Stroke prognosis in diabetes mellitus: new insights but questions remain

Effectiveness and safety of rivaroxaban vs warfarin in people with non‐valvular atrial fibrillation and diabetes: an administrative claims database analysis

“…Globally, an estimated 422 million adults are living with diabetes . The incidence of non‐valvular atrial fibrillation in people with diabetes has been estimated to be ~15%, and these individuals have an ~1.7‐fold increased risk of stroke (vs people without diabetes) and often experience worse post‐stroke function recovery and outcomes . Hypercoagulability in people with diabetes may partly be explained by increased tissue plasminogen activator antigen levels and factor VIII activity, as well as the decreased fibrin breakdown .…”

“…Diabetes is a common comorbidity in people with nonvalvular atrial fibrillation that increases their risk of strokẽ 1.7-fold. It has also been suggested that diabetes-related strokes are associated with worse function recovery and outcomes [1,2]. In the Rivaroxaban Once-daily, Oral, Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism (ROCKET AF) trial [3], nearly 5700 patients (or~40% of the trial population) had concomitant diabetes; and in these people with diabetes, the efficacy and safety of rivaroxaban relative to warfarin appeared similar to those in the overall trial population [3,4].…”

White matter fractional anisotropy is related to processing speed in metabolic syndrome patients: a case-control study

“…Some authors have suggested this relationship between vascular risk factors and pathological pathways such as ischemic cerebral small-vessel disease, as well as a toxic effect on neurons caused by the accumulation of advanced glycation end products and their influence on neurodegenerative mechanisms. Therefore, vascular risk factors included in MetSd may influence both cerebrovascular pathology and neurodegenerative processes [ 42 ].…”

A pilot study of the effects of non-invasive mechanical ventilation on the prognosis of ischemic cerebrovascular events in patients with obstructive sleep apnea syndrome

“…The stroke patients with DM and/or AF were shown to have more severe strokes and a worse prognosis [23,24]. On the other hand, the worsening effect of DM was attributed to the diffuse endothelial dysfunction in the cerebral arterioles, especially in lacunar infarctions [23]. The stroke patients with lacunar infarction were not included in our study, but only large-vessel infarctions of atherothrombotic or cardioembolic origin to have a rather homogenous study population.…”

“…These clinical aspects might have negatively influenced the worse clinical outcome in the control group. The stroke patients with DM and/or AF were shown to have more severe strokes and a worse prognosis [23,24]. On the other hand, the worsening effect of DM was attributed to the diffuse endothelial dysfunction in the cerebral arterioles, especially in lacunar infarctions [23].…”