Strong Coupling of Nonlinear Electronic and Biological Oscillators: Reaching the “Amplitude Death” Regime

Ozden, Ilker; Venkataramani, Sowmya; Long, Michael A.; Connors, Barry W.; Nurmikko, A. V.

doi:10.1103/physrevlett.93.158102

Cited by 50 publications

(35 citation statements)

References 14 publications

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“…The firing patterns and degree of synchrony of coupled cells depend on the coupling conductance, as demonstrated by modeling studies of the crustacean stomatogastric ganglion (Sharp et al, 1992) and the mammalian inferior olive (Ozden et al, 2004). These studies show that neurones may fire independently in a weakly coupled system.…”

Section: Role Of Electrotonic Coupling In Rhythm Generationmentioning

confidence: 87%

“…in or out of phase depending on coupling parameters and intrinsic properties of the neurones). Interestingly, at high coupling conductances oscillations completely cease (Ozden et al, 2004). In addition to synchronous firing, electrotonic coupling can also promote and/or stabilise bursting activity (Getting and Willows, 1974;Skinner et al, 1999) and regulate the interburst interval (Sharp et al, 1992).…”

Section: Role Of Electrotonic Coupling In Rhythm Generationmentioning

confidence: 99%

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Strategies for delineating spinal locomotor rhythm-generating networks and the possible role of Hb9 interneurones in rhythmogenesis

Brownstone

Wilson

2008

Brain Research Reviews

137

122

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Despite significant advances in our understanding of pattern generation in invertebrates and lower vertebrates, there have been barriers to the application of the principles learned to the definition of networks underlying mammalian locomotion. Major difficulties have arisen in identifying spinal interneurones in preparations which allow study of neuronal intrinsic properties and the role of identified interneurones in locomotor networks. Recent genetic technologies in which selective expression of fluorescent proteins in specific populations of mouse spinal neurones have provided new avenues of investigation. In this review, we focus on the generation of locomotor rhythm and outline criteria that rhythm-generating neurones might be expected to fulfill. We then examine the extent to which a recently identified population of spinal interneurones, Hb9 interneurones, fulfill these criteria. Finally, we suggest that Hb9 interneurones could be involved in an asymmetric model of locomotor rhythmogenesis through projections of electrotonically coupled rhythmgenerating modules to flexor pattern formation half-centres. The principles learned from studying this population of interneurones have led to strategies to systematically evaluate neurones that may be involved in locomotor rhythmogenesis.

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Section: Role Of Electrotonic Coupling In Rhythm Generationmentioning

confidence: 87%

Section: Role Of Electrotonic Coupling In Rhythm Generationmentioning

confidence: 99%

Strategies for delineating spinal locomotor rhythm-generating networks and the possible role of Hb9 interneurones in rhythmogenesis

Brownstone

Wilson

2008

Brain Research Reviews

137

122

View full text Add to dashboard Cite

show abstract

“…Apart from the Landau-Stuart system, the van der Pol oscillator and other standard nonlinear or chaotic oscillators that are easily realized in analog circuits, a number of hybrid models can also be studied in experiment. This extends the study of mismatched oscillators beyond the cases of dynamic coupling [37] or when the frequencies of coupled units differ [124,125] to the situation when the coupled systems are completely distinct from each other: the interaction between an electronic and biological oscillator-a neural-electronic hybrid interface-can also suppress oscillatory dynamics [126] .…”

Section: Experiments and Applicationsmentioning

confidence: 99%

Amplitude death: The emergence of stationarity in coupled nonlinear systems

2012

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When nonlinear dynamical systems are coupled, depending on the intrinsic dynamics and the manner in which the coupling is organized, a host of novel phenomena can arise. In this context, an important emergent phenomenon is the complete suppression of oscillations, formally termed amplitude death (AD). Oscillations of the entire system cease as a consequence of the interaction, leading to stationary behavior. The fixed points that the coupling stabilizes can be the otherwise unstable fixed points of the uncoupled system or can correspond to novel stationary points. Such behaviour is of relevance in areas ranging from laser physics to the dynamics of biological systems. In this review we discuss the characteristics of the different coupling strategies and scenarios that lead to AD in a variety of different situations, and draw attention to several open issues and challenging problems for further study.

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“…One way to dampen or extinguish such abnormal bursting is to adjust the coupling strengths between a culture and hardware. This technique of purposely inducing the "amplitude death" regime of coupled oscillators has been implemented in tissue-computer systems [108]. One might also prevent interictal-spike-like phenomenon by washing cultures with neurotransmitters that would have come from subcortical efferents to block potassium conductances; however, a more elegant and better studied approach is to use co-cultures.…”

Section: Ectopic Neural Modulesmentioning

confidence: 99%

Techniques and devices to restore cognition

Serruya

Kahana

2008

Behavioural Brain Research

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Executive planning, the ability to direct and sustain attention, language and several types of memory may be compromised by conditions such as stroke, traumatic brain injury, cancer, autism, cerebral palsy and Alzheimer's disease. No medical devices are currently available to help restore these cognitive functions. Recent findings about the neurophysiology of these conditions in humans coupled with progress in engineering devices to treat refractory neurological conditions imply that the time has arrived to consider the design and evaluation of a new class of devices. Like their neuromotor counterparts, neurocognitive prostheses might sense or modulate neural function in a non-invasive manner or by means of implanted electrodes. In order to paint a vision for future device development, it is essential to first review what can be achieved using behavioral and external modulatory techniques. While non-invasive approaches might strengthen a patient's remaining intact cognitive abilities, neurocognitive prosthetics comprised of direct brain-computer interfaces could in theory physically reconstitute and augment the substrate of cognition itself.

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Strong Coupling of Nonlinear Electronic and Biological Oscillators: Reaching the “Amplitude Death” Regime

Cited by 50 publications

References 14 publications

Strategies for delineating spinal locomotor rhythm-generating networks and the possible role of Hb9 interneurones in rhythmogenesis

Strategies for delineating spinal locomotor rhythm-generating networks and the possible role of Hb9 interneurones in rhythmogenesis

Amplitude death: The emergence of stationarity in coupled nonlinear systems

Techniques and devices to restore cognition

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