Stroke in adult polycystic kidney disease

Abstract

Summary:In order to assess the incidence of acute cerebrovascular events, 142 patients with adult polycystic kidney disease were retrospectively reviewed. Fourteen patients (9.8%) had 19 cerebral attacks. Six patients (4.2%) had intracranial haemorrhage attacks (three ruptured intracranial aneurysms and three cerebral haemorrhages). Ischaemic events occurred in nine patients (five cerebral infarctions and four transient ischaemic attacks). Patients with ischaemic attacks had a better outcome than patients with haemorrhagic events even when transient ischaemic attacks were excluded. Patients with ruptured intracranial aneurysms were younger. Cerebral complications are an important cause of morbidity and mortality in patients with adult polycystic kidney disease. They can prove disabling prior to or after dialysis and transplantation.

Comparison of Intracerebral Hemorrhage and Subarachnoid Hemorrhage in Patients with Autosomal-Dominant Polycystic Kidney Disease

“…SAH in our study occurred at an average age of 39 years, which is consistent with that previously reported [2,15,16]. In a study of 258 ADPKD patients with SAH, the mean age was 41 years in ADPKD cases and 53 years in non-ADPKD cases [15].…”

“…The reported incidences of SAH and ICH in ADPKD patients are similar [2,3,16]. In contrast, the incidence of ICH is usually higher than that of SAH in the general population [19].…”

“…In contrast, fewer studies have addressed the issue of ICH associated with hypertension in ADPKD patients [2,3]. A previous study has shown that hemorrhagic stroke accounted for 11% (SAH 6% and ICH 5%) of the mortality of patients with ADPKD [16].…”

“…ADPKD patients with hemorrhagic stroke have a significantly worse outcome than those with ischemic events [2]. Subarachnoid hemorrhage (SAH) and intracerebral hemorrhage (ICH) are two subtypes of hemorrhagic stroke that may cause serious complications in patients with ADPKD prior to dialysis and transplantation [2,3].…”

Clinical presentation and outcome of autosomal dominant polycystic kidney disease in Nigeria

“…[33][34][35] ICA ruptures: Rupture of aneurysms is the most serious complication in ADPKD and may account for 7% to 13% of deaths in ADPKD. 36 The average age of ICA rupture was 49.2 years in our study, higher than 41 years reported by Rivera et al 37 Only two of the subjects with ruptured ICA were diagnosed clinically. This might have been due to the sparing use of angiographic technology in our study owing to technicalities and costs.…”