Stroke and depression

Sivolap, Yu P; Damulin, I V

doi:10.17116/jnevro2019119091143

Cited by 17 publications

(14 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Stroke not only damages the physical health of patients, but also affects their mental health. Stroke patients may suffer from a variety of symptoms, including cognitive decline (3), sleep disturbance (4), restricted movement (5) and depression (6). Studies have shown that stroke patients are more likely to suffer from depressive symptoms compared with the general population (7).…”

Section: Introductionmentioning

confidence: 99%

Resilience as the Mediating Factor in the Relationship Between Sleep Disturbance and Post-stroke Depression of Stroke Patients in China: A Structural Equation Modeling Analysis

et al. 2021

View full text Add to dashboard Cite

Background: Stroke patients may suffer from a variety of symptoms which can result in sleep disturbance and post-stroke depression (PSD). Whereas, resilience can alleviate sleep disturbance and help maintain well-being after stroke.Objective: The aim of this study is to explore whether resilience plays a mediating role in the relationship between sleep disturbance and PSD of stroke patients in China.Methods: A cross-sectional study with a multi-stage sampling was carried out in Liaoning Rehabilitation Center and the Third People's Hospital of Chongqing in China from May to September 2019. A total of 353 stroke patients were enrolled in this study. Structural equation model (SEM) was used to test the mediating effect of resilience on the relationship between sleep disturbance and PSD.Results: The prevalence of PSD of stroke patients was 34.56%. Sleep disturbance contributed most to the variance of PSD and had a significantly positive association with PSD among stroke patients (P < 0.01). Resilience was negatively associated with PSD, and acted as a mediator between sleep disturbance and PSD (a * b = 0.201, BCa 95% CI: 0.156~0.254).Conclusions: The prevalence of PSD was high among the Chinese stroke patients. Sleep disturbance was highly associated with PSD, resulting in the increased risk of PSD. Furthermore, resilience has a mediating effect on the relationship between sleep disturbance and PSD, and could reduce the negative effect of sleep disturbance on the development of PSD.

show abstract

Section: Introductionmentioning

confidence: 99%

Resilience as the Mediating Factor in the Relationship Between Sleep Disturbance and Post-stroke Depression of Stroke Patients in China: A Structural Equation Modeling Analysis

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Ninthly, according to the previous study, AIS patients often faced psychological issues (such as depression), which needed more attention in the further studies. 34 In conclusion, serum JKAP correlates with disease severity, Th2 and Th17 secreted cytokines, ICAM-1, and recurrence in AIS patients, indicating its potency to realize the risk stratification and consequently help clinicians provide individual treatment to each AIS patient.…”

Section: Correlation Of Jkap With Recurrence and Death Risk In Ais Pa...mentioning

confidence: 86%

Clinical value of serum JKAP in acute ischemic stroke patients

Zhang

Yang

et al. 2022

Clinical Laboratory Analysis

View full text Add to dashboard Cite

Background Jun N‐terminal kinase pathway‐associated phosphatase (JKAP) regulates neuronal function, T helper (Th) 1/2/17 cell differentiation, and inflammatory process, but its clinical role in acute ischemic stroke (AIS) patients remains unclear. Hence, this study intended to evaluate JKAP level and its relationship with disease severity, Th1, 2, 17 secreted cytokines, adhesion molecules, and prognosis of AIS patients. Methods Serum JKAP of 122 AIS patients and 50 controls was detected by ELISA. For AIS patients only, Th1, 2, 17 secreted cytokines IFN‐γ, IL‐4, IL‐17; TNF‐α, ICAM‐1, and VCAM‐1 were also detected by ELISA. Results JKAP was decreased in AIS patients compared with controls (46.350 (interquartile range (IQR): 34.250–59.875) pg/ml vs. 84.500 (IQR: 63.175–113.275) pg/ml, p < 0.001), which could distinguish AIS patients from controls (area under curve (AUC): 0.810, 95% confidence interval (CI): 0.732–0.888). In AIS patients, JKAP negatively linked with the National Institutes of Health Stroke Scale (NIHSS) score (rs = −0.342, p < 0.001); besides, it was positively related to IL‐4 (rs = 0.213, p = 0.018) and negatively associated with IL‐17 (rs = −0.270, p = 0.003) but not related to IFN‐γ (rs = −0.146, p = 0.109). Furthermore, elevated JKAP associated with declined TNF‐α (rs = −0.219, p = 0.015) and ICAM‐1 (rs = −0.235, p = 0.009) but not related to VCAM‐1 (rs = −0.156, p = 0.085). Besides, declined JKAP was linked with 2‐year recurrence (p = 0.027) and 3‐year recurrence (p = 0.010) in AIS patients; while JKAP was not related to 1‐year recurrence or death risk (both p > 0.050). Conclusion JKAP may sever as a candidate prognostic biomarker in AIS patients, indicating its potency for AIS management.

show abstract

“…45 If this is not swiftly overcome it may lead to post-stroke depression that heavily impacts patients' quality of life, as well as likely negatively influencing their chance of survival and rehabilitation. 46,47…”

Section: Stroke and Unhappinessmentioning

confidence: 99%

Happiness: A Novel Outcome Measure in Stroke?

Wijeratne

Sales

Wijeratne

et al. 2021

TCRM

View full text Add to dashboard Cite

In this narrated review, we draw attention to the use of happiness as a novel outcome measure in clinical research studies regarding patients with stroke. Commonly used outcome measures in clinical trials in stroke rehabilitation include the modified Rankin Score (mRS), Functional Impairment Measures (FIM), Barthel Index and quality of life (QoL). Despite being a part of QoL, happiness is arguably a significant construct on its own. While QoL assesses perceptions of various extrinsic aspects of life, happiness may be used as a measure of subjective enjoyment of life after an illness. We review the literature discussing the use of happiness as a formal outcome measure in stroke care and subacute and long-term stroke rehabilitation. Ultimately we recommend the wider use of happiness as an outcome measure where appropriate in these settings.

show abstract

Stroke and depression

Cited by 17 publications

References 37 publications

Resilience as the Mediating Factor in the Relationship Between Sleep Disturbance and Post-stroke Depression of Stroke Patients in China: A Structural Equation Modeling Analysis

Resilience as the Mediating Factor in the Relationship Between Sleep Disturbance and Post-stroke Depression of Stroke Patients in China: A Structural Equation Modeling Analysis

Clinical value of serum JKAP in acute ischemic stroke patients

Happiness: A Novel Outcome Measure in Stroke?

Contact Info

Product

Resources

About