Strong association between IgA nephropathy and HLA-DR4 antigen

Kashiwabara, Hidehiko; Shishido, Hideo; Tomura, Shigeo; Tuchida, Hiroki; Miyajima, T

doi:10.1038/ki.1982.185

Cited by 75 publications

(27 citation statements)

References 16 publications

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“…We demonstrate that the frequencies of DRB1*04 was increased in patients with IgAN, consistent with other previous reports that HLA-DR4 was associated with IgAN in a Japanese population (P Ͻ 0.04), although the reported P value was not significantly small (Hiki et al 1982;Kashiwabara et al 1982). Moreover, the apparent association between HLA-DRA alleles and IgAN has not been clarified in the Japanese or any other ethnic group; we have demonstrated here for the first time a significant association of three SNPs in the HLA-DRA gene with IgAN.…”

Section: Discussionsupporting

confidence: 81%

Single-nucleotide polymorphisms in the class II region of the major histocompatibility complex in Japanese patients with immunoglobulin A nephropathy

et al. 2002

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involved. As a first step in investigating a possible relationship between HLA class II genes and IgAN, we analyzed the extent of linkage disequilibrium (LD) in this region of chromosome 6p21.3 in a Japanese test population and found extended LD blocks within the class II locus. We designed a case-control association study of singlenucleotide polymorphisms (SNPs) in each of those LD blocks, and determined that SNPs located in the HLA-DRA gene were significantly associated with an increased risk of IgAN (P ϭ 0.000001, odds ratio ϭ 1.91 [95% confidence interval 1.46-2.49]); SNPs in other LD blocks were not. Our data imply that some haplotype of the HLA-DRA locus has an important role in the development of IgAN in Japanese patients.

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Section: Discussionsupporting

confidence: 81%

Single-nucleotide polymorphisms in the class II region of the major histocompatibility complex in Japanese patients with immunoglobulin A nephropathy

et al. 2002

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“…In the past 2 decades, the association of HLA-DRB1 alleles and pIgAN has been studied in various ethnic groups [10,11,12,13,14]. In Japanese and French [19] cohorts, there was a strong association between pIgAN and the HLA-DR4 gene; a study of Japanese patients found that some haplotypes of the HLA-DRA locus had an important role in the development of pIgAN [30, 31].…”

Section: Resultsmentioning

confidence: 99%

“…In the past decades, there were many clinical studies which provided further evidence indicating a marked association of HLA gene polymorphism and pIgAN [2,3,4,5]. Earlier studies have shown that HLA-DR * 4 might be associated with pIgAN, especially in Japanese [10,11,12,13] and Chinese patients [14]. There is a significant association between HLA-DQB1 * 0301 and IgAN patients with a poor clinical outcome [15].…”

Section: Introductionmentioning

confidence: 99%

Human Leukocyte Antigen <i>DRB1</i> Alleles Predict Risk and Disease Progression of Immunoglobulin A Nephropathy in Han Chinese

Cao

Nie

et al. 2008

Am J Nephrol

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The role of human leukocyte antigen (HLA) class II polymorphisms in the pathogenesis and progression of primary immunoglobulin A nephropathy (pIgAN) is unclear. This study aimed to explore the relationship of HLA-DRB1 alleles with the susceptibility and disease progression of pIgAN in Han Chinese. A PCR-based genotyping technique was used to detect HLA-DRB1 alleles in 139 patients with pIgAN and 143 healthy subjects. A total of 37 HLA-DRB1 alleles were detected, of which 30 were found in pIgAN patients and 29 in healthy subjects. In pIgAN patients, the frequencies of HLA-DRB1*140501 (belonging to DR*14) were significantly increased, while the frequencies of HLA-DRB1*070101 (belonging to DR*7) were significantly reduced compared with the healthy individuals. Further stratification analysis revealed that the frequencies of HLA-DRB1*030101 in pIgAN patients with normal renal function were significantly higher than those in patients with renal dysfunction. These findings suggest that HLA-DRB1 polymorphisms are related to the occurrence and disease progression of pIgAN patients in Han Chinese, with HLA-DRB1*140501 being a susceptible allele and HLA-DRB1*070101 a resistant allele. HLA-DRB1*030101 may serve as a predictor of disease progression and renal damage of pIgAN in Han Chinese. Further studies are warranted to explore the immunological mechanisms for the genotype-disease phenotype relationship.

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“…Clearly the ubiquitous nature of organic solvents makes it improb able that they are capable of causing glomerulonephritis in the absence of predisposing factors. Certain reports suggest a hereditary component in the development of glomerulonephritis with solvent exposure [17,27], while other forms of glomerulonephritis, namely Goodpas ture's disease [28], membranous nephropathy [29], and mesangial IgA disease [30] are well know to have HLA antigen associations.…”

Section: Discussionmentioning

confidence: 99%

Proliferative Glomerulonephritis and Exposure to Organic Solvents

Bell

Gordon

Lee

et al. 1985

Nephron

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Exposure to organic solvents was compared by interview and questionnaire in 50 patients with biopsy-proven proliferative glomerulonephritis in whom there was no evidence of systemic disease or preceding infection with that of 100 control subjects matched for age, sex and social class. The interview was conducted by a lay person who did not know whether the interviewee was a patient with glomerulonephritis or a control subject. The exposure scores derived from the results of the questionnaires were significantly greater in the patients with glomerulonephritis than the control subjects (13,186 ± 3,716 vs. 3,030 ± 1,152, p < 0.01). The degree of exposure was higher in those patients with the more severe diffuse endocapillary proliferative glomerulonephritis than in those with mesangial proliferative glomerulonephritis. In the glomerulonephritis patients solvent exposure was mainly occupational in origin and involved fuels, paints and degreasing agents in most cases. This occupational exposure was significantly greater than in the control subjects (13,061 ± 3,858 vs. 2,878 ± 1,146, p < 0.01). It is suggested that exposure to organic solvents may participate in the pathogenesis of non-systemic proliferative glomerulonephritis.

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Strong association between IgA nephropathy and HLA-DR4 antigen

Cited by 75 publications

References 16 publications

Single-nucleotide polymorphisms in the class II region of the major histocompatibility complex in Japanese patients with immunoglobulin A nephropathy

Single-nucleotide polymorphisms in the class II region of the major histocompatibility complex in Japanese patients with immunoglobulin A nephropathy

Human Leukocyte Antigen <i>DRB1</i> Alleles Predict Risk and Disease Progression of Immunoglobulin A Nephropathy in Han Chinese

Proliferative Glomerulonephritis and Exposure to Organic Solvents

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