Mixing of the low-lying three-and five-quark Ω states with spin-parity quantum numbers 1 2 − and 3 2 − is investigated, employing an instanton-induced quark-antiquark pair creation model, which precludes transitions between s 3 and s 4s configurations. Models with hyperfine interactions between quarks of three different kinds, namely, one-gluon-exchange, Goldstone-boson-exchange (GBE) and an instanton-induced interaction (INS) are called OGE, GBE and INS models, respectively. Numerical results show that the instanton-induced pair creation causes strong mixing between the threeand five-quark configurations with spin 3/2, and that this mixing decreases the energy of the lowest spin 3/2 states in all three different hyperfine interaction models to ∼ 1750 ± 50 MeV. On the other hand, transition couplings between s 3 and s 3 qq states with spin 1/2 caused by instanton-induced qq creation is very small and the resulting mixing of three-and five-quark configurations in the OGE and INS models is negligible, while the mixing of the spin 1/2 states in GBE model is not, but effects of this mixing on energies of mixed states are also very small. Accordingly, the lowest Ω states with negative parity in all three hyperfine interactions models have spin 3/2.