Stroke risk factor, pattern and outcome in patients with cancer

Zhang, Y.-Y.; Chan, Daniel Kam Yin; Cordato, Dennis; Shen, Qingyu; Sheng, Ai Zhen

doi:10.1111/j.1600-0404.2006.00709.x

Cited by 89 publications

(84 citation statements)

References 17 publications

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“…25 The prestroke cancer figure is slightly larger than that found in an older patient population with ischemic stroke. 10 Our results are also in line with a recent study that included also benign and unspecific neoplasms in their analysis. 26 The median time from cancer detection to ischemic stroke was 4.9 years, which is in the same order of magnitude as in a study from Norway, where it was 6.8 years.…”

Section: Discussionsupporting

confidence: 82%

“…8,9 Cancer patients have a higher in-hospital poststroke mortality rate than those without cancer. 10 Cancer patients with cryptogenic stroke have higher D-dimer levels and more frequently infarcts located in multiple vascular territories than patients with stroke associated with other pathogenesis. [11][12][13] The frequency of traditional ischemic stroke risk factors among cancer patients differs between studies.…”

mentioning

confidence: 99%

“…[11][12][13] The frequency of traditional ischemic stroke risk factors among cancer patients differs between studies. 10,13 Little is known about cancer among young and middle-aged patients with ischemic stroke. [14][15][16] Young patients traditionally have more ischemic strokes with nonconventional stroke mechanisms and undetermined pathogenesis compared with older stroke patients.…”

mentioning

confidence: 99%

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Cancer in Young Adults With Ischemic Stroke

Aarnio

Joensuu

Haapaniemi

et al. 2015

Stroke

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Background and Purpose— Cancer is a risk factor for ischemic stroke. Little is known about cancer among young adults with ischemic stroke. We studied the frequency of cancer and its association with long-term risk of death among young patients with first-ever ischemic stroke. Methods— 1002 patients aged 15 to 49 years, registered in the Helsinki Young Stroke Registry, and with a median follow-up of 10.0 years (interquartile range 6.5–13.8) after stroke were included. Historical and follow-up data were derived from the Finnish Care Register and Statistics Finland. Survival between groups was compared with the Kaplan–Meier life-table method, and Cox proportional hazard models were used to identify factors associated with mortality. Results— One or more cancer diagnosis was made in 77 (7.7%) patients, of whom 39 (3.9%) had cancer diagnosed prestroke. During the poststroke follow-up, 41 (53.2%) of the cancer patients died. Median time from prestroke cancer to stroke was 4.9 (1.0–9.5) years and from stroke to poststroke cancer was 6.7 (2.7–10.9) years. Poststroke cancer was associated with age >40 years, heavy drinking, and cigarette smoking. The cumulative mortality was significantly higher among the cancer patients (68.6%, 95% confidence interval 52.0%–85.3%) compared with patients without cancer (19.7%, 95% confidence interval 16.3%–23.2%). Active cancer at index stroke, melanoma, and lung/respiratory tract cancer had the strongest independent association with death during the follow-up when adjusted for known poststroke mortality prognosticators. Conclusions— Cancer, and especially active cancer and no other apparent cause for stroke, is associated with unfavorable survival among young stroke patients.

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Section: Discussionsupporting

confidence: 82%

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confidence: 99%

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confidence: 99%

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Cancer in Young Adults With Ischemic Stroke

Aarnio

Joensuu

Haapaniemi

et al. 2015

Stroke

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“…It is commonly mentioned in the literature that heparin is the preferred treatment (2,(10)(11)(12)(13)(14)(15). In recent years, low-molecular-weight heparins have become popular, in part due to their improved pharmacokinetics, the ability to administer single daily dosages, and the reduced incidence of heparin-induced thrombocytopenia (16)(17)(18).…”

Section: Discussionmentioning

confidence: 99%

Case series of cerebral infarction with Trousseau's syndrome associated with malignant gynecological tumors

Ishikawa

Nakayama

Ishibashi

et al. 2016

Molecular and Clinical Oncology

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Abstract. The association between neoplastic disease and thromboembolic disorders was first recognized by Trousseau in 1865. Blood coagulation abnormalities have been reported in the majority of patients with cancer, including those with ovarian carcinoma. However, Trousseau's syndrome (TS) has rarely been reported in women with ovarian carcinoma. We herein report a case series of TS, notably in the brain, in association with gynecological malignant disease, and emphasize the difficulties associated with the management of these thromboembolic effects. The aim of this study was to present our experience with 5 TS patients whose condition was effectively controlled through treatment of the primary malignant disease. Therefore, we suggest that patients with TS may be cured by tumor resection, even if they have severe thromboembolic disease, such as cerebral or pulmonary infarction.

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“…Specifically, cancer-related mechanisms such as coagulopathy and tumour occlusion are a common cause of IS in patients with cancer [10][11][12][13][14]. In addition, treatment modalities such as chemotherapy, radiotherapy, and hormone therapy may also increase the risk of IS [13][14][15]. However, little is known regarding the causes and outcomes of IS in critically ill patients with cancer.…”

Section: Introductionmentioning

confidence: 99%