Stromal STAT5-Mediated Trophic Activity Regulates Hematopoietic Multipotent Progenitor Niche Factors

Wang, Zhengqi; Emmel, Grace; Lim, Hong Seo; Kosters, Astrid; Ghosn, Eliver; Qiu, Peng; Bunting, Kevin D.

doi:10.1182/blood-2022-158988

Cited by 1 publication

(1 citation statement)

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“…The loss of EBF3 induces osteogenic differentiation, leading to a reduced LepR + MSC number and HSC niche factors following the occlusion of marrow cavities [88]. Other factors like Erk5 [89] and STAT5a/b [90] are also important for maintaining a normal hematopoietic niche. Bmi1, a main component of polycomb repressive complex 1 (PRC1), is critical for repressing different adipogenic genes.…”

Section: Mechanisms Controlling Fate Decisions Of Lepr + Cellsmentioning

confidence: 99%

From Marrow to Bone and Fat: Exploring the Multifaceted Roles of Leptin Receptor Positive Bone Marrow Mesenchymal Stromal Cells

Prasad,

Cancelas

2024

Cells

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The bone marrow (BM) stromal cell microenvironment contains non-hematopoietic stromal cells called mesenchymal stromal cells (MSCs). MSCs are plastic adherent, form CFU-Fs, and give rise to osteogenic, adipogenic, chondrogenic progenitors, and most importantly provide HSC niche factor chemokine C-X-C motif ligand 12 (CXCL12) and stem cell factor (SCF). Different authors have defined different markers for mouse MSC identification like PDGFR+Sca-1+ subsets, Nestin+, or LepR+ cells. Of these, the LepR+ cells are the major source of SCF and CXCL12 in the BM microenvironment and play a major role in HSC maintenance and hematopoiesis. LepR+ cells give rise to most of the bones and BM adipocytes, further regulating the microenvironment. In adult BM, LepR+ cells are quiescent but after fracture or irradiation, they proliferate and differentiate into mesenchymal lineage osteogenic, adipogenic and/or chondrogenic cells. They also play a crucial role in the steady-state hematopoiesis process, as well as hematopoietic regeneration and the homing of hematopoietic stem cells (HSCs) after myeloablative injury and/or HSC transplantation. They line the sinusoidal cavities, maintain the trabeculae formation, and provide the space for HSC homing and retention. However, the LepR+ cell subset is heterogeneous; some subsets have higher adipogenic potential, while others express osteollineage-biased genes. Different transcription factors like Early B cell factor 3 (EBF3) or RunX2 help maintain this balance between the self-renewing and committed states, whether osteogenic or adipogenic. The study of LepR+ MSCs holds immense promise for advancing our understanding of HSC biology, tissue regeneration, metabolic disorders, and immune responses. In this review, we will discuss the origin of the BM resident LepR+ cells, different subtypes, and the role of LepR+ cells in maintaining hematopoiesis, osteogenesis, and BM adipogenesis following their multifaceted impact.

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Section: Mechanisms Controlling Fate Decisions Of Lepr + Cellsmentioning

confidence: 99%