Stromelysin-3 (ST-3): immunohistochemical characterization of the matrix metalloproteinase (MMP)-11 in benign and malignant skin tumours and other skin disorders

Thewes, M; Worret, W.-I.; Engst, R; Ring, Johannes

doi:10.1046/j.1365-2230.1999.00431.x

Cited by 43 publications

(34 citation statements)

References 20 publications

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“…Interestingly, as observed for MMP-9, MMP-11 is not exclusively released by malignant cells, but also by the surrounding mesenchymal cells (Thewes et al, 1999).…”

Section: Neoplastic Diseasesmentioning

confidence: 58%

“…Matrix metalloproteinase-11 is widely expressed in both normal and pathological remodeling processes, such as embryonic implantation (Lefebvre et al, 1995), placentation, interdigitation, osteogenesis, spinal cord morphogenesis, epithelium growth, larval tissue resorption (Berry et al, 1998), morphogenesis, menstrual breakdown, post-partum involution, ovulation (Hägglund et al, 1999), post-weaning involution, inflammation, wound healing (Wolf et al, 1992), benign tumor proliferation, and tissue invasion (Rio, 2005;Rouyer et al, 1994;Thewes et al, 1999). In both normal and pathological conditions, MMP-11 is mostly secreted by fibroblasts.…”

Section: Structural Peculiarities and Biological Aspectsmentioning

confidence: 99%

See 1 more Smart Citation

Human matrix metalloproteinases: An ubiquitarian class of enzymes involved in several pathological processes

Sbardella

Fasciglione

Gioia

et al. 2012

Molecular Aspects of Medicine

209

212

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a b s t r a c tHuman matrix metalloproteinases (MMPs) belong to the M10 family of the MA clan of endopeptidases. They are ubiquitarian enzymes, structurally characterized by an active site where a Zn 2+ atom, coordinated by three histidines, plays the catalytic role, assisted by a glutamic acid as a general base. Various MMPs display different domain composition, which is very important for macromolecular substrates recognition. Substrate specificity is very different among MMPs, being often associated to their cellular compartmentalization and/or cellular type where they are expressed. An extensive review of the different MMPs structural and functional features is integrated with their pathological role in several types of diseases, spanning from cancer to cardiovascular diseases and to neurodegeneration. It emerges a very complex and crucial role played by these enzymes in many physiological and pathological processes.

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“…Interestingly, as observed for MMP-9, MMP-11 is not exclusively released by malignant cells, but also by the surrounding mesenchymal cells (Thewes et al, 1999).…”

Section: Neoplastic Diseasesmentioning

confidence: 58%

Section: Structural Peculiarities and Biological Aspectsmentioning

confidence: 99%

Human matrix metalloproteinases: An ubiquitarian class of enzymes involved in several pathological processes

Sbardella

Fasciglione

Gioia

et al. 2012

Molecular Aspects of Medicine

209

212

View full text Add to dashboard Cite

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“…Normal MMP-11 expression is present during embryogenesis and wound healing, and its expression in stressed epithelial cells is detected in the vicinity of fibroblasts (Boulay et al, 2001). The MMP-11 expression is observed in the area that surrounds malignant epithelial tumour cells and sometimes in tumour cells of oesophageal, oral, papillary thyroid, colorectal, skin and ovarian carcinomas (Thewes et al, 1999;Mueller et al, 2000;Soni et al, 2003;Wasenius et al, 2003;Yamashita et al, 2004). Hence, MMP-11 gene expression seems to be associated with tumour progression (Basset et al, 1997).…”

Section: Discussionmentioning

confidence: 99%

Study of matrix metalloproteinases and their inhibitors in prostate cancer

Escaff

Fernández²,

González

et al. 2010

Br J Cancer

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BACKGROUND: Extracellular matrix metalloproteases (MMPs) have raised an extraordinary interest in cancer research because of their potential role in basal membrane and extracellular matrix degradation, consequently facilitating tumour invasion and metastases development. METHODS: An immunohistochemical study was performed using tissue arrays and specific antibodies against MMPs 1, 2, 7, 9, 11, 13, 14, and their tissue inhibitors, TIMPs 1, 2 and 3. More than 2600 determinations on cancer specimens from 133 patients with clinically localised prostate carcinoma, 20 patients with prostatic intraepithelial neoplasia and 50 patients with benign prostate hyperplasia and controls, were performed. RESULTS: When compared with benign pathologies, prostate carcinomas had higher expression of all MMPs and TIMPs. Dendogram shows a first-order division of tumours into two distinct MMPs/TIMPs molecular profiles, one of them with high MMPs/TIMs expression profile (n ¼ 70; 52.6%). Tumours with high expression of MMP-11 or -13, or cluster thereof, were significantly associated with higher probability of biochemical recurrence. The prevalence of prostate cancer is so high that it could be considered as a normal age-related phenomenon (Hughes et al, 2005). Several published autopsy series have shown that up to one-third of men between the ages of 30 and 40 years harbour histological evidence of prostate carcinoma (Sakr et al, 1994).A significant minority of patients undergoing radical prostatectomy for clinical organ-confined disease will ultimately be found to have pathological evidence of spread outside the prostate. Although these patients may be expected to have progression and survival rates comparable to those of patients with clinical advanced clinical disease, as defined by grade and serum prostatespecific antigen (PSA) level, those men who present with clinical stage T3 are likely to have greater tumour volume, higher grade and increased likelihood of regional spread. Currently, the majority of men undergoing prostatectomy for pathologically advanced disease are categorised as high risk on the basis of serum PSA value or biopsy Gleason score. Nevertheless, there is some overlap in the groups of men undergoing radical prostatectomy for clinical stage T3 and for pathological stage T3 (Meng and Carrol, 2007).Despite recent improvement in diagnostic and therapeutic techniques, the survival rate of prostate cancer patients remains poor due to post-treatment recurrence disease. Despite all the recent efforts in the identification of molecular mechanisms involved in the progression of prostate cancer, tumour progression in the prostatic compartment, as well as in the metastasis compartment, is poorly understood (Logothetis and Lin, 2005). These pitfalls underscore the need for new risk markers that allow the early detection of carcinogenesis and, therefore, of cancer relapse.Degradation of the stromal connective tissue and basement membrane components are key elements in tumour invasion and metastasis. This is particularly true wi...

