Stroke in sickle cell anemia patients: A need for multidisciplinary approaches

Menaa, Farid

doi:10.1016/j.atherosclerosis.2013.05.006

Cited by 21 publications

(24 citation statements)

References 97 publications

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“…For the success of clinical application of NSCs, a scaffold is required to provide 3D cell‐growth microenvironments and appropriate synergistic cell‐guidance cues, and so, in this context, 3D graphene foams (3D‐GFs) (Figure B) would be a better option than 2D‐GFs (Figure A) or 2D‐G derivatives, such as GO (Figure ) (Li et al , ). Besides, transplantation of biomaterial scaffolds encasing either human ESCs (Baharvand et al , ; Jin et al , ; Chen et al , ; Menaa, ) or adult SCs (Delcroix et al , ; Menaa, ) has been proposed as a clinical therapy for various neurological lesions and disorders, such as spinal cord injury, cerebral ischaemia and stroke. Eventually, iPSCs hold great promise as a cell source for RM; however their culture, maintenance of pluripotency and induction of differentiation remain challenging (Chen et al , ).…”

Section: Graphene‐based Biomaterials: New Scaffolds For Tissue Enginementioning

confidence: 99%

“…Besides, in order to improve the biocompatibility properties, such as minimal blood transfusion toxicity of expanded haematopoietic SCs (HSCs) (Shahrokhi et al , ; Menaa, ; Bari et al , ) and/or mechanical strength for uses as scaffolds, e.g. for bone regeneration (Tran et al , ), CNTs can be functionalized with different side‐groups by two main methods (Zhao et al , ; Shi et al , ; Shin et al , ): (a) poly( m ‐aminobenzene) sulphonic acid (PABS); the negatively charged groups of PABS lead to amidation of the carboxylic acid groups (–COOH) on CNTs and attract calcium cations for mineralization, i.e.…”

Section: Graphene‐based Biomaterials: New Scaffolds For Tissue Enginementioning

confidence: 99%

“…cancers such as leukaemia) and non‐malignant (e.g. haemoglobinopathies such as sickle cell anaemia) diseases (Shahrokhi et al , ; Menaa, ; Bari et al , ). Indeed, in a very recent study, carboxylic acid‐functionalized SWNTs (f‐SWNTs‐COOH) were shown to support the viability and enhance the expansion of freeze‐thawed, non‐enriched haematopoietic stem and progenitor cells (HSPCs) in human umbilical cord blood‐mononucleated cells (UCB‐MNCs) (Bari et al , ).…”

Section: Graphene‐based Biomaterials: New Scaffolds For Tissue Enginementioning

confidence: 99%

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Graphene nanomaterials as biocompatible and conductive scaffolds for stem cells: impact for tissue engineering and regenerative medicine

Menaa

Abdelghani

Menaa

2014

J Tissue Eng Regen Med

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151

112

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The discovery of the interesting intrinsic properties of graphene, a two-dimensional nanomaterial, has boosted further research and development for various types of applications from electronics to biomedicine. During the last decade, graphene and several graphene-derived materials, such as graphene oxide, carbon nanotubes, activated charcoal composite, fluorinated graphenes and three-dimensional graphene foams, have been extensively explored as components of biosensors or theranostics, or to remotely control cell-substrate interfaces, because of their remarkable electro-conductivity. To date, despite the intensive progress in human stem cell research, only a few attempts to use carbon nanotechnology in the stem cell field have been reported. Interestingly, most of the recent in vitro studies indicate that graphene-based nanomaterials (i.e. mainly graphene, graphene oxide and carbon nanotubes) promote stem cell adhesion, growth, expansion and differentiation. Although cell viability in vitro is not affected, their potential nanocytoxicity (i.e. nanocompatibility and consequences of uncontrolled nanobiodegradability) in a clinical setting using humans remains unknown. Therefore, rigorous internationally standardized clinical studies in humans that would aim to assess their nanotoxicology are requested. In this paper we report and discuss the recent and pertinent findings about graphene and derivatives as valuable nanomaterials for stem cell research (i.e. culture, maintenance and differentiation) and tissue engineering, as well as for regenerative, translational and personalized medicine (e.g. bone reconstruction, neural regeneration). Also, from scarce nanotoxicological data, we also highlight the importance of functionalizing graphene-based nanomaterials to minimize the cytotoxic effects, as well as other critical safety parameters that remain important to take into consideration when developing nanobionanomaterials.

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Section: Graphene‐based Biomaterials: New Scaffolds For Tissue Enginementioning

confidence: 99%

Section: Graphene‐based Biomaterials: New Scaffolds For Tissue Enginementioning

confidence: 99%

Section: Graphene‐based Biomaterials: New Scaffolds For Tissue Enginementioning

confidence: 99%

See 1 more Smart Citation

Graphene nanomaterials as biocompatible and conductive scaffolds for stem cells: impact for tissue engineering and regenerative medicine

Menaa

Abdelghani

Menaa

2014

J Tissue Eng Regen Med

Self Cite

151

112

View full text Add to dashboard Cite

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“…It affects 3% to 17% of all patients with SCD, the prevalence is 11% in patients under 20 years of age, with a high recurrence rate. Most cases are ischemic, however, hemorrhagic strokes account for 13% with higher prevalence between 20 and 30 years of age and a substantial higher mortality comparing to ischemic strokes 1,2 . Several risk factors are identified 1,3 , among them: low oxygen blood content, vasculopathy, acute infection, recent acute chest syndrome, classical vascular risk factors (hypertension, diabetes, dyslipidemia), previous stroke or a rapid elevation of hemoglobin.…”

Section: Introductionmentioning

confidence: 99%

Multiple hematoma in young patient with sickle cell disease

Gordinho¹,

Rosado²,

Soares³

et al. 2018

Gal. Clin.

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Stroke remains one of the most serious complications of sickle cell disease. Almost 11% of the patients will have a stroke before the age of 20. The etiology is hemorrhagic in a small part of the cases, which is associated with a high mortality. We present the case of a 19 year-old patient, with sickle cell disease and multiple associated complications. The patient was admitted with acute chest syndrome and developed a hemorrhagic stroke while hospitalized.

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“…After its discovery as a genetically inherited hemoglobinopathy one hundred years ago, finding a widely available cure for sickle cell anemia (SCA, HbSS) still remains a challenge and the disease requires multi-disciplinary theranostic approaches (Menaa et al, 2013;Menaa, 2014). Indeed, more effort and resources to promptly find alternative therapeutics and/or adjuvants (e.g.…”

Section: Editorialmentioning

confidence: 99%

Stroke in sickle cell anemia patients: A need for multidisciplinary approaches

Cited by 21 publications

References 97 publications

Graphene nanomaterials as biocompatible and conductive scaffolds for stem cells: impact for tissue engineering and regenerative medicine

Graphene nanomaterials as biocompatible and conductive scaffolds for stem cells: impact for tissue engineering and regenerative medicine

Multiple hematoma in young patient with sickle cell disease

Supplementation of Vitamin D in Patients with Sickle Cell Bone Disease: A Dbate or a Combate?

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