Stroke in Women: Disparities and Outcomes

Persky, Rebecca; Turtzo, L. Christine; McCullough, Louise D.

doi:10.1007/s11886-009-0080-2

Cited by 191 publications

(159 citation statements)

References 53 publications

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“…OVX mice are frequently used as a model of post-menopausal women whom remain at higher risk of stroke and poor outcomes [5]. We reported that non-OVX young females are comparatively resistant to embolic stroke injury, which is lost after ovariectomy [10].…”

Section: Introductionmentioning

confidence: 99%

Remote Ischemic Perconditioning is Effective After Embolic Stroke in Ovariectomized Female Mice

Hoda

Bhatia

Hafez

et al. 2014

Transl. Stroke Res.

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Remote ischemic conditioning is neuroprotective in young male rodents after experimental stroke. However, it has never been tested in females whom remain at higher risk of stroke injury after menopause. We tested remote ischemic perconditioning therapy (RIPerC) at 2 h after embolic stroke in ovariectomized (OVX) female mice with and without intravenous tissue plasminogen activator (IV-tPA) treatment. We assessed cerebral blood flow (CBF), neurobehavioral outcomes, infarction, hemorrhage, edema, and survival. RIPerC therapy with and without IV-tPA improved the CBF and neurobehavioral outcomes and reduced the infarction, hemorrhage, and edema significantly. Late IV-tPA alone at 4 h post-stroke neither improved the neurobehavior nor reduced the infarction but aggravated hemorrhage and mortality in OVX mice. RIPerC therapy prevented the increased mortality during late IV-tPA. Our study demonstrates for the first time that RIPerC therapy is effective in OVX females.

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Section: Introductionmentioning

confidence: 99%

Remote Ischemic Perconditioning is Effective After Embolic Stroke in Ovariectomized Female Mice

Hoda

Bhatia

Hafez

et al. 2014

Transl. Stroke Res.

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“…Of these, 5.5 million die (including 3 million women and 2.5 million men) and another 5 million are left permanently disabled, placing a burden on family and community (Mackay and Mensah 2004). Women differ from men in stroke symptoms, subtypes, and risk factors (Beal 2010;Persky et al 2010;Wassertheil-Smoller 2010). In addition to common cardiovascular risk factors, for instance, hypertension and hyperlipidemia, women are confronted with such unique risk factors as oral contraceptive use.…”

Section: Introductionmentioning

confidence: 99%

Increased risk of stroke in oral contraceptive users carried replicated genetic variants: a population-based case–control study in China

Chün

Liu

et al. 2012

Hum Genet

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Combined oral contraceptives (COC) use is a unique risk factor for stroke in women, and may modify the associations between genetic polymorphisms and stroke. To investigate whether the genetic variants identified in a recent genome-wide association study (GWAS) could be replicated in Chinese women, as well as, whether related risk was different in COC users, 451 stroke cases and 831 age- and region-matched controls were recruited from our cohort. Genotyping of 3 SNPs (rs700651, rs10958409, and rs1333040) was performed by the polymerase chain reaction assay with TaqMan probes. The history of contraceptive use and relevant information were obtained from a face-to-face interview. Odds ratios (OR) with 95 % confidence interval (CI) were estimated under conditional logistic regression model after adjustment for cardiovascular covariates. Our study replicated the associations of rs10958409 and rs1333040, with the risk of stroke, especially hemorrhagic subtype, but failed to confirm association of rs700651. COC use was associated with a 1.56-fold (OR 1.56, 95 % CI 1.21-2.01) increased risk of stroke. COC users with rs10958409 GA/AA or rs1333040 CT/TT genotypes had an increased risk of overall stroke by 1.59-fold (OR 2.59, 95 % CI 1.59-4.19) and 3.24-fold (OR 4.24, 95 % CI 1.71-10.49), respectively, compared with the non-users with wild-type genotypes. Moreover, the risk of hemorrhagic stroke increased by 4.81- and 15.06-fold when risk allele carriers of rs10958409 or rs1333040 who took COC. Our results confirmed the associations of two GWAS SNPs, also suggested combination effects of these genetic variants and COC use on stroke risk.

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“…The incidence of multiple sclerosis is greater in women [6] , who, however, show a more benign course of the disease [7] . Differences between sexes in stroke incidence, prevalence, mortality and outcomes are also well known [8] .…”

Section: Introductionmentioning

confidence: 99%

Impact of Gender Differences on the Outcome of Alzheimer’s Disease

Sinforiani

Citterio

Zucchella

et al. 2010

Dement Geriatr Cogn Disord

101

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Background and Aims: Since little is known about the role of gender in the course of Alzheimer’s disease (AD), a prospective epidemiological study was conducted to detect gender differences in relation to AD evolution and outcome. Methods: Six hundred AD patients, 214 men and 386 women, first seen between September 2000 and December 2003, were enrolled; the follow-up period lasted until December 2008. Results: The men had greater comorbidity and higher mortality than the women, who instead recorded more disability and longer survival. Survival curves showed that women reach partial loss of autonomy faster than men. Higher Neuropsychiatric Inventory scores at baseline showed a predictive value for loss of autonomy regardless of gender. Pharmacological treatment seems to have a protective role on disability and mortality. Conclusions: Gender influences disease evolution not only directly but also through other factors such as comorbidity.

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Stroke in Women: Disparities and Outcomes

Cited by 191 publications

References 53 publications

Remote Ischemic Perconditioning is Effective After Embolic Stroke in Ovariectomized Female Mice

Remote Ischemic Perconditioning is Effective After Embolic Stroke in Ovariectomized Female Mice

Increased risk of stroke in oral contraceptive users carried replicated genetic variants: a population-based case–control study in China

Impact of Gender Differences on the Outcome of Alzheimer’s Disease

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