Stroke Risk in Atrial Fibrillation: Beyond the CHA2DS2-VASc Score

Jagadish, Pooja S.; Kabra, Rajesh

doi:10.1007/s11886-019-1189-6

Cited by 31 publications

(30 citation statements)

References 59 publications

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“…Более сложные шкалы оценки риска смерти, например, шкала GARFIELD-AF, статистически точнее прогнозирует смертность от всех причин и является в этом вопросе приоритетнее шкалы CHA 2 DS 2 -VASc. В дальнейшем она может быть внедрена в электронную базу данных для расчета риска развития инсульта, смерти от всех причин и клинически значимого кровотечения [11]. Одна из шкал оценки рисков ОБЗОРЫ § смерти -АВС-death -имеет уровень прогностического индекса (с-индекс) 0,74 (95 % ДИ от 0,72 до 0,76), тогда как с-индекс для CHA 2 DS 2 -VASc равен 0,58 (95 % ДИ от 0,56 до 0,61).…”

Section: сочетанные заболевания при фибрилляции предсердий и их влиянunclassified

Atrial Fibrillation and Mortality: Prognostic Factors and Direction of Prevention

et al. 2021

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This review focuses on major causes and risk factors for death of patients with atrial fibrillation (AF). The authors analyzed current therapeutic strategies for managing patients with AF with respect of their effects on prediction and mortality. Special attention is paid to the strategy of rhythm control and the clinical significance of catheter ablation in the treatment of patients with AF and heart failure.

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Section: сочетанные заболевания при фибрилляции предсердий и их влиянunclassified

Atrial Fibrillation and Mortality: Prognostic Factors and Direction of Prevention

et al. 2021

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“…CHADS 2 and CHA 2 DS 2 -VASc scores are practical tools for evaluating the prognosis of stroke patients [10]. However, these above-mentioned two scoring systems do not take into account other potential risk factors, such as renal function impairment, rheumatoid arthritis, obesity or smoking, nor do they consider clinically accessible laboratory indicators, imaging values and other parameters [11,12]. Friberg et al [13] have shown that clinically diagnosed heart failure does not increase rates of stroke in AF patients.…”

Section: Introductionmentioning

confidence: 99%

LDL-C/HDL-C is associated with ischaemic stroke in patients with non-valvular atrial fibrillation: a case-control study

et al. 2020

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Background This study explored the relationships between the low−/high-density lipoprotein cholesterol ratio (LDL-C/HDL-C) and other clinical indicators and ischaemic stroke (IS) in patients with non-valvular atrial fibrillation (NVAF) in Xinjiang. The findings could provide a theoretical and therapeutic basis for NVAF patients. Methods NVAF patients who were admitted to 10 medical centres across Xinjiang were divided into stroke (798 patients) and control (2671 patients) groups according to the occurrence of first acute IS. Univariate and multivariate logistic regression analysis were used to examine the independent risk factors for IS in NVAF patients. Factor analysis and principal component regression analysis were used to analyse the main factors influencing IS. Receiver operating characteristic (ROC) curve analysis was used to evaluate the discriminatory ability of LDL-C/HDL-C for predicting the occurrence of IS. Results The stroke group had an average age of 71.64 ± 9.96 years and included 305 females (38.22%). The control group had a mean age of 67.30 ± 12.01 years and included 825 females (30.89%). Multivariate logistic regression showed that the risk of IS in the highest LDL-C/HDL-C quartile (≥2.73) was 16.23-fold that of the lowest quartile (< 1.22); IS risk was 2.27-fold higher in obese patients than in normal-weight subjects; IS risk was 3.15-fold higher in smoking patients than in non-smoking patients. The area under the ROC curve of LDL-C/HDL-C was 0.76, the optimal critical value was 2.33, the sensitivity was 63.53%, and the specificity was 76.34%. Principal component regression analysis showed that LDL-C/HDL-C, age, smoking, drinking, LDL-C and hypertension were risk factors for IS in NVAF patients. Conclusions LDL-C/HDL-C > 1.22, smoking, BMI ≥24 kg/m2 and CHA2DS2-VASc score were independent risk factors for IS in NVAF patients; LDL-C/HDL-C was the main risk factor.

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“…Warfarin or non-vitamin K antagonist oral anticoagulants (NOACs) are recommended for patients at high risk of stroke. However, the abovementioned two scoring systems do not take into account other potential risk factors, such as renal function impairment, rheumatoid arthritis, obesity or smoking, as well as clinically accessible laboratory indicators, imaging values and other parameters [4,5]. Friberg et al [6] have shown that clinically diagnosed heart failure is not an independent risk factor for stroke in AF patients.…”

Section: Introductionmentioning

confidence: 99%

LDL-C/HDL-C is Associated With Ischaemic Stroke in Patients With Non-Valvular Atrial Fibrillation: A Case-Control Study

Zhang

Meng

Shang

et al. 2020

Preprint

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Background This study explored relationships between low-/high-density lipoprotein cholesterol ratio (LDL-C/HDL-C) and other clinical indicators and ischaemic stroke (IS) in non-valvular atrial fibrillation (NVAF) patients in Xinjiang, which could provide a theoretical and therapeutic basis for patients with NVAF. Methods NVAF patients who were admitted to 10 medical centres across Xinjiang were divided into the stroke (798 patients) and control (2671 patients) groups according to whether acute IS occurred. Univariate and multivariate logistic regression analysis was used to examine the independent risk factors for IS in NVAF patients. We used factor analysis and principal component regression analysis to analyse the main influencing factors of IS. Receiver operating characteristic (ROC) curve analysis was used to evaluate the optimal cut-off value of LDL-C/HDL-C in predicting IS. Results Multivariate logistic regression showed that the risk of IS in the highest quartile of LDL-C/HDL-C (≥ 2.73) was 16.23-fold that in the lowest quartile (< 1.22); IS risk was 2.27-fold higher in obese patients (BMI ≥ 28 kg/m2) than in normal-weight subjects; IS risk was 3.15-fold higher in smoking than in non-smoking patients. The area under the ROC curve of LDL-C/HDL-C was 0.76, optimal critical value was 2.33, sensitivity was 63.53%, and specificity was 76.34%. Principal component regression analysis showed that LDL-C/HDL-C, age, smoking, drinking, LDL-C and hypertension were risk factors for IS in NVAF patients. Conclusions LDL-C/HDL-C > 1.22, smoking and BMI ≥ 24 kg/m2 were independent risk factors for IS in NVAF patients, of which LDL-C/HDL-C was the main risk factor.

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Stroke Risk in Atrial Fibrillation: Beyond the CHA2DS2-VASc Score

Cited by 31 publications

References 59 publications

Atrial Fibrillation and Mortality: Prognostic Factors and Direction of Prevention

Atrial Fibrillation and Mortality: Prognostic Factors and Direction of Prevention

LDL-C/HDL-C is associated with ischaemic stroke in patients with non-valvular atrial fibrillation: a case-control study

LDL-C/HDL-C is Associated With Ischaemic Stroke in Patients With Non-Valvular Atrial Fibrillation: A Case-Control Study

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