Stromal cell-derived factor-1 but not its receptor, CXCR4, gene variants increase susceptibility and pathological development of hepatocellular carcinoma

Abstract

SDF-1-3'A gene polymorphism could be considered as a factor related to an increased susceptibility to the risk and pathological development of HCC.

Association of genetic polymorphisms of CXCL12/SDF1 gene and its receptor, CXCR4, to the susceptibility and prognosis of non-small cell lung cancer

“…Also CXCL12/SDF1 and CXCR4 may also play a tissue-specific role, and different regulatory mechanisms may apply to different tumors [31][32][33][34][35]. Nevertheless, our data did demonstrate that the polymorphisms of CXCL12/SDF1 and CXCR4 gene had significant associations with susceptibility to and prognosis of NSCLC in our population.…”

CXCL12 G801A polymorphism and cancer risk: An updated meta-analysis

“…Upon reviewing the abstracts, 10 articles were excluded since they were not case-control studies. After further examination of articles on full-text basis, 10 papers were excluded for P<0.05 in control HWE test [18][19][20][21] or failing to provide sufficient genotype data [22][23][24][25][26][27] . As a result, a total of 29 papers were included.…”

Effects of E‐cadherin (CDH1) gene promoter polymorphisms on the risk and clinicopathological development of hepatocellular carcinoma

“…Epidemiological studies indicate that both environmental and genetic factors mediate an individual's susceptibility to cancer; i.e., inherited mutations or alterations in certain genes could make individuals more or less susceptible to developing certain cancers. Several single-nucleotide polymorphisms (SNPs), such as stromal cell-derived factor-1 and tumor necrosis factor-alpha (TNF-a) G-308A, are predictive factors related to a higher risk of HCC [6,7]. The identification of genetic factors related to HCC susceptibility may help elucidate the complex process of hepatocarcinogenesis and improve the scientific basis for preventative intervention.…”