Strong and Weak Polyelectrolyte Adsorption onto Oppositely Charged Curved Surfaces

Winkler, Roland G.; Cherstvy, Andrey G.

doi:10.1007/12_2012_183

Cited by 37 publications

(87 citation statements)

References 221 publications

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“…We believe, but have not yet shown, that anisotropic pair potentials could increase the stability range and suppress the fluctuations by organization of particles into polymeric linear arrays, e.g., into spirals as shown in Ref. [29] for a polyelectrolyte on a spherical surface. When wound around the unduloid according to the CK spiral construction these polymers might suppress rupture and aneurysm instabilities.…”

Section: Discussionmentioning

confidence: 86%

Useful scars: Physics of the capsids of archaeal viruses

et al. 2016

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We propose a physical model for the capsids of tailed archaeal viruses as viscoelastic membranes under tension. The fluidity is generated by thermal motion of scarlike structures that are an intrinsic feature of the ground state of large particle arrays covering surfaces with nonzero Gauss curvature. The tension is generated by a combination of the osmotic pressure of the enclosed genome and an extension force generated by filamentous structure formation that drives the formation of the tails. In continuum theory, the capsid has the shape of a surface of constant mean curvature: an unduloid. Particle arrays covering unduloids are shown to exhibit pronounced subdiffusive and diffusive single-particle transport at temperatures that are well below the melting temperature of defect-free particle arrays on a surface with zero Gauss curvature.

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Section: Discussionmentioning

confidence: 86%

Useful scars: Physics of the capsids of archaeal viruses

et al. 2016

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“…The effect on the adsorption/desorption of a polyelectrolyte onto an oppositely charged surface of the presence of added salt in the aqueous solution bathing the surface has been investigated theoretically by several authors [1,61,[68][69][70][71][72]. In particular, based on a generalized mean-field approach, Winkler and Cherstvy [1] proposed a model for the adsorption of a flexible polyelectrolyte on a spherical surface.…”

Section: The Salt-induced Polyion Desorptionmentioning

confidence: 99%

Salt-induced reentrant stability of polyion-decorated particles with tunable surface charge density

Sennato

Carlini

Truzzolillo

et al. 2016

Colloids and Surfaces B: Biointerfaces

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The electrostatic complexation between DOTAP/DOPC unilamellar liposomes and an oppositely charged polyelectrolyte (NaPA) has been investigated in a wide range of the liposome surface charge density. We systematically characterized the reentrant condensation and the charge inversion of polyelectrolyte-decorated liposomes by means of dynamic light scattering and electrophoresis. We explored the stability of this model polyelectrolyte/colloid system at different values of the surface charge of the bare liposomes and by changing two independent control parameters of the suspensions: the polyelectrolyte/colloid charge ratio and the ionic strength of the aqueous suspending medium. The progressive addition of neutral DOPC lipid within the liposome membrane gave rise to an interesting phenomenon which has not been observed previously: the stability diagram of the suspensions showed a novel reentrance due to the crossing of the desorption threshold of the polyelectrolyte. Indeed, at fixed charge density of the bare DOTAP/DOPC liposomes and for a wide range of polyion concentrations, we showed that the simple electrolyte addition first (low salt regime) destabilizes the suspensions because of the enhanced screening of the residual repulsion between the complexes, and then (high salt regime) determines the onset of a new stable phase, originated by the absence of polyelectrolyte adsorption on the particle surfaces. We show that the observed phenomenology can be rationalized within the modified Velegol-Thwar model for heterogeneously charged particles and that the polyelectrolyte desorption fits well the predictions of the adsorption theory of Winkler and Cherstvy [1]. Our findings unambiguously support the picture of the reentrant condensation as driven by the correlated adsorption of the polyelectrolyte chains on the particle surface, providing interesting insights into possible mechanisms for tailoring complex colloids via salt-induced effects.

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“…It stems from a complex fiber structure consisting in interwound nucleosome core particles (NCP) with a histone octamer with ∼146-147 bp of DNA wrapped around it, separated by ∼10-60 bp DNA segments and decorated by a number of other chromatin proteins. Locally, the intricate interplay between the opposite charges on DNA and histones totaling to near zero [110] generates moderate ES forces maintaining the chromatin integrity. As we propose below, the pairing efficiency of chromatin fibers is likely to correlate with their geometrical regularity, which is a complex function of a number of parameters.…”

Section: Interactions Between the Chromatin Fibersmentioning

confidence: 99%

Structure-driven homology pairing of chromatin fibers: the role of electrostatics and protein-induced bridging

Cherstvy

Teif

2013

J Biol Phys

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Chromatin domains formed in vivo are characterized by different types of 3D organization of interconnected nucleosomes and architectural proteins. Here, we quantitatively test a hypothesis that the similarities in the structure of chromatin fibers (which we call "structural homology") can affect their mutual electrostatic and protein-mediated bridging interactions. For example, highly repetitive DNA sequences in heterochromatic regions can position nucleosomes so that preferred inter-nucleosomal distances are preserved on the surfaces of neighboring fibers. On the contrary, the segments of chromatin fiber formed on unrelated DNA sequences have different geometrical parameters and lack structural complementarity pivotal for stable association and cohesion. Furthermore, specific functional elements such as insulator regions, transcription start and termination sites, and replication origins are characterized by strong nucleosome ordering that might induce structure-driven iterations of chromatin fibers. We propose that shape-specific protein-bridging interactions facilitate long-range pairing of chromatin fragments, while for closely-juxtaposed fibers electrostatic forces can in addition yield fine-tuned structurespecific recognition and pairing. These pairing effects can account for some features observed for mitotic and inter-phase chromatins.

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Strong and Weak Polyelectrolyte Adsorption onto Oppositely Charged Curved Surfaces

Cited by 37 publications

References 221 publications

Useful scars: Physics of the capsids of archaeal viruses

Useful scars: Physics of the capsids of archaeal viruses

Salt-induced reentrant stability of polyion-decorated particles with tunable surface charge density

Structure-driven homology pairing of chromatin fibers: the role of electrostatics and protein-induced bridging

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