Abstract:Stroke is a common cause of patient morbidity and mortality, being the fifth leading cause of death in the United States. Positron emission tomography (PET) is a proven tool for oncology patients, and may have utility in patients with stroke. We demonstrate findings of stroke incidentally detected on oncologic PET/CTs using 18F-FDG, 11C-Choline, and 68Ga-DOTATATE radiotracers. Specifically, focal 11C-Choline or 68Ga-DOTATATE uptakes localized in areas of MRI confirmed ischemia, and paradoxically increased 18F-… Show more
“…Dundar et al [ 37 ] report three cases of incidentally detected stroke in oncology scans using [ 68 Ga]Ga-DOTATATE, [ 11 C]-choline and [ 18 F]FDG tracers suggesting tracer uptake in neuroinflammation in regions of acute/subacute stroke.…”
Somatostatin receptor (SSTR) agonist tracers used in nuclear medicine scans are classically used for neuroendocrine tumor diagnosis and staging. SSTR are however, expressed more widely in a variety of cells as seen in the distribution of physiological tracer uptake during whole body scans. This provides opportunities for using these tracers for applications other than NETs and meningiomas. In this qualitative systematic review, novel diagnostics in SSTR-PET imaging are reviewed. A total of 70 studies comprised of 543 patients were qualitatively reviewed. Sarcoidosis, atherosclerosis and phosphaturic mesenchymal tumors represent the most studied applications currently with promising results. Other applications remain in progress where there are many case reports but a relative dearth of cohort studies. [18F]FDG PET provides the main comparative method in many cases but represents a well-established general PET technique that may be difficult to replace, without prospective clinical studies.
“…Dundar et al [ 37 ] report three cases of incidentally detected stroke in oncology scans using [ 68 Ga]Ga-DOTATATE, [ 11 C]-choline and [ 18 F]FDG tracers suggesting tracer uptake in neuroinflammation in regions of acute/subacute stroke.…”
Somatostatin receptor (SSTR) agonist tracers used in nuclear medicine scans are classically used for neuroendocrine tumor diagnosis and staging. SSTR are however, expressed more widely in a variety of cells as seen in the distribution of physiological tracer uptake during whole body scans. This provides opportunities for using these tracers for applications other than NETs and meningiomas. In this qualitative systematic review, novel diagnostics in SSTR-PET imaging are reviewed. A total of 70 studies comprised of 543 patients were qualitatively reviewed. Sarcoidosis, atherosclerosis and phosphaturic mesenchymal tumors represent the most studied applications currently with promising results. Other applications remain in progress where there are many case reports but a relative dearth of cohort studies. [18F]FDG PET provides the main comparative method in many cases but represents a well-established general PET technique that may be difficult to replace, without prospective clinical studies.
“…A score of 0 indicates no disorder, while 5 demonstrates a condition that indicates that care is constantly required, and a patient with 6 score is deceased. 21 The mRS scores were considered as favorable (0-2) and unfavorable (3)(4)(5)(6) outcomes. National Institute of Health stroke scale (NIHSS) scores were also used for the quantification of neurological deficit.…”
Section: Study Subjects and Blood Sample Collectionmentioning
confidence: 99%
“…The current definitive diagnosis for IS relies on invasive methods (analysis of cerebrospinal fluid), or methods that require expensive technology such as positron emission tomography (PET). 5 There remains a lack of established, sensitive, and specific non‐invasive methods such as serum biomarkers for the diagnosis and predicting the outcome of IS.…”
Stroke is one of the principal causes of adult chronic disability and is associated with high morbidity and mortality. 1 Stroke is divided into different pathological types; ischemic and hemorrhagic. 2,3 Ischemic stroke (IS) which is the most common (88% of all stroke cases), occurs when there is an occlusion in one of the cerebral arteries, 4 leading to ischemia and loss of brain function. Accordingly, rapid treatment, and improved outcomes, depend on a reliable diagnosis. The current definitive diagnosis for IS relies on invasive methods (analysis of
“…MRI-based techniques, such as MR angiography (MRA; see Glossary, Box 2 ) and diffusion-weighted imaging (DWI; Box 2 ), can provide more detailed information about a clot's size and location, and generate a clear picture of acute infarction ( Kidwell and Wintermark, 2010 ; Mortimer et al, 2013 ; Lee and Demchuk, 2015 ; Vo et al, 2015 ). The nuclear imaging technique, positron emission tomography (PET), is also being researched to assess its utility for stroke diagnosis ( Dundar et al, 2019 ). Box.…”
A stroke occurs when the blood flow to the brain is suddenly interrupted, depriving brain cells of oxygen and glucose and leading to further cell death. Neuroimaging techniques, such as computed tomography and magnetic resonance imaging, have greatly improved our ability to visualise brain structures and are routinely used to diagnose the affected vascular region of a stroke patient's brain and to inform decisions about clinical care. Currently, these multimodal imaging techniques are the backbone of the clinical management of stroke patients and have immensely improved our ability to visualise brain structures. Here, we review recent developments in the field of neuroimaging and discuss how different imaging techniques are used in the diagnosis, prognosis and treatment of stroke.
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