Stroke risks and patterns of warfarin therapy among atrial fibrillation patients post radiofrequency ablation

Zhang, Juan; Liu, Xingpeng; Liu, Xiaoqing; Yin, Xiandong; Wang, Yanjiang; Lü, Xiaoying; Yang, Xinchun

doi:10.1097/md.0000000000008762

Cited by 1 publication

(1 citation statement)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, in a number of cases recurrence of arrhythmias occurs 3 . In addition, complications as for instance, an increased stroke risk, bechance 4 . Recently, initial clinical tests of stereotactic X-ray therapy have been successfully performed in patients affected by ventricular tachycardia 5 .…”

Section: Introductionmentioning

confidence: 99%

Biological Cardiac Tissue Effects of High-Energy Heavy Ions – Investigation for Myocardial Ablation

Rapp

Simoniello

Wiedemann

et al. 2019

Sci Rep

View full text Add to dashboard Cite

Noninvasive X-ray stereotactic treatment is considered a promising alternative to catheter ablation in patients affected by severe heart arrhythmia. High-energy heavy ions can deliver high radiation doses in small targets with reduced damage to the normal tissue compared to conventional X-rays. For this reason, charged particle therapy, widely used in oncology, can be a powerful tool for radiosurgery in cardiac diseases. We have recently performed a feasibility study in a swine model using high doses of high-energy C-ions to target specific cardiac structures. Interruption of cardiac conduction was observed in some animals. Here we report the biological effects measured in the pig heart tissue of the same animals six months after the treatment. Immunohistological analysis of the target tissue showed (1.) long-lasting vascular damage, i.e. persistent hemorrhage, loss of microvessels, and occurrence of siderophages, (2.) fibrosis and (3.) loss of polarity of targeted cardiomyocytes and wavy fibers with vacuolization. We conclude that the observed physiological changes in heart function are produced by radiation-induced fibrosis and cardiomyocyte functional inactivation. No effects were observed in the normal tissue traversed by the particle beam, suggesting that charged particles have the potential to produce ablation of specific heart targets with minimal side effects.

show abstract

Section: Introductionmentioning

confidence: 99%