Stromal and epithelial cells react differentially to c-kit in fibroepithelial tumors of the breast

Logullo, Ângela Flávia; Nonogaki, Suely; Maciel, Maria do Socorro; Mourão-Neto, Mário; Soares, Fernando Augusto

doi:10.3892/mmr_00000041

Cited by 2 publications

(2 citation statements)

References 21 publications

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“…The lack of existing research with similar design hinders the correlation of results. The higher epithelial immunoreactivity of CD117 in fibroadenomas in relation to benign PTB was similar to the results of Logullo et al 31 Djordjevic and Hanna 19 reported that 75% of the CF cases studied and 86% of the benign PTB presented epithelial positivity for CD117, considering a 5% cutoff point in the epithelial cells. A cutoff point was not used here, but rather the association between the immunoreactivity score and tumor types.…”

Section: Discussionsupporting

confidence: 89%

Utility of Ki-67, CD10, CD34, p53, CD117, and Mast Cell Content in the Differential Diagnosis of Cellular Fibroadenomas and in the Classification of Phyllodes Tumors of the Breast

et al. 2014

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Adequate management of phyllodes tumors of the breast (PTB) remains a challenge because of the difficulty in correctly establishing preoperative diagnosis. The aim of this study was to evaluate the usefulness of Ki-67, CD10, CD34, p53, CD117, and of the number of mast cells in the differential diagnosis of benign PTB and cellular fibroadenomas (CFs) as well as in the grading of PTB. Fifty-one primary PTB and 14 CFs were examined by immunohistochemistry.When evaluating CD117 expression, higher epithelial expression was present in CF as well as an increased number of mast cells in benign PTB. Stromal expression of Ki-67, CD10, CD34, and p53 were relevant to PTB grading, of which the first 3 showed significance in the distinction of benign and borderline PTB, as well as between benign and malignant PTB. P53 was relevant only for the discrimination between benign and malign PTB. None of the markers showed significance in distinguishing between borderline and malign PTB.

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Section: Discussionsupporting

confidence: 89%

Utility of Ki-67, CD10, CD34, p53, CD117, and Mast Cell Content in the Differential Diagnosis of Cellular Fibroadenomas and in the Classification of Phyllodes Tumors of the Breast

et al. 2014

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“…and Kuijper et al . Additional work on biomarker expression in epithelial and stromal elements of phyllodes tumours lends further credence to their interactions . For example, the level of CXCR4, an epithelial–stromal interaction‐related molecule, was found to be increased in the stromal component of higher‐grade phyllodes tumours …”

Section: Epithelial–stromal Interactions In Phyllodes Tumoursmentioning

confidence: 83%

Phyllodes tumours of the breast: a consensus review

Ács²,

et al. 2015

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Phyllodes tumours constitute an uncommon but complex group of mammary fibroepithelial lesions. Accurate and reproducible grading of these tumours has long been challenging, owing to the need to assess multiple stratified histological parameters, which may be weighted differently by individual pathologists. Distinction of benign phyllodes tumours from cellular fibroadenomas is fraught with difficulty, due to overlapping microscopic features. Similarly, separation of the malignant phyllodes tumour from spindle cell metaplastic carcinoma and primary breast sarcoma can be problematic. Phyllodes tumours are treated by surgical excision. However, there is no consensus on the definition of an appropriate surgical margin to ensure completeness of excision and reduction of recurrence risk. Interpretive subjectivity, overlapping histological diagnostic criteria, suboptimal correlation between histological classification and clinical behaviour and the lack of robust molecular predictors of outcome make further investigation of the pathogenesis of these fascinating tumours a matter of active research. This review consolidates the current understanding of their pathobiology and clinical behaviour, and includes proposals for a rational approach to the classification and management of phyllodes tumours.

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Stromal and epithelial cells react differentially to c-kit in fibroepithelial tumors of the breast

Cited by 2 publications

References 21 publications

Utility of Ki-67, CD10, CD34, p53, CD117, and Mast Cell Content in the Differential Diagnosis of Cellular Fibroadenomas and in the Classification of Phyllodes Tumors of the Breast

Utility of Ki-67, CD10, CD34, p53, CD117, and Mast Cell Content in the Differential Diagnosis of Cellular Fibroadenomas and in the Classification of Phyllodes Tumors of the Breast

Phyllodes tumours of the breast: a consensus review

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