Strong association between serological status and probability of progression to clinical visceral leishmaniasis in prospective cohort studies in India and Nepal

Hasker, Epco; Chourasia, Ankita; Malviya, Prashant; Gidwani, Kamlesh; Picado, Albert; Ostyn, Bart; Kansal, Sangeeta; Singh, Rudra Pratap; Singh, O. P.; Singh, Abhishek Kumar; Wilson, Marjorie; Khanal, Basudha; Rijal, Suman; Boelaert, Marleen

doi:10.1016/j.ijid.2014.03.940

Cited by 9 publications

(15 citation statements)

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“…There are literatures which suggested for protective role, whereas others advocated for the pathogenic role of antibodies during Leishmania infection, 2,3,22,23 as they were considered irrelevant for VL unless recent literature suggested for strong correlation of serological status with the disease progression. 24 Similarly, studies of Leishmania major 3 and Leishmania amazonensis 25 suggest for the pathological role of antibodies in the murine system. Considering hypergammaglobulinemia as one of the major immune dysfunctions in VL along with emergence of TLM B-cells during disease led us to explore the role of these hypo-responsive B-cells as determinant for the humoral responses.…”

Section: Resultsmentioning

confidence: 99%

Abnormal B-Cell Subset and Blimp-1–Mediated Humoral Responses Associated With Visceral Leishmaniasis Pathogenesis

Singh

et al. 2019

The American Journal of Tropical Medicine and Hygiene

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B-cells have a spectrum of functions ranging from antibody production to antigen presentation and have additional vital roles in immune mechanisms. There is rudimentary knowledge about the role of B-cells in intracellular infections with contradictory findings. We explored the role of B-cell dysfunctions in visceral leishmaniasis (VL) pathogenesis in terms of the phenotypic and functional properties of B-cells during the course of disease. This study was performed on blood and splenic aspirates (SA) of VL cases pre-and post-treatment. Whole blood was used for flow cytometric studies for determining the profiles of B-cells at different time-points of treatment. Peripheral blood mononuclear cells were used for magnetic purification of B-cells, for transcriptional studies by real-time polymerase chain reaction (RT-PCR). Serum/plasma was used for direct agglutination test for determining parasite-specific antibodies and SA were used for scoring the presence of parasite by microscopic examination. Flow cytometric studies depicted decreased B-cell percentages during the entire course of disease and attainment of exhaustive phenotype with tissue-like memory cell markers, indicative of B-cell dysfunctions in VL. In addition, B-cells had compromised abilities of antigen processing and presentation and altered levels of B-lymphocyte-induced maturation protein-1 (Blimp-1). Blimp-1 expression goes hand in hand with B-cell maturation antigen and transmembrane activator and calcium modulator (TACI) and cyclophilin ligand interactor, suggestive of its role in promoting plasma cell survival and antibody production. Elevated level of VL-specific antibody titre was directly correlated with exhausted phenotype and also with disease severity during VL. This study indicated for impaired B-cell functions during chronic infection which may lead to pathological consequences in human VL.

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Section: Resultsmentioning

confidence: 99%

Abnormal B-Cell Subset and Blimp-1–Mediated Humoral Responses Associated With Visceral Leishmaniasis Pathogenesis

Singh

et al. 2019

The American Journal of Tropical Medicine and Hygiene

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“…Studies of the risk of progression from infection to disease have yielded contradictory results based on serological status; however, the data revealed strong associations between the magnitude of positive serology and risk of progressing to symptomatic VL .…”

Section: Discussionmentioning

confidence: 98%

Seroprevalence of Leishmania infection among asymptomatic renal transplant recipients from southern Spain

Elmahallawy

Cuadros-Moronta

Liébana-Martos

et al. 2015

Transplant Infectious Dis

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“…In human infections, a high titer of Leishmania-specific antibodies are observed in patients with a more severe clinical form of the cutaneous disease, diffuse cutaneous leishmaniasis [122,123], and in patients with VL [117,124], whereas patients with self-healing localized cutaneous leishmaniasis lack Leishmania-specific antibodies or elicit a very weak response [116]. On the other hand, B cells appear to play a protective role in disease pathogenesis, as observed in high prevalence of seropositive healthy individuals in areas endemic for VL [116,125] and longer persistence of antibodies against Leishmania (≥15 years) after the infection has been cured [116,126,127].…”

Section: Discussionmentioning

confidence: 99%

What do we know about the role of regulatory B cells (Breg) during the course of infection of two major parasitic diseases, malaria and leishmaniasis?

Soares

Antinarelli

Abramo

et al. 2017

Pathogens and Global Health

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Parasitic diseases, such as malaria and leishmaniasis, are relevant public health problems worldwide. For both diseases, the alarming number of clinical cases and deaths reported annually has justified the incentives directed to better understanding of host's factors associated with susceptibility to infection or protection. In this context, over recent years, some studies have given special attention to B lymphocytes with a regulator phenotype, known as Breg cells. Essentially important in the maintenance of immunological tolerance, especially in autoimmune disease models such as rheumatoid arthritis and experimentally induced autoimmune encephalomyelitis, the function of these lymphocytes has so far been poorly explored during the course of diseases caused by parasites. As the activation of Breg cells has been proposed as a possible therapeutic or vaccine strategy against several diseases, here we reviewed studies focused on understanding the relation of parasite and Breg cells in malaria and leishmaniasis, and the possible implications of these strategies in the course of both infections.

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Strong association between serological status and probability of progression to clinical visceral leishmaniasis in prospective cohort studies in India and Nepal

Cited by 9 publications

References 0 publications

Abnormal B-Cell Subset and Blimp-1–Mediated Humoral Responses Associated With Visceral Leishmaniasis Pathogenesis

Abnormal B-Cell Subset and Blimp-1–Mediated Humoral Responses Associated With Visceral Leishmaniasis Pathogenesis

Seroprevalence of Leishmania infection among asymptomatic renal transplant recipients from southern Spain

What do we know about the role of regulatory B cells (Breg) during the course of infection of two major parasitic diseases, malaria and leishmaniasis?

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