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“…Therefore, the counter regulation of MMPs and cytokines seems to be important for both activities. Several MMPs were previously reported to be elevated in psoriatic lesions (Table 1) [23][24][25][26] . The IFN-α produced by plasmacytoid predendritic cells was recently demonstrated to be an important initiator in the development of psoriasis 27,28 .…”

Section: Discussionmentioning

confidence: 99%

“…However, there was no significant difference in the expression of TIMP-1, which is a specific inhibitor of MMP-9, between the non-lesions of the two types of psoriasis. Although several MMPs are known to be elevated in psoriasis, these elevations have also been reported to be associated with other skin disorders 25,39,40 . In lichen planus, the digestion of the basement membrane by MMP-2 may contribute to the pathogenesis by inducing an altered integrin expression in basal keratinocytes and ultimately blister formation 39 .…”

Section: Discussionmentioning

confidence: 99%

The Increased Expression of Matrix Metalloproteinase-9 Messenger RNA in the Non-lesional Skin of Patients with Large Plaque Psoriasis Vulgaris

Lee

Lew

2009

Ann Dermatol

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Background:A difference of the interleukin-18 (IL-18) mRNA expression among several proinflammatory genes was previously observed between large plaque (LP) psoriasis patients (more than 5 cm lesions are typical) and small plaque (SP) psoriasis patients (1∼2 cm lesions are typical). Therefore, it is necessary to test whether there is any difference in the expression of the genes that activate IL-18 or the expression of genes that are induced by IL-18. Objective: To test the differential mRNA expressions of caspase-1, STAT-6, MMP-1, MMP-2, MMP-9 and TIMP-1 according to the clinical types of psoriasis vulgaris lesions in Korean patients, we have analyzed the skin samples of psoriasis vulgaris patients. Methods: The total cellular RNA of skin samples from groups of patient with LP and SP psoriasis was analyzed by performing real-time PCR (the Taqman method) to compare the differences in the mRNA expressions. Results: The caspase-1 and STAT-6 mRNA expression levels from the SP lesional skin of the patients were increased compared with the caspase-1 and STAT-6 mRNA expression levels from SP non-lesional skin or normal skin, but these expression levels from the SP non-lesional skin were not significantly different from those of the LP non-lesional skin. Among MMP-1, MMP-2, MMP-9 and TIMP-1, the expressions of MMP-1, MMP-2 and MMP-9 mRNA were increased in the SP lesional skin compared with those of the SP non-lesional skin. The MMP-1 mRNA expressions in both the LP and SP lesional skin were increased compared with those in the normal skin (p=0.028 and p=0.007 respectively). The MMP-9 mRNA expression in the LP non-lesional skin was elevated compared with the MMP-9 mRNA expression in the SP non-lesional skin (p=0.047). The TIMP-1 mRNA expression levels from the non-lesional skin and the lesional skin of the psoriasis patients and the normal skin samples were not significantly different. Conclusion: The increased expression of MMP-9 mRNA in the LP non-lesional skin compared to that of the SP non-lesional skin in the psoriatic skin suggests that the increased MMP-9 mRNA expression is related to the large size type of lesion.

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Stromelysin-3 (ST-3): immunohistochemical characterization of the matrix metalloproteinase (MMP)-11 in benign and malignant skin tumours and other skin disorders

Cited by 43 publications

References 20 publications

Human matrix metalloproteinases: An ubiquitarian class of enzymes involved in several pathological processes

Human matrix metalloproteinases: An ubiquitarian class of enzymes involved in several pathological processes

Study of matrix metalloproteinases and their inhibitors in prostate cancer

The Increased Expression of Matrix Metalloproteinase-9 Messenger RNA in the Non-lesional Skin of Patients with Large Plaque Psoriasis Vulgaris

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