

Section: Resultsmentioning

confidence: 99%

The Inflamm-Aging Model Identifies Key Risk Factors in Atherosclerosis

Chen

Yao

et al. 2022

Front. Genet.

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Background: Atherosclerosis, one of the main threats to human life and health, is driven by abnormal inflammation (i.e., chronic inflammation or oxidative stress) during accelerated aging. Many studies have shown that inflamm-aging exerts a significant impact on the occurrence of atherosclerosis, particularly by inducing an immune homeostasis imbalance. However, the potential mechanism by which inflamm-aging induces atherosclerosis needs to be studied more thoroughly, and there is currently a lack of powerful prediction models.Methods: First, an improved inflamm-aging prediction model was constructed by integrating aging, inflammation, and disease markers with the help of machine learning methods; then, inflamm-aging scores were calculated. In addition, the causal relationship between aging and disease was identified using Mendelian randomization. A series of risk factors were also identified by causal analysis, sensitivity analysis, and network analysis.Results: Our results revealed an accelerated inflamm-aging pattern in atherosclerosis and suggested a causal relationship between inflamm-aging and atherosclerosis. Mechanisms involving inflammation, nutritional balance, vascular homeostasis, and oxidative stress were found to be driving factors of atherosclerosis in the context of inflamm-aging.Conclusion: In summary, we developed a model integrating crucial risk factors in inflamm-aging and atherosclerosis. Our computation pipeline could be used to explore potential mechanisms of related diseases.

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Stroke and Coronary Artery Disease Are Associated With Parkinson’s Disease

Abstract: Our study suggested that stroke and CAD are associated with PD in two Chinese population-based cohorts, indicating a probable vascular component in the pathogenesis of PD.

Cited by 25 publications

References 36 publications

Tinnitus and risk of Alzheimer’s and Parkinson’s disease: a retrospective nationwide population-based cohort study

Tinnitus and risk of Alzheimer’s and Parkinson’s disease: a retrospective nationwide population-based cohort study

Protective Effect of Renin-Angiotensin System Inhibitors on Parkinson’s Disease: A Nationwide Cohort Study

The Inflamm-Aging Model Identifies Key Risk Factors in Atherosclerosis

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