Strong Coexpression of Transcription Factors PU.1 and Oct-2 in Rosai-Dorfman Disease

Kiruthiga, Kala Gnanasekaran; Younes, Sheren; Natkunam, Yasodha

doi:10.1093/ajcp/aqac119

Cited by 8 publications

(4 citation statements)

References 23 publications

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“…10 It was reported in 2009 as being positive in Langerhans-cell histiocytosis, reticulohistiocytomas, and xanthogranulomas and more recently, in RDD. 11,12 These authors confirmed the specificity of this marker for histiocytosis by showing its negativity on cutaneous lesions such as dermatofibroma, melanoma, Spitz nevi, and fibrous papules. Our study extended the testing on a larger variety of histiocytoses and we confirmed the positivity of PU.1 in all of them.…”

Section: Discussionmentioning

confidence: 71%

“…It is required for the development of Yolk sac‐derived macrophages 10 . It was reported in 2009 as being positive in Langerhans‐cell histiocytosis, reticulohistiocytomas, and xanthogranulomas and more recently, in RDD 11,12 . These authors confirmed the specificity of this marker for histiocytosis by showing its negativity on cutaneous lesions such as dermatofibroma, melanoma, Spitz nevi, and fibrous papules.…”

Section: Discussionmentioning

confidence: 77%

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PU.1 is a useful nuclear marker to distinguish between histiocytosis and histiocyte‐rich tumours

et al. 2023

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Aims The aim was to test the expression of PU.1 on different types of histiocytoses and to test the utility of PU.1 in confirming or excluding a histiocytic origin in tumour samples with suspicion of histiocytosis. Methods and Results We analysed 66 biopsies of nonmalignant histiocytoses represented by Langerhans‐cell histiocytosis (n = 13), Erdheim–Chester disease (ECD) (n = 19), Rosai–Dorfman disease (RDD) (n = 14), mixed ECD‐RDD (n = 3), ALK‐positive histiocytosis (n = 6), and juvenile xanthogranuloma (n = 11). All cases were positive for PU.1 in reactive and neoplastic histiocytes. In addition, 39 cases of tumours with high‐grade cytological atypia were referred to our center as suspicion of malignant histiocytosis/histiocytic sarcoma and only 18 were confirmed. Indeed, more than half of these tumours (21/39) were either undifferentiated malignant tumours with a stroma rich in histiocytes, diffuse large B‐cell lymphoma, or high‐grade dedifferentiated liposarcoma. PU.1 was useful to distinguish between the negativity of large atypical nuclei and the positivity of stromal reactive histiocytes. Conclusion PU.1 is expressed by all types of histiocytosis. It distinguishes histiocytosis from histiocyte‐rich tumours with an easy interpretation due to its sharp nuclear staining. Its negativity in lesional/tumour cells in histiocyte‐like lesions is useful to eliminate a histiocytosis.

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Section: Discussionmentioning

confidence: 71%

Section: Discussionmentioning

confidence: 77%

PU.1 is a useful nuclear marker to distinguish between histiocytosis and histiocyte‐rich tumours

et al. 2023

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“…RDD diagnosis relies on histopathological examination, characterized by distinctive histiocyte proliferation (positive for S100 protein, oct-2, and cyclin D1) exhibiting emperipolesis (phagocytosed lymphocytes within histiocytes) [ 8 ]. While RDD is often perceived as a tumour and surgically resected, the prognosis is favourable for most patients, with spontaneous resolution observed in 20% of cases [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

Rosai–Dorfman disease differentiated from a posterior mediastinal tumour: a case report

Hirai,

Takahashi,

Kaki

et al. 2024

Journal of Surgical Case Reports

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Rosai–Dorfman disease presenting solely with intrathoracic lesions is exceptionally rare. Herein, we report the case of a 53-year-old man presenting with a posterior mediastinal tumour. Computed tomography revealed a 7-cm soft tissue shadow in the posterior mediastinum. Positron emission tomography-computed tomography demonstrated a high maximum standardized uptake value of 10.35 in the tumour, with no evidence of lymph node or other organ involvement. Serum marker levels were within the normal range. Thoracoscopic surgery was performed to obtain a biopsy for a definitive diagnosis and treatment planning. Postoperative histological findings revealed a diffuse infiltration of eosinophilic histiocytes, lymphocytes, and plasma cells. Immunohistochemical analysis indicated positivity for S-100 protein, oct-2, and cyclin D1 in these histiocytes. Consequently, the patient was diagnosed with Rosai–Dorfman disease and is currently asymptomatic, undergoing regular monitoring without treatment as an outpatient. The absence of characteristic findings, such as bilateral cervical lymphadenopathy, posed challenges in preoperative diagnosis.

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“… 12 PU.1 has been suggested as a marker for macrophage differentiation in Rosai–Dorfman disease and Erdheim–Chester disease. 13 , 14 PU.1 may be an additional marker for MS showing monocytic and monoblastic differentiation.…”

Section: Discussionmentioning

confidence: 99%

Myeloid sarcoma incidentally found in lymph nodes dissected for advanced gastric cancer

Yamada

Miyata‐Takata

Tanaka³

et al. 2023

J Clin Exp Hematopathol

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A 93-year-old man was referred to our hospital for the treatment of gastric cancer. He did not have any past medical history. Computed tomography suggested lymph node metastasis around the stomach, but no distant metastases were identified. Laparoscopy-assisted distal gastrectomy with D1 lymphadenectomy was performed. The pathologic stage of gastric cancer was determined as pT3, pN1, cM0, stage IIB (Union for International Cancer Control / American Joint Committee on Cancer 8 th ed.).Microscopic examination revealed poorly differentiated adenocarcinoma in the stomach with two lymph node metastases. A notable finding in the present case was that other than metastatic foci of adenocarcinoma, some lymph nodes showed destructive architecture and proliferation of hematopoietic cells with small-to medium-sized, round or cleaved nuclei, inconspicuous nucleoli, and scant eosinophilic cytoplasm. These cells were distributed mainly in the lymph node sinus and paracortex with perinodal fat infiltration (Figure 1A, B). Scattered hemophagocytosis by mature macrophages was found. Cytochemical staining for naphthol AS-D chloroacetate esterase (NASDCAE) yielded focally positive results (Figure 2A). Immunohistochemically, positive results were obtained for CD4, CD33, CD68 (KP1), Iba-1, lysozyme, myeloperoxidase, and PU.1 (Figure 2B-G), with focally positive results for CD11c, CD13, CD14, CD45, CD68 (PGM1), CD163, and CD204 (Figure 2H, I), and negative results for AE1/AE3,

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Strong Coexpression of Transcription Factors PU.1 and Oct-2 in Rosai-Dorfman Disease

Cited by 8 publications

References 23 publications

PU.1 is a useful nuclear marker to distinguish between histiocytosis and histiocyte‐rich tumours

PU.1 is a useful nuclear marker to distinguish between histiocytosis and histiocyte‐rich tumours

Rosai–Dorfman disease differentiated from a posterior mediastinal tumour: a case report

Myeloid sarcoma incidentally found in lymph nodes dissected for advanced gastric cancer

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