Strong and bioactive bioinspired biomaterials, next generation of bone adhesives

Shokri, Mahshid; Kharaziha, Mahshid; Dalili, Faezeh; Eslaminejad, Mohamadreza Baghaban; Tafti, Hossein Ahmadi

doi:10.1016/j.cis.2022.102706

Cited by 31 publications

(27 citation statements)

References 212 publications

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“…There are numerous natural polymers that function as bone bio-based adhesives, mostly polymers consisted of animal-inspired bio-based adhesives, such as frog, sandcastle, mussel, polysaccharides, and fibrin glue [31][32][33][34][35][36][37][38]. The most broadly utilized material for soft tissue bio-based adhesives, sealants, and hemostatic agents is fibrin.…”

Section: Sources and Types Of Bio-based Adhesivesmentioning

confidence: 99%

Bio-Based Adhesives for Orthopedic Applications: Sources, Preparation, Characterization, Challenges, and Future Perspectives

Nuswantoro

Juliadmi

Mardawati

et al. 2022

Designs

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Bone fracture healing involves complex physiological processes that require biological events that are well coordinated. In recent decades, the process of fracture healing has been upheld through various treatments, including bone implants and bio-adhesive utilization. Bio-adhesion can be interpreted as the process in which synthetic or natural materials adhere to body surfaces. Bio-based adhesives have superiority in many value-added applications because of their biocompatibility, biodegradability, and large molecular weight. The increased variety and utilization of bio-based materials with strong adhesion characteristics provide new possibilities in the field of orthopedics in terms of using bio-based adhesives with excellent resorbability, biocompatibility, ease of use, and low immunoreactivity. The aim of this review is to provide comprehensive information and evaluation of the various types of bio-based adhesives used clinically with a specific focus on their application in orthopedics. The main properties of bio-based adhesives, their benefits, and challenges compared with the traditional bio-based materials in orthopedics, as well as the future perspectives in the field, have also been outlined and discussed.

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Section: Sources and Types Of Bio-based Adhesivesmentioning

confidence: 99%

Bio-Based Adhesives for Orthopedic Applications: Sources, Preparation, Characterization, Challenges, and Future Perspectives

Nuswantoro

Juliadmi

Mardawati

et al. 2022

Designs

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“…They also should be biocompatible, and their byproducts should be nontoxic and biocompatible. , In addition, they should be mechanically robust with lower stiffness than metallic fixation devices to avoid stress shielding . There are various types of natural and synthetic bioadhesives for different applications. , Weak sealing ability, loss of bond to bone, wound infection, and tissue necrosis are issues facing most synthetic adhesives. In other words, natural bone adhesives based on polysaccharides and fibrin glue show drawbacks including the weak adhesion strength to bone compared to synthetic adhesives, especially in a wet environment, low cohesive strength, and the risk of viral transmission in biological adhesives, limiting their applications …”

Section: Introductionmentioning

confidence: 99%

Multifunctional Bioinspired Bredigite-Modified Adhesive for Bone Fracture Healing

Moazami

Kharaziha

Emadi

et al. 2023

ACS Appl. Mater. Interfaces

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Despite recent advances in bone adhesives applied for full median sternotomy, the regeneration of bone defects has remained challenging since the healing process is hampered by poor adhesiveness, limited bioactivity, and lack of antibacterial functions. Bioinspired adhesives by marine organisms provide a novel concept to circumvent these problems. Herein, a dual crosslink strategy is employed in designing a multifaceted bioinspired adhesive consisting of a catechol amine-functionalized hyperbranched polymer (polydopamine-co-acrylate, PDA), bredigite (BR) nanoparticles, and Fe 3+ ions. The hybrid adhesives exhibit strong adhesion to various substrates such as poly(methyl methacrylate), glass, bone, and skin tissues through synergy between irreversible covalent and reversible noncovalent cross-linking, depending on the BR content. Noticeably, the adhesion strength of hybrid adhesives containing 2 wt % BR nanoparticles to bone tissues is 2.3 ± 0.8 MPa, which is about 3 times higher than that of pure PDA adhesives. We also demonstrate that these hybrid adhesives not only are bioactive and accelerate in vitro bone-like apatite formation but also exhibit antibacterial properties against Staphylococcus aureus, depending on the BR concentration. Furthermore, the superior cellular responses in contact with hybrid adhesives, including improved human osteosarcoma MG63 cell spreading and osteogenic differentiation, are achieved owing to the appropriate ion release and flexibility of the cross-linked double-network adhesive. In summary, multifunctional hybrid PDA/BR adhesives with appreciable osteoconductive, mechanical, and antibacterial properties represent the potential applications for median sternotomy surgery as a bone tissue adhesive.

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“…Over the last two decades, outstanding success has been achieved in mussel-inspired biomaterials, mainly from the design and synthesis of diverse mussel-inspired compounds to the exploitation of potential applications in the field of MSDs. However, hitherto, there have been only two review articles on mussel-inspired biomaterials with a sparse focus on the applications in MSDs, 24 , 25 to which the tremendous vigor in this emerging field displays striking contrast. Therefore, it is important to shed light on the recent progress and future trend in this field.…”

Section: Introductionmentioning

confidence: 99%

Mussel-Based Biomimetic Strategies in Musculoskeletal Disorder Treatment: From Synthesis Principles to Diverse Applications

Yan¹,

Lv²,

Wu³

et al. 2023

IJN

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Musculoskeletal disorders are the second leading cause of disability worldwide, posing a huge global burden to the public sanitation system. Currently, tissue engineering-based approaches act as effective strategies, which are, however, challenging in limited application scenarios. Mussel-based biomimetic materials, exhibit numerous unique properties such as intense adhesion, biocompatibility, moisture resistance, and injectability, to name only a few, and have attracted extensive research interest. In particular, featuring state-of-the-art properties, mussel-inspired biomaterials have been widely explored in innumerable musculoskeletal disorder treatments including osteochondral defects, osteosarcoma, osteoarthritis, ligament rupture, and osteoporosis. Nevertheless, a comprehensive and timely discussion of their applications in musculoskeletal disorders is insufficient. In this review, we emphasize on (1) the main categories and characteristics of mussel foot proteins and their fundamental mechanisms for the spectacular adhesion in mussels; (2) the diverse synthetic methods and modification of various polymers; and (3) the emerging applications of mussel-biomimetic materials, the future perspectives, and challenges, especially in the area of musculoskeletal disorder. We envision that this review will provide a unique and insightful perspective to improve the development of a new generation of mussel biomimetic strategies.

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Strong and bioactive bioinspired biomaterials, next generation of bone adhesives

Cited by 31 publications

References 212 publications

Bio-Based Adhesives for Orthopedic Applications: Sources, Preparation, Characterization, Challenges, and Future Perspectives

Bio-Based Adhesives for Orthopedic Applications: Sources, Preparation, Characterization, Challenges, and Future Perspectives

Multifunctional Bioinspired Bredigite-Modified Adhesive for Bone Fracture Healing

Mussel-Based Biomimetic Strategies in Musculoskeletal Disorder Treatment: From Synthesis Principles to Diverse Applications

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