Stromal cells promote bone invasion by suppressing bone formation in ameloblastoma

Sathi, Gul San Ara; Nagatsuka, Hitoshi; Tamamura, Ryo; Fujii, Michihiko; Gündüz, Mehmet; Inoue, Miho; Rivera, Rosario Santos; Nagai, Noriyuki

doi:10.1111/j.1365-2559.2008.03127.x

Cited by 22 publications

(14 citation statements)

References 32 publications

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“…Our current data that TGF‐β and BMP4 expression in myxoid‐type stroma was associated with high levels of RANKL and CD68‐positive osteoclasts and precursor cells concurred with the findings from an earlier study by our group . TGF‐β and BMP4, which are abundantly present in bone matrix, are released and activated under pathological conditions .…”

Section: Discussionsupporting

confidence: 92%

Parenchyma–stromal interactions induce fibrosis by secreting CCN2 and promote osteoclastogenesis by stimulating RANKL and CD68 through activated TGF‐β/BMP4 in ameloblastoma

Takebe

Tsujigiwa

Katase

et al. 2016

J Oral Pathology Medicine

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Section: Discussionsupporting

confidence: 92%

Parenchyma–stromal interactions induce fibrosis by secreting CCN2 and promote osteoclastogenesis by stimulating RANKL and CD68 through activated TGF‐β/BMP4 in ameloblastoma

Takebe

Tsujigiwa

Katase

et al. 2016

J Oral Pathology Medicine

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“…Different types were found mixed together in over half of the cases, as has previously been reported (4,29,30) . All of the progressive front were consisted of columnar cells.…”

Section: Discussionsupporting

confidence: 61%

<b>Histopathological and Immunohistochemical Characteristics of the Progressive Front of Ameloblastoma </b>

Yasuoka

Kato

2015

Int J Oral-Med Sci

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Ameloblastoma is a slow-developing benign odontogenic tumor, but it has relatively large number of local recurrence. Ameloblastoma was classified on the basis of the morphology that predominates in the tumor itself into plexiform type, follicular type, and other subtypes, and there have been comparative histological and clinical studies that include prognosis predictions for the different types. However, there are no conclusions regarding histological patterns and tumor activities have been reached.The purpose of the present study was to perform a detailed investigation of the progressive front of solid/multicystic type ameloblastoma in order to search for possible prognostic factors.For this study, 22 cases were chosen, in whom solid/multicystic type of a ameloblastoma.Progressive fronts of the solid/multicystic type ameloblastoma were morphologically classified into six types; plexiform, follicular, basaloid cell, sheet, trabecular and polycystic types, and immunohistochemical and morphometrical comparative studies were performed.Proliferative activity of columnar cells was highest in basaloid cell type at 1.9%. Periostin showed moderate to strong positive reaction in columnar cells of plexiform and basaloid cell types. Columnar and stellate-reticulum-like cells of basaloid cell type showed strong positive reaction for VEGF. The highest microvessel density and microvessel area using CD105 in basaloid cell type were 48.2±24.2 and 11.4±8.6%, respectively.The result of this study suggested with resection of solid/multicystic type ameloblastoma, it is important the prognosis observation to base judgment on the morphology of cells in the progressive front or in the vicinity of the resected surface.

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“…Novel strategies for successful tumor treatment should focus on the elimination of CSCs. In this study, we analyzed immunohistochemical staining to detect the expression of three different CSC markers in relation to the proliferation activity of the tumor cells in ameloblastoma, a highly apoptosis-resistant and invasive tumor with a high recurrence rate and possesing different histological patterns (18)(19)(20)(21). Increasing evidence highlights the role of CD133 as a marker of CSCs in various human tumors as well as in ameloblastoma (22,23).…”

Section: Discussionmentioning

confidence: 99%

Analysis of immunoexpression of common cancer stem cell markers in ameloblastoma

Sathi

Tamamura

Tsujigiwa

et al. 2011

Experimental and Therapeutic Medicine

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Abstract. Recent studies have established that, in benign tumors, a large number of cancer stem cells are present, which have great implications in tumor development. However, in ameloblastoma, a highly aggressive, locally invasive tumor with a high recurrence rate, whether or not cancer stem-like cells are present remains undetermined. Therefore, in this study we analyzed the protein expression of three candidate stem cell markers in ameloblastoma. Immunohistochemical staining for cancer stem cell (CSC) markers (CD133, CD44 and ABCG2) and for the proliferation marker Ki-67 was performed using 23 ameloblastoma cases. In all 23 samples, CD133, CD44 and ABCG2 were expressed. Nine (39.13%) cases showed high expression and 14 cases (60.87%) showed low expression for CD133. Twelve of the 23 cases (52.17%) showed high expression and 11 cases (47.83%) showed low expression for both CD44 and ABCG2, respectively. Ki-67 was mainly expressed in peripheral ameloblast-like cells, suggesting that these cells have a higher degree of differentiation and, therefore, are less likely to contain cancer stem-like cells. On the other hand, cells positive for CSC markers situated at the close proximity to peripheral cells were devoid of Ki-67 and may have the potential to be cancer stem-like cells. After analyzing the correlation between expression of three CSC markers with clinicopathological factors and Ki-67 expression, only CD44 expression was correlated with tumor recurrence (P=0.0391). In conclusion, this study showed various expression patterns of different types of cancer stem cell markers and the presence of candidate CSC-like cells in ameloblastoma, which are possibly involved in cell proliferation, tumor progression and recurrence.

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Stromal cells promote bone invasion by suppressing bone formation in ameloblastoma

Cited by 22 publications

References 32 publications

Parenchyma–stromal interactions induce fibrosis by secreting CCN2 and promote osteoclastogenesis by stimulating RANKL and CD68 through activated TGF‐β/BMP4 in ameloblastoma

Parenchyma–stromal interactions induce fibrosis by secreting CCN2 and promote osteoclastogenesis by stimulating RANKL and CD68 through activated TGF‐β/BMP4 in ameloblastoma

<b>Histopathological and Immunohistochemical Characteristics of the Progressive Front of Ameloblastoma </b>

Analysis of immunoexpression of common cancer stem cell markers in ameloblastoma

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