Stromal Cell-Derived Factor-1a Autocrine/Paracrine Signaling Contributes to Spatiotemporal Gradients in the Brain

Hickey, K.; Grassi, Shannon M.; Caplan, Michael R.; Stabenfeldt, Sarah E.

doi:10.1007/s12195-020-00643-y

Cited by 5 publications

(5 citation statements)

References 36 publications

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“…We also observed potential Cxcl12a-Cxcr4b, and Fgf10a-Fgfr2-based autocrine interactions in glial pituicytes 89 . CXCL12-CXCR4 functions as a chemokine and neurotransmitter in the developing brain and as mitogen in brain tumors 90–93 .…”

Section: Discussionsupporting

confidence: 56%

A ligand-receptor interactome atlas of the zebrafish

Chodkowski

Zieleziński

Anbalagan

2022

Preprint

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Studies in zebrafish can unravel the functions of cellular communication and thus identify novel bench-to-bedside drugs targeting cellular communication signalling molecules. Due to the incomplete annotation of zebrafish proteome, the knowledge of zebrafish receptome, secretome and tools to explore their interactome is limited. To address this gap, we de novo predicted the cellular localization of zebrafish reference proteome using deep learning algorithm. We combined the predicted and existing annotations on cellular localization of zebrafish proteins, and created repositories of zebrafish secretome, receptome, and interactome as well as associated diseases and targeting drugs. Unlike other tools, our interactome atlas is primarily based on physical interaction data of zebrafish proteome. The resources are available as R and Python scripts (https://github.com/DanioTalk). DanioTalk provides a novel resource for researchers interested in targeting cellular communication in zebrafish, as we demonstrate in applications studying synapse and axo-glial interactome.

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Section: Discussionsupporting

confidence: 56%

A ligand-receptor interactome atlas of the zebrafish

Chodkowski

Zieleziński

Anbalagan

2022

Preprint

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“…In our study, patients with cardioembolic stroke subtype had significantly higher levels of SDF-1a, also known as CXCL12, a member of the CXC chemokine family. SDF-1a is a chemoattractant cytokine with diverse biological functions including stem cell migration, proliferation, cell apoptosis and angiogenesis [20] and is constitutively expressed by many tissues, including the heart [21] and the brain [22]. It is known that SDF-1a has various functions in the brain during development and in adulthood [23].…”

Section: Discussionmentioning

confidence: 99%

Inflammation biomarkers in acute ischemic stroke according to different etiologies

Meisinger

Freuer

Schmitz

et al. 2023

Euro J of Neurology

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BackgroundHigh throughput technologies provide new opportunities to further investigate the pathophysiology of ischemic strokes. The present cross‐sectional study aimed to evaluate potential associations between the etiologic subtypes of ischemic stroke and blood‐based proteins.MethodsWe investigated the associations between ischemic stroke subtypes and a panel of circulating inflammation biomarkers in 364 patients included in the Stroke Cohort Augsburg (SCHANA). Stroke etiologies were categorized according to the TOAST (Trial of Org 10172 in Acute Stroke Treatment) classification. Serum concentrations of 52 biomarkers were measured using the Bio‐Plex Pro™ Human Cytokine Screening Panel, ICAM‐1 set and VCAM‐1 set, plus the Pro™ Human TH17 cytokine sCD40L set and IL31 set (all Bio‐Rad, USA). Multivariable linear regression models were used to examine associations. Point estimates were calculated as the mean difference in ‐standardized cytokine levels on the log2‐scale.ResultsStromal‐cell‐derived‐factor 1 alpha (SDF‐1a) showed significantly higher serum levels in cardioembolic compared with large vessel atherosclerotic stroke (β = 0.48; 95% CI 0.22; 0.75; Padj = 0.036). Significantly lower levels of interleukin‐6 (IL‐6) (β = −0.53; 95% CI −0.84; −0.23; Padj = 0.036) and macrophage migration inhibitory factor (MIF) (β = −0.52; 95% CI −0.84; −0.21; Padj = 0.043) were found in the small vessel versus large vessel stroke subtype.ConclusionsImmune dysregulations observed in different stroke subtypes might help uncover pathophysiological mechanisms of the disease. Further studies are needed to validate identified biomarkers in diverse study populations before they can potentially be used in clinical practice to further improve stroke management and patient outcomes.

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“…While SDF-1α has been actively pursued as a potential target for drug development because it can regulate multiple cellular processes such as cell migration and survival, angiogenesis, and immune responses, the extremely short half-life (26-min in vivo) renders its therapeutic effects as a chemokine insigni cant 29 . In particular, the therapeutic e cacy of SDF-1α chemokine could be less effective within the ischemic microenvironment in vivo due to many cytokine-binding proteases, inhibitors and soluble cytokine receptors that can interfere with the effect of SDF-1α 30 .…”

Section: Discussionmentioning

confidence: 99%

Vascular regeneration and skeletal muscle repair induced by long-term exposure to SDF-1α derived from engineered mesenchymal stem cells after hindlimb ischemia

Park

Kim

Park

et al. 2023

Preprint

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Despite the recent progress in medical and endovascular therapy, the prognosis for patients with critical limb ischemia (CLI) remains poor. In response, various stem cells and growth factors have been assessed for use in therapeutic neovascularization and limb salvage in CLI patients. However, the clinical outcomes of cell-based therapeutic angiogenesis have not provided the promised benefits, reinforcing the need for novel cell-based therapeutic angiogenesis strategies to cure untreatable CLI patients. In the present study, we investigated genetically engineered mesenchymal stem cells (MSCs) derived from human bone marrow that continuously secrete stromal-derived factor-1α (SDF1α-eMSCs), and demonstrated that intramuscular injection of SDF1α-eMSCs can provide long-term paracrine effects in limb ischemia and effectively contribute vascular regeneration as well as skeletal muscle repair through increased phosphorylation of the ERK and Akt within the SDF1α/CXCR4 axis. These results provide compelling evidence that genetically engineered MSCs with SDF-1α can be an effective strategy for successful limb salvage in limb ischemia.

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Stromal Cell-Derived Factor-1a Autocrine/Paracrine Signaling Contributes to Spatiotemporal Gradients in the Brain

Cited by 5 publications

References 36 publications

A ligand-receptor interactome atlas of the zebrafish

A ligand-receptor interactome atlas of the zebrafish

Inflammation biomarkers in acute ischemic stroke according to different etiologies

Vascular regeneration and skeletal muscle repair induced by long-term exposure to SDF-1α derived from engineered mesenchymal stem cells after hindlimb ischemia

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