“…The definition of VaD and vascular cognitive impairment (VCI) has evolved over time [ 34 , 62 , 63 , 64 , 65 , 66 ], though overall requires that the cognitive impairment be temporally related to strokes or be accompanied by significant neuroimaging evidence of cerebrovascular disease. PwMS have an increased risk of stroke [ 67 , 68 ], and would thus be more susceptible to developing VCI in addition to MS-related cognitive decline. Among the subtypes of vascular dementia, subcortical vascular dementia due to small-vessel disease [ 69 ] can present with progressive fronto-subcortical dysfunction (e.g., slowed psychomotor speed, impaired executive function, and impaired memory recall, but preserved recognition), similar to subcortical dementia as a result of MS [ 70 ].…”