Stroma in normal and cancer wound healing

Huet, Eric; Jaroz, Camille; Nguyen, Hoang Q.; Belkacémi, Yazid; Taille, Alexandre de la; Stavrinides, Vasilis; Whitaker, Hayley C.

doi:10.1111/febs.14842

Cited by 33 publications

(20 citation statements)

References 90 publications

(120 reference statements)

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“…CD147 forms complexes with α3β1 and α6β1 integrins by cell-cell contact, which in turn promotes tumor invasion by inducing matrix metalloproteinase (MMP) synthesis via a focal adhesion kinase-(FAK-) PI3K signaling pathway [22]. In addition, CD147 is an inducer of extracellular MMP and suggested to play an important role in cell differentiation due to developmental defects observed in the knockout mice [23][24][25][26]. ese include active differentiation of basal cells in the epithelium, which show a strong and constitutive expression of CD147, whereas a weak expression in the superficial terminally differentiated cells [27].…”

Section: Discussionmentioning

confidence: 99%

CD147 Expression Is Associated with Tumor Proliferation in Bladder Cancer via GSDMD

Peng

Jiang

Guo

et al. 2020

BioMed Research International

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Purpose. CD147, also known as BSG, is a type I transmembrane glycoprotein that belonged to immunoglobulin superfamily. Mature CD147 is an N-linked glycosylated protein and exists on the transmembrane and as soluble forms in tumors. However, the function of CD147 in cell proliferation of bladder cancer (BC) remains to be elucidated. Methods. e study included 159 patients with BC and 68 healthy controls. e expression of CD147 and gasdermin D (GSDMD) was analyzed by immunohistochemistry (IHC). Western blotting was performed to detect the expression of proteins in BC cells. e relationship between CD147 and GSDMD was analyzed by the IHC score. Results. e expression of CD147 was significantly increased in BC when compared to healthy controls, and the level of CD147 was correlated with tumor proliferation characterized by Ki-67, which is a cell proliferation antigen. In addition, CD147 treatment of BC cells increased the expression of GSDMD, leading to increased Ki-67 expression, while CD147 blockade with peptide in BC significantly reduced GSDMD expression, resulting in reduced cell proliferation. Furthermore, overexpression of GSDMD markedly overcame the inhibitory effect of CD147 peptide on tumor proliferation. BC patients with overexpression of CD147 showed correlation with GSDMD and demonstrated significantly poorer prognosis and overall survival rate. Conclusion. ese findings suggested that high expression of CD147 contributed to tumor proliferation in BC via GSDMD, which might in turn act as an unfavorable prognostic marker.

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Section: Discussionmentioning

confidence: 99%

CD147 Expression Is Associated with Tumor Proliferation in Bladder Cancer via GSDMD

Peng

Jiang

Guo

et al. 2020

BioMed Research International

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“…A recent systematic review and meta‐analysis showed a negative correlation between CAFs and a poor prognosis of OSCC patients (Dourado, Guerra, Salo, Lambert, & Coletta, ). CAFs, one of the most dominant components of cancer microenvironment at all stages of progression, are analogues to "factories" that produce a large diversity of molecular factors that reinforce tumor cell proliferation, remodel the structure of the extracellular matrix, alter the metabolic properties of the tumor cells, reprogram the anti‐tumor immune response, facilitate the metastatic process, and define resistance to therapy (Huet et al, ; Kalluri, ).…”

Section: Introductionmentioning

confidence: 99%

Oral cancer‐associated fibroblasts predict poor survival: Systematic review and meta‐analysis

et al. 2019

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Objectives To perform systematic review and meta‐analysis on correlations between cancer‐associated fibroblasts (CAFs) and the risk of death for patients with oral squamous cell carcinoma. Subjects and methods English literature (1966–2018) was systematically analyzed for studies that immunohistochemically assessed CAF density by alpha‐smooth muscle actin and presented 5 year survival rates by Kaplan–Meier plots. Mean age of patients, proportion of male/female patients, and male/female majority (>50% male/female patients) per study were also collected. Significance level for statistical models was p < 0.05. Results Meta‐analysis comprised 11 studies/1,040 patients. Univariate Cox regressions showed that high CAF density was a negative prognostic factor in studies with female and male majority [OR 5.329 (95% CI 3.223–8.811), p < 0.001, and OR 2.208 (95% CI 1.717–2.839), p < 0.001, respectively]. High CAF density with male majority was associated with a more favorable prognosis [OR 0.996 (95% CI 0.979–1.013), p < 0.001]. Multivariate Cox regressions showed that death risk was significantly higher among patients with high CAF density compared to low CAF [OR 2.741 (95% CI 2.220–3.384) p < 0.001]. High mean age and male proportion were significantly protective [OR 0.940 (95% CI 0.925–9.955), p < 0.001, OR 0.125 (95% CI 0.018–0.867), p = 0.035), respectively]. Conclusions CAFs increased death risk, male majority, and higher mean age were protective. A clinically validated cutoff for CAF density could serve as a reliable prognostic tool.

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“…It is usually composed of connective tissue, the most abundant type of tissue in the body. It connects and supports other tissues and also plays a crucial role in organ development, homeostasis maintenance, and pathologies [4]. The connective tissue consists of cells, mainly fibroblasts, and ECM proteins.…”

Section: Stroma and Tumor Microenvironmentmentioning

confidence: 99%

Human Organ-Specific 3D Cancer Models Produced by the Stromal Self-Assembly Method of Tissue Engineering for the Study of Solid Tumors

Roy

Magne

Vaillancourt-Audet

et al. 2020

BioMed Research International

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Cancer research has considerably progressed with the improvement of in vitro study models, helping to understand the key role of the tumor microenvironment in cancer development and progression. Over the last few years, complex 3D human cell culture systems have gained much popularity over in vivo models, as they accurately mimic the tumor microenvironment and allow high-throughput drug screening. Of particular interest, in vitrohuman 3D tissue constructs, produced by the self-assembly method of tissue engineering, have been successfully used to model the tumor microenvironment and now represent a very promising approach to further develop diverse cancer models. In this review, we describe the importance of the tumor microenvironment and present the existing in vitro cancer models generated through the self-assembly method of tissue engineering. Lastly, we highlight the relevance of this approach to mimic various and complex tumors, including basal cell carcinoma, cutaneous neurofibroma, skin melanoma, bladder cancer, and uveal melanoma.

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Stroma in normal and cancer wound healing

Cited by 33 publications

References 90 publications

CD147 Expression Is Associated with Tumor Proliferation in Bladder Cancer via GSDMD

CD147 Expression Is Associated with Tumor Proliferation in Bladder Cancer via GSDMD

Oral cancer‐associated fibroblasts predict poor survival: Systematic review and meta‐analysis

Human Organ-Specific 3D Cancer Models Produced by the Stromal Self-Assembly Method of Tissue Engineering for the Study of Solid Tumors

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