Stroke in cancer patients

Nguyen, Teri; DeAngelis, Lisa M.

doi:10.1007/s11910-006-0004-0

Cited by 49 publications

(31 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A comprehensive overview concerning the various cancer-associated stroke mechanisms and the risk of chemotherapy and radiation in this context is given elsewhere. [19][20][21][22] Thromboembolic complications in patients with cancer are of special importance among these. 2,3,5,22,23 Nevertheless, this association is often underestimated, in particular in those patients who are not known to have cancer once the stroke signs and symptoms occur.…”

Section: Discussionmentioning

confidence: 99%

Stroke and Cancer

Schwarzbach

Schaefer

Ebert

et al. 2012

Stroke

227

117

View full text Add to dashboard Cite

Background and Purpose-The importance of cancer-associated hypercoagulability as a possible stroke etiology in patients with cancer has received relatively little attention to date. A recent study has suggested that cancer-associated hypercoagulation may be of special importance in the absence of conventional stroke mechanisms. Methods-We identified patients with ischemic stroke sequentially admitted to our stroke center with the additional diagnosis of active and malignant cancer from 2002 to 2011. By using our prospectively collected stroke, MRI, and laboratory data banks, the etiology and risk factors of stroke, types of cancer, deep vein thrombosis/pulmonary embolism, d-dimer levels, and diffusion-weighted imaging lesion patterns were compared to an age-and sex-matched control group. Patients with cancer with a conventional stroke etiology and patients with an unidentified and/or cancer-associated stroke etiology were analyzed separately. Results-One hundred forty patients with cancer and 140 control subjects were included. Unidentified stroke (P<0.001) and infarction in multiple vascular territories (P<0.001) were significantly more frequent and d-dimer levels significantly higher (P<0.05) in patients with cancer. Vice versa, risk factors such as hypertension (P<0.05) and hyperlipidemia (P<0.01) were more prevalent in control subjects. Deep vein thrombosis and pulmonary embolism were more frequent (P<0.01) and d-dimer levels higher (P<0.01) in the patients with unidentified and/or cancerassociated stroke etiology compared to the patients with cancer with a conventional stroke etiology. Lung and pancreatic cancer were significantly overrepresented and d-dimer levels higher in these patients compared with other patients with cancer (P<0.01). Conclusions-Our data confirm the concept of cancer-associated hypercoagulation as a widely underestimated important stroke risk factor in patients with cancer, especially in those with severely elevated

show abstract

Section: Discussionmentioning

confidence: 99%

Stroke and Cancer

Schwarzbach

Schaefer

Ebert

et al. 2012

Stroke

227

117

View full text Add to dashboard Cite

show abstract

“…It can be therapy related and be the result of extensive radiation (e.g. RT of the neuraxis), chemotherapy or polychemotherapy (3,8,66).…”

Section: Miscellaneousmentioning

confidence: 99%

“…In this study, the risk of recurrent ischaemic events was also similar to that of the non-cancer population. Recent articles compare cancer patients with a non-cancer population by means of image-based classifications and common risk factors for stroke (7)(8)(9)(10)(11). Concerning the studies, they all suffer from referral bias, which is less marked in general hospitals than in cancer centres.…”

Section: Introductionmentioning

confidence: 99%

Stroke and cancer: a review

Grisold¹,

Oberndorfer²,

Struhal³

2009

Acta Neurologica Scandinavica

210

175

View full text Add to dashboard Cite

“…While a transesophageal echocardiogram would have been more sensitive for cardioembolic sources, and particularly for nonbacterial thrombotic endocarditis (NBTE), patients with primary brain tumors do not seem to be at high risk for NBTE, as do patients with systemic cancers. 3 In addition, the stepwise extension of the stroke area, at a 2-month interval, favors a local progressive mechanism. The large vessel ischemic stroke was therefore attributed to a direct effect of the tumor on the MCA.…”

mentioning

confidence: 99